Preprocessing system for near-infrared online detection and application thereof

A pretreatment, near-infrared technology, used in the preparation of test samples, measurement devices, color/spectral characteristics measurement, etc., can solve the problems of spectral acquisition repeatability, poor stability and reliability, and achieve online quality control, The effect of spectral stability and improved accuracy

Inactive Publication Date: 2011-09-28
ZHEJIANG UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a near-infrared on-line detection preprocessing system to solve the problems of poor repeatability, stability and reliability of spectrum collection generated in the application of near-infrared spectral analysis technology to the pharmaceutical process, and to promote near-infrared on-line detection technology promotion and application of

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  • Preprocessing system for near-infrared online detection and application thereof
  • Preprocessing system for near-infrared online detection and application thereof
  • Preprocessing system for near-infrared online detection and application thereof

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Experimental program
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Embodiment 1

[0027] see figure 1 , the present invention provides a near-infrared on-line detection pretreatment system, which consists of a filter 1, a spare filter 2, a frequency conversion centrifugal pump 3, a temperature control device 4, a buffer device 5, a flow meter 6, a near-infrared spectrum acquisition device 7, an automatic Sampling device 8, liquid inlet 9, and liquid outlet 10. Filter 1 discharges liquid through the filter pneumatic switch valve 15. Backup filter 2 discharges liquid through the backup filter. The through valve 24 is connected to the main pipeline of the temperature control device 4, and the frequency conversion centrifugal pump 3 is connected to the pneumatic switch valve 26 of the liquid inlet. After that, the liquid is divided into two paths, one of which is connected to the pneumatic switch valve 27 of the liquid outlet, and the pneumatic switch valve 27 of the liquid outlet is connected. The switch valve 27 is connected with the liquid outlet 10, and the...

Embodiment 2

[0034]see Figure 1~2 , Extraction process of Radix Paeoniae Rubra: Add 250 kg of Radix Paeoniae Rubra, add 10 times the amount of purified water to soak for 1 hour, extract at 100 °C for 2 hours, and install an external circulation between the bottom and the top of the 3-ton extraction tank (production equipment) The pipeline ensures the continuous circulation of the extraction liquid during the extraction process, so that the medicinal liquid in the extraction tank is evenly distributed and prevents the local concentration from being too high. Connect the liquid inlet 9 and the liquid outlet 10 to the ports 9' and 10' of the external circulation pipeline of the 3-ton extraction tank respectively (see figure 2 ), the cleaning fluid pneumatic switch valve 11 is connected to purified water.

[0035] Start the automatic control system. After the soaking process is over, turn on the frequency conversion centrifugal pump 3, the pneumatic switch valve 26 at the liquid inlet and t...

Embodiment 3

[0049] The mixed extraction process of Chuanxiong, Danshen and Angelica: each 60 kg of Chuanxiong, Danshen and Angelica, add 10 times the amount of purified water to soak for 1 hour, and then extract at 95°C for 2 hours.

[0050] According to the method of embodiment 2, do not use this pretreatment system, directly collect near-infrared spectrum by conventional on-line detection device, analyze the ferulic acid concentration and solid content in the extract sample that collects, establish ferulic acid and solid content The partial least squares model was used to analyze the concentration and solid content of ferulic acid in the extraction process. Similarly, using this pretreatment system, according to the above modeling process, the near-infrared partial least squares model of ferulic acid and solid content was established respectively, and it was applied to the online analysis of ferulic acid in the mixed extraction process of Chuanxiong, Danshen and Angelica. Acid concentra...

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Abstract

The invention provides a preprocessing system for near-infrared online detection, which is composed of a filter, a back-up filter, a variable-frequency centrifugal pump, a temperature control device, a buffering device, a flowmeter, a near-infrared spectrum acquisition device, an automatic sampling device, a liquid inlet and a liquid outlet. The preprocessing system provided by the invention can run automatically, continuously and reliably, and can be switched for use under the condition of not affecting the function of the whole system, therefore, the automatic positive and negative washing can be realized simultaneously, the samples of acquired spectrums can be acquired in a targeted mode, and the cleaning and beauty of the whole system can be maintained. By using the preprocessing system provided by the invention, the problem of difficulty in detection caused by more insoluble solid particles, unstable flow, easily-produced bubbles and large temperature fluctuation in the process of near-infrared online detection is solved, so that the acquired near-infrared spectrum is stable, reliable, and good in repeatability, thereby improving the accuracy of results of near-infrared on-line detection, promoting the development and application of the near-infrared spectral analysis technology in pharmaceutical production processes, and then truly realizing on-line quality control.

Description

technical field [0001] The invention belongs to the technical field of near-infrared on-line detection, and in particular relates to a near-infrared on-line detection preprocessing system and its application. Background technique [0002] Near-infrared spectral analysis technology is a new type of online detection technology, which has the advantages of convenient spectrum acquisition, short analysis time, no damage to samples, no consumption of reagents, and no pollution to the environment. It has been widely used in food, petroleum, chemical and other fields. Near-infrared spectroscopy analysis technology can complete multi-index detection of complex systems through mathematical modeling, so it is very suitable for real-time analysis of traditional Chinese medicine production processes, such as traditional Chinese medicine extraction process, concentration process, alcohol precipitation process, column chromatography process, etc. However, due to the particularity of the p...

Claims

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Application Information

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IPC IPC(8): G01N21/35G01N1/28G01N21/359
Inventor 刘雪松金叶陈勇吴永江余立雁王龙虎
Owner ZHEJIANG UNIV
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