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Traditional Chinese medicine composition for treating depression and preparation method thereof

A composition and technology for depression, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of large side effects, easy rebound, long-term use, etc.

Active Publication Date: 2011-11-09
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, drug therapy is the most commonly used drug. The most commonly used depression drugs in clinical practice are mostly western medicines, which usually start to take effect after two weeks of medication. They have relatively large side effects and need to be taken for a long time, and they are easy to rebound after stopping the drug.

Method used

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  • Traditional Chinese medicine composition for treating depression and preparation method thereof
  • Traditional Chinese medicine composition for treating depression and preparation method thereof
  • Traditional Chinese medicine composition for treating depression and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, preparation antidepressant composition decoction one

[0034] Take 3 parts by mass of ginseng, 2 parts by mass of polygala, 2 parts by mass of Shichangpu, 3 parts by mass of Poria cocos, 3 parts by mass of Morinda officinalis, 2 parts by mass of Bupleuri, 2 parts by mass of Citrus aurantium, 3 parts by mass of red peony root, 2 mass parts Combine the licorice, soak in 10 times the amount of water for 1 hour, decoct once, decoct the dregs with 8 times the amount of water again, and decoct the dregs after the second decoction with 6 times the amount of water. 1 hour / time, combine three decoctions, filter, and concentrate the filtrate under reduced pressure to the equivalent of 3g of crude drug per milliliter of medicinal liquid, which is Decoction 1 of Kaixin Jieyu Decoction.

Embodiment 2

[0035] Embodiment 2, preparation antidepressant composition decoction two

[0036] Get 3 parts by mass of ginseng, after crushing, use 10 times the mass of 70% ethanol aqueous solution to reflux extract 3 times, the time of 3 times of extraction is respectively 1 hour, 40 minutes, 40 minutes, after each extraction is completed, filter, collect the filtrate, Merge the filtrate three times, reclaim ethanol, concentrate the filtrate under reduced pressure to the alcohol extraction extract containing 0.5g of crude drug per milliliter of medicinal liquid; Parts of Poria cocos, 3 parts by mass of Morinda officinalis, 2 parts by mass of Bupleurum bupleurum, 2 parts by mass of Citrus aurantii, 3 parts by mass of red peony root, and 2 parts by mass of licorice are combined, decocted 3 times with 10 times the mass of water, 1h / time, combined Decoction, filtration, when the filtrate is concentrated under reduced pressure to half its volume, the concentrated solution is combined with gins...

Embodiment 3

[0037] Embodiment 3, preparation antidepressant composition powder

[0038]Take 3 parts by mass of ginseng, 2 parts by mass of polygala, 2 parts by mass of Shichangpu, 3 parts by mass of Poria cocos, 3 parts by mass of Morinda officinalis, 2 parts by mass of Bupleuri, 2 parts by mass of Citrus aurantium, 3 parts by mass of red peony root, 2 mass parts Glycyrrhizae was dried in an oven at 50°C for 6 hours, each herb was first crushed into coarse powder, then crushed into fine powder, and finally passed through a No. 6 sieve (the powder yield was greater than 80%) to obtain the antidepressant composition powder.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating depression. The traditional Chinese medicine composition is prepared by the following raw materials by mass: 1-6 parts of ginseng, 1-5 parts of polygala, 1-5 parts of grass leaved sweetflag, 1-6 parts of poria cocos, 1-6 parts of morinda officinalis, 1-5 parts of radix bupleuri, 1-5 parts of citrus aurantium, 1-6 parts of red paeonia and 1-5 parts of liquorice. The traditional Chinese medicine composition of the invention has the efficacy of invigorating qi, nourishing heart, soothing nerves, regulating qi and coursing liver, promoting blood circulation and relieving depression; and the combination of the medicine has the efficacy of invigorating qi and relieving depression. It is proved by pharmacodynamic tests that the traditional Chinese medicine composition can significantly improve the behavior abnormality of depression model rats with various types, has the efficacy of treating both the symptoms and root causes, and can effectively treat depression.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a traditional Chinese medicine composition for treating depression. Background technique [0002] Depression, the main type of affective disorder, is a syndrome characterized by significant and persistent low mood. Depression is a common and frequently-occurring disease that endangers the physical and mental health of human beings. It is the main mental problem in the world at present. Its main clinical manifestation is low mood, which leads to the reduction of other activities in life, such as social passivity, decreased aggressiveness, and life. Evacuation, etc. Depression seriously affects people's quality of life and reduces work efficiency. The resulting various intangible losses are costly, and some extremely severe cases may even have passive suicide behaviors. [0003] Therapeutic methods of modern depression mainly contain psychotherapy, drug therapy and electroconvulsive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/24
Inventor 黄世敬王彦云崔翰明潘菊华吴巍
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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