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Calf spleen extract for treating tumors

An extract, calf technology, applied in antitumor drugs, drug combinations, drug delivery and other directions, can solve the problems of immune function damage, tissue cell destruction, injury and so on

Active Publication Date: 2012-11-28
吉林敖东洮南药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment is mainly based on surgery, radiotherapy, and chemotherapy, but chemotherapy or radiotherapy often causes nausea, loss of appetite, changes in blood images, and damage to the immune function of the body and other toxic and side effects. Tissue cells are also greatly destroyed and damaged accordingly, so many patients cannot persist in completing the course of radiotherapy and chemotherapy, and lose the chance of effective treatment

Method used

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  • Calf spleen extract for treating tumors
  • Calf spleen extract for treating tumors
  • Calf spleen extract for treating tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] Get the spleen of dairy cow (within 24 hours after birth), remove connective tissue and fat, wash with 0.9% sodium chloride solution, add 3 times of normal saline to carry out homogenization, generally carry out 3 times, and the colloid mill particle size is 4 μ m; Put the homogenate into the freezer at -20°C for deep freezing. After it is completely frozen, take it out and put it in a water bath below 30°C to thaw. Keep warm for 35 minutes, quickly cool down to 15°C; centrifuge the above solution at a speed of 3500 rpm, temperature below 5°C, centrifuge for 20 minutes, and collect the supernatant; Dalton's membrane ultrafiltration; 0.20μm filter element sterile filtration sub-package to obtain injection, calf spleen extract injection 2.5ml contains 6.25mg polypeptide, 475μg ribose.

Embodiment 2

[0166] Get the spleen of dairy cow (within 24 hours after birth), remove connective tissue and fat, wash with 0.9% sodium chloride solution, add 4 times of normal saline to carry out homogenization, generally carry out 4 times, and the colloidal abrasive particle size is 3 μm; Put the homogenate into the freezer for deep freezing at 30°C. After it is completely frozen, take it out and thaw it in a water bath below 40°C. After it is completely melted, continue to put it into the freezer. Repeat this three times; keep the frozen-thawed liquid at 80°C For 40 minutes, quickly cool down to 20°C; centrifuge the above solution at a speed of 3000 rpm and a temperature below 4°C for 30 minutes, and collect the supernatant; Ultrafiltration with a membrane of Dunton; 0.20μm filter element sterile filtration and repacking to obtain the injection. Calf spleen extract injection 2.5ml contains 9mg polypeptide and 600μg ribose.

Embodiment 3

[0168] Get the spleen of dairy cow (within 24 hours after birth), remove connective tissue and fat, wash with 0.9% sodium chloride solution, add 2 times of normal saline to carry out homogenization, generally carry out 2 times, and the colloid mill particle size is 5 μm; Put the homogenate into the freezer at -15°C for deep freezing. After it is completely frozen, take it out and put it in a water bath below 25°C to thaw. Keep warm for 35 minutes, quickly cool down to 10°C; centrifuge the above solution at a speed of 3000 rpm, temperature below 2°C, and centrifuge for 20 minutes to collect the supernatant; Dalton's membrane ultrafiltration; 0.20μm filter sterile filtration subpackage, that is, the injection. Calf spleen extract injection 2.5ml contains 10.5mg polypeptide and 950μg ribose.

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Abstract

The invention discloses a calf spleen extract for treating tumors, which contains 5 to 15 weight parts of polypeptides and 0.4 to 1 weight part of ribose. The extract can obviously inhibit tumors, resist mouse white blood cell reduction caused by cyclophosphamide chemotherapeutics and invert the inhibition of cyclophosphamide on bone marrow cells, and the extract can treat acute promyelocytic leukemia.

Description

[0001] The present invention is a divisional application, the original application number is 201010257796.0, the original application date is August 19, 2010, and the original application name is a calf spleen extract for treating tumors. technical field [0002] The invention relates to an extract, in particular to a calf spleen extract for treating tumors. technical background [0003] The incidence and mortality of cancer are increasing year by year, which seriously threatens human health and has become one of the main causes of human death. Western medicine treatment is mainly based on surgery, radiotherapy, and chemotherapy. However, chemotherapy or radiotherapy often causes nausea, loss of appetite, changes in blood images, and impairment of immune function. While cancer cells are inhibited or partially killed, the human body is normal. Tissue cells are correspondingly greatly destroyed and damaged, so many patients cannot persist in completing the course of radiothera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/28A61K9/08A61P35/00A61P35/02A61P7/00A61K31/675A61K35/26
Inventor 杨振军董秀华王银叶邹兆鹏王国栋刘巍朱天全孙申国程志国吴丹曾艳
Owner 吉林敖东洮南药业股份有限公司
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