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Method and product

A technology of products and substances, applied in separation methods, chemical instruments and methods, drug combinations, etc.

Inactive Publication Date: 2011-09-28
UNIVERSITY OF BRADFORD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, easily oxidized APIs or guests cannot be processed using this technique

Method used

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Embodiment Construction

[0032] The preferred method of the present invention is a continuous flow process. The ability to implement synthetic methods as a continuous process is a significant advantage over traditional batch methods. Advantages include improved efficiency, simplification of scale-up, consistency of product characteristics, and reduced need for cleaning over batch processes.

[0033] In preferred embodiments, the first substance is an active pharmaceutical ingredient (API). As mentioned above, there is a particular need in the pharmaceutical field for improved methods of making co-crystals. Disadvantages of state-of-the-art techniques include labor intensive, slow, inconsistent and / or unstable, do not adhere to scale-up issues, or a combination of these issues. However, it should be noted that the present invention has applications beyond the field of pharmaceuticals, including, for example, agricultural chemicals, explosives, health foods, pigments, dyes, lubricating oil additives, ...

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Abstract

The present invention provides a method of producing a co-crystal, the method comprising the steps of, providing a first substance and a second substance, wherein the first and second substances are compatible to form a co-crystal, mixing said first and second substances together, and exposing the mixture of said first and second substances to prolonged and sustained conditions of pressure and shear, sufficient to form a co-crystal of said first and second substance.The prolonged and sustained conditions of pressure and shear are preferably applied in an extrusion process. Associated compositions and uses thereof are also provided.

Description

technical field [0001] The present invention relates to methods for the formation of products useful in traditional Chinese medicine, and to products formed by such methods. The present invention relates particularly, but not exclusively, to methods of forming co-crystal products using extrusion, and products obtained or obtainable by such methods. Background technique [0002] Crystal engineering is currently being investigated as a method to tune the physicochemical properties of active agents. By rethinking the types of molecules and intermolecular reactions that can be used to form crystal complexes with the help of pharmaceuticals, the application of crystal engineering to pharmaceuticals opens up the possibility for the development of a wider range of multicomponent structures containing active pharmaceutical ingredients (APIs). new way. Crystal engineering offers promising potential alternatives that can be used to improve drug solubility, dissolution and bioavailab...

Claims

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Application Information

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IPC IPC(8): B01D9/00A61K9/14A61K9/16A61K9/20
CPCA61K31/192B01D9/005A61K31/445A61K45/06A61K31/55A61P1/04A61P17/00A61P21/00A61P25/00A61P25/04A61P29/00A61K2300/00
Inventor 阿南特·帕拉德卡艾德里安·凯利菲尔·科茨彼得·约克
Owner UNIVERSITY OF BRADFORD
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