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Preparation method of compound honeysuckle flower and forsythia ammonia-sensitive capsules

A technology of Yinqiao ammonia-sensitive capsules and compound prescriptions, which is applied in capsule delivery, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc. It can solve the volatile loss of oil components and cannot guarantee the long-term stability of volatile oil components Existence, poor drug stability and other problems, to achieve the effect of facilitating the preparation process, improving water solubility, and poor water solubility

Active Publication Date: 2011-09-21
XINJIANG QUANAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this preparation adopts traditional capsule production route to prepare in the production process, promptly after acetaminophen, vitamin C and chlorpheniramine maleate are mixed, other three kinds of volatile oil components (forsythia volatile oil) in the prescription are mixed. , peppermint oil, Nepeta volatile oil) is added by dissolving and spraying into particles with ethanol, so the oil components are easily volatilized and lost during the production process, resulting in poor drug stability and unable to guarantee the long-term stable existence of volatile oil components

Method used

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  • Preparation method of compound honeysuckle flower and forsythia ammonia-sensitive capsules
  • Preparation method of compound honeysuckle flower and forsythia ammonia-sensitive capsules
  • Preparation method of compound honeysuckle flower and forsythia ammonia-sensitive capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Extraction of Forsythia volatile oil and Nepeta volatile oil

[0076] The following operations were used to extract the volatile oil of Forsythia and Schizonepetae respectively:

[0077] Weigh the medicinal materials according to the proportion of the prescription, put them in a volatile oil extractor, add water to the specified amount, slowly heat to boil, keep slightly boiling within the specified time, extract the volatile oil, and store the oil in a sealed seal.

[0078] The extracted volatile oils of Forsythia and Schizonepetae are mixed with peppermint oil to form a mixed volatile oil.

[0079] 1. Determination of density of mixed volatile oil

[0080] Accurately measure 3 parts of 10ml of mixed volatile oil, then accurately measure the weight, and calculate the density of volatile oil at room temperature according to the following formula. The measurement results are shown in Table 1.

[0081]

[0082] Table 1 Determination results of volatile o...

Embodiment 2

[0089] Example 2: Inclusion of volatile oil mixture and β-cyclodextrin

[0090] The 50% ethanol solution of volatile oil in this example is prepared by the following method: accurately absorb the prescription amount of Forsythia volatile oil and Nepeta volatile oil prepared in Example 1 and the prescription amount of peppermint oil to make a volatile oil mixture, and a certain amount of volatile oil Put the mixed solution in a volumetric flask, add an appropriate amount of absolute ethanol, constant volume, and prepare a 50% volatile oil ethanol solution, shake well, seal, and set aside.

[0091] The inclusion of volatile oil mixture and β-cyclodextrin is prepared by the following method: using saturated aqueous solution method, weigh a certain amount of β-CD in an appropriate amount of water, heat to dissolve, cool to the corresponding temperature in a water bath, and make a saturated solution Add a certain amount of 50% volatile oil ethanol solution to the saturated soluti...

Embodiment 3

[0114] Example 3: Inclusion of volatile oil mixture with hydroxypropyl β-cyclodextrin (HP-β-cyclodextrin)

[0115] Adopt the method for embodiment 2 to prepare 50% volatile oil ethanol solution, set aside.

[0116] The inclusion complex of the volatile oil mixture and HP-β-cyclodextrin is prepared by the following method: adopt the aqueous solution method, weigh a certain amount of HP-β-CD in an appropriate amount of water according to the experimental design plan, heat to dissolve, and stir at a certain speed Add a certain amount of 50% ethanol solution of volatile oil, and clathrate at a certain temperature. Evaporate under reduced pressure and place in an oven at 45°C for 4 hours to obtain a solid clathrate. Wherein the ratio of HP-β-CD: volatile oil mixture, stirring speed and clathration temperature were carried out according to the data provided in Table 6 below.

[0117] Using the method of Example 2, the oil utilization of the volatile oil in the clathrate was dete...

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Abstract

The invention belongs to the technical field of pharmacy, and particularly provides a preparation method of novel compound honeysuckle flower and forsythia ammonia-sensitive capsules. The method comprises a step of including mint oil, forsythia volatile oil, fine-leaf schizonepeta herb and cyclodextrin to form an inclusion. By the preparation method provided by the invention, the volatile oil components in the prepared compound honeysuckle flower and forsythia ammonia-sensitive capsules are kept stable for a long term, so accuracy of the formula of the preparation and curative effect of the medicament are ensured. Moreover, the invention also provides the compound honeysuckle flower and forsythia ammonia-sensitive capsules prepared by adopting the method.

Description

technical field [0001] The invention belongs to the technical field of pharmacy. Specifically, the present invention relates to a compound Yinqiao ammonia-sensitive capsule with stable ingredients, safe and effective. Background technique [0002] Compound Yinqiao Aminomin Capsules have been sold and used in the market for many years, with clear curative effects, and no adverse reactions have been reported since it was launched in 2002. The capsule prescription generally consists of acetaminophen, chlorpheniramine maleate, forsythia volatile oil, peppermint oil, vitamin C, Yinqiao extract, nepeta volatile oil and auxiliary materials. Specifically, every 1000 capsules of compound Yinqiao aminomin capsules consist of the following components: 113g of paracetamol, 1.13g of chlorpheniramine maleate, 0.32ml of forsythia volatile oil, 1.16ml of peppermint oil, 53.23g of vitamin C, Yinqiao extract 161.3g, nepeta volatile oil 0.24ml and appropriate amount of auxiliary materials. ...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K36/899A61K9/48A61K47/48A61P11/00A61P29/00A61P31/00A61K31/167A61K31/375A61K31/4402
Inventor 王海峰滕亮温晋雄霍泽君王峄石柳杨文强
Owner XINJIANG QUANAN PHARMA
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