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Oral instant membrane and preparation method thereof

An oral instant film and oral cavity technology, applied in the field of nano-biomedical materials, can solve the problems of low production efficiency, achieve low cost, improve biocompatibility, objective economic and social benefits

Inactive Publication Date: 2011-10-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To overcome the defects of low production efficiency of traditional electrospinning technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The freeze-dried egg white powder was dissolved in purified water and ultrasonicated for 0.5 h to form a homogeneous, transparent and viscous 30% wt egg white liquid. Dissolve polyvinylpyrrolidone with a molecular weight of 1,300,000 in purified water, and magnetically stir for 3 hours to form a homogeneous, transparent, and viscous 10% polyvinylpyrrolidone solution. According to the mass ratio of egg white liquid and polyvinylpyrrolidone solution of 1:3, the gas electrospinning liquid was mixed evenly to obtain the gas electrospinning solution, which was added to the gas electrospinning device. The mass flow rate is 0.1ml / h, the receiving distance is 8cm, the ambient temperature is 25°C, and the ambient humidity is 50% for gas electrospinning. An air electrospinning membrane composed of nanofibers with a diameter of 50-200 nm is obtained. Dry at a constant temperature of 40° C. for 12 hours, cut into 1 cm×1 cm, and finally obtain an oral instant film preparation free ...

Embodiment 2

[0020] The freeze-dried egg white powder was dissolved in purified water and ultrasonicated for 0.5 h to form a homogeneous, transparent and viscous 30% wt egg white liquid. Dissolve polyvinylpyrrolidone with a molecular weight of 1,300,000 in purified water, and magnetically stir for 3 hours to form a homogeneous, transparent, and viscous 10% polyvinylpyrrolidone solution. According to the mass ratio of egg white liquid and polyvinylpyrrolidone solution of 1:1, the gas electrospinning liquid is mixed evenly to obtain the gas electrospinning solution, which is added to the gas electrospinning device. The mass flow rate is 0.5mL / h, the receiving distance is 8cm; the ambient temperature is 25°C; the ambient humidity is 40% and the high-voltage electrospinning is carried out to obtain nanofiber membranes with a diameter of 40-100nm, which are cut according to 1cm×1cm , and finally obtain an oral instant film preparation free of drugs and preservatives.

Embodiment 3

[0022] The freeze-dried egg white powder was dissolved in purified water and ultrasonicated for 0.5 h to form a homogeneous, transparent and viscous 25% wt egg white liquid. Dissolve polyvinylpyrrolidone with a molecular weight of 100,000 in purified water, stir magnetically for 0.5 h, mix evenly according to the mass ratio of egg white liquid and polyvinylpyrrolidone solution at a ratio of 1:2 to obtain an air electrospinning liquid, and add it to the air electrospinning device. Under the conditions of voltage 0KV, gas flow rate 10L / min, syringe pump mass flow rate 0.5mL / h, receiving distance 8cm, ambient temperature 25°C, and ambient humidity 50%, the high-pressure airflow wire is carried out. A submicron-level air-spun membrane with a diameter of 100-500nm was obtained, dried at a constant temperature of 40°C for 12 hours, and cut into 1cm×1cm, and finally an oral instant film preparation free of drugs and preservatives was obtained.

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Abstract

The invention provides an oral instant membrane comprising edible nano fibers and a preparation method thereof, belonging to the fields of nano-biological medical materials and oral instant membranes preparation by utilizing a pneumoelectric spinning technology. The method comprises the following steps: preparing a protein fluid, polyvinylpyrrolidone, medicaments and a preservative according to a proportion to serve as a pneumoelectric spinning solution; uniformly mixing, and spraying from a spray needle; and controlling the gas flow velocity to be between 1 and 10L / min, voltage to be between 10 and 20KV, mass flow velocity of an injection pump to be between 0.1 and 1ml / h, and receiving distance to be between 5 and 15cm. The oral instant membrane can reach nanometer grade by utilizing the pneumoelectric spinning technology, and has the excellent characteristics of nano-biological materials; then, proper medicaments are added on the basis of the oral instant membrane according to different medical requirements, such as nitroglycerin, ibuprofen, loperamide hydrochloride, risperidone and other medicaments, so that a medical membrane made of an edible biological material can be obtained; and finally, the pneumoelectric spinning technology is utilized to improve the production efficiency, and the oral instant membrane is expected to be used in industrial production.

Description

Technical field: [0001] The invention relates to an oral instant film composed of nanofibers and a preparation method thereof, specifically preparing an edible instant oral film by gas electrospinning, belonging to the field of nanobiological medical materials and the technical field of gas electrospinning. Background technique: [0002] 1. At present, the types of commonly used drugs are mostly ordinary tablets, oral liquids, and orally disintegrating tablets. Ordinary tablets are difficult to swallow and are not suitable for children and elderly patients. The oral liquid is inconvenient to carry and is easy to break. The preparation process of orally disintegrating tablets is complicated, and there are disadvantages such as fragility and moisture, which affect the application of many drugs. [0003] 2. After the oral instant tablet is quickly dissolved, some drugs can be transported through the oral cavity, sublingual and tongue mucosa, and absorbed into the blood, avoid...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/42D01F8/02D01F8/10D01F1/10A61K47/32
Inventor 沈晓芳李滟波殷倩庞月红
Owner JIANGNAN UNIV
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