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Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris

The technology of a composition and medicine is applied in the treatment of coronary heart disease, the pharmaceutical composition and its preparation, and the application fields of angina pectoris, which can solve the problems such as the inability to comprehensively combat the symptoms of coronary heart disease, and achieve the enhancement of hypoxia tolerance, simple preparation process, and toxicity. small effect

Inactive Publication Date: 2011-11-02
YUNNAN YUNYAO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs are limited to single indications such as strengthening the body and calming the heart, aromatherapy and warming, or promoting blood circulation and removing blood stasis, and cannot comprehensively fight against all symptoms of coronary heart disease

Method used

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  • Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris
  • Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris
  • Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0026] The original drug of the pharmaceutical composition also includes (parts by weight) 8-14 parts of holly.

[0027] The original drug of the pharmaceutical composition also includes (parts by weight) 8-14 parts of hollywort and 8-14 parts of mistletoe.

[0028] The original drug of the pharmaceutical composition also includes (parts by weight) 8-14 parts of hollywort, 8-14 parts of mistletoe and 8-14 parts of chuanxiong.

[0029] The original drug of the pharmaceutical composition also includes (parts by weight) 8-14 parts of hollywort, 8-14 parts of mistletoe, 8-14 parts of Rhizoma Chuanxiong and 8-14 parts of Corydalis Corydalis.

[0030] The preparation method of any one of the above-mentioned pharmaceutical compositions, comprising the following steps:

[0031] A, the original drug is purified and pulverized respectively;

[0032]B. Weigh the processed traditional Chinese medicine according to the proportion of the formula, mix well, add 2 to 5 times the amount (wei...

Embodiment 1

[0039] The original drug (parts by weight) 15 parts of kudzu root, 21 parts of pangolinia, and 21 parts of ginkgo biloba were pretreated respectively and crushed into coarse powder, the powder was mixed according to the formula ratio, and 3 times the amount (weight ratio) of 50% ethanol was added, Reflux extraction twice, each time for 2 hours, the two extracts were filtered and combined, the alcohol extract was concentrated under reduced pressure at 55°C to a relative density of 1.15-1.17, cooled and dried to obtain a dry powder pharmaceutical composition.

Embodiment 2

[0041] The original drug (parts by weight) 21 parts of kudzu root, 15 parts of pangolinia, and 15 parts of ginkgo biloba were pretreated and pulverized into coarse powder, the powder was mixed according to the formula ratio, and 4 times the amount (weight ratio) of 70% ethanol was added. Reflux extraction twice, each time for 2 hours, the two extracts were filtered and combined, the alcohol extract was concentrated under reduced pressure at 65°C to a relative density of 1.15-1.17, cooled and dried to obtain a dry powder pharmaceutical composition.

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Abstract

The invention discloses a pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris. The pharmaceutical composition comprises the following raw medicines in parts by weight: 15-21 parts of kudzu root, 15-21 parts of yam and 15-21 parts of ginkgo leaf. The pharmaceutical composition is prepared by the following steps of: pretreating the raw medicines, crushing, extracting by reflux with 50-70% ethanol, filtering, combining the ethanol extraction solutions, concentrating at 55-65 DEG C until the relative density is 1.15-1.17, cooling and drying to obtain the pharmaceutical composition in a dry powder state. The pharmaceutical composition and pharmaceutically acceptable auxiliary materials can be prepared into granules, capsules, pills, dripping pills, powder, soluble granules and tablets. The pharmaceutical composition preparation in any dosage form is applied to treatment of coronary heart disease and angina pectoris. The pharmaceutical composition disclosed by the invention has reasonable compatibility and high utilization rate of active ingredients, has an obvious effect on acute myocardial ischemia, has an obvious inhibiting effect on thrombosis of the arteriovenous shut, enhances the hypoxia tolerance ability of a body, promotes the restoration of cardiac functions, is safe, and has low toxicity. Proven by clinical tests, the pharmaceutical composition has obvious therapeutic effects on coronary heart disease and angina pectoris.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations and preparation thereof, and in particular relates to a pharmaceutical composition and its preparation and its application in treating coronary heart disease and angina pectoris. Background technique [0002] Coronary heart disease, angina pectoris, and myocardial insufficiency are common clinical symptoms of middle-aged and elderly people. They are heart diseases caused by coronary artery sclerosis and stenosis resulting in poor blood circulation and insufficient cardiac blood supply, which in turn lead to myocardial ischemia and hypoxia. With the continuous improvement of people's living conditions and the development of health services, the average life expectancy of people has increased significantly. However, the analysis from the three aspects of prevalence rate, morbidity rate and inpatient disease composition shows that the number of cardiovascular disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P9/10
Inventor 王永炎许雷张国华张文生
Owner YUNNAN YUNYAO TECH
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