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Pharmaceutical composition for treating bronchial asthma and preparation method of pharmaceutical composition

A technology for bronchial asthma and a composition is applied in the field of traditional Chinese medicine for the treatment of bronchial asthma, and can solve problems such as difficulty in determining the curative effect, unclear mechanisms such as effective ingredients, mode of action, pathways and targets, and different understandings of etiology and pathogenesis.

Inactive Publication Date: 2011-08-10
王晓岩 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as: Although there are many drugs for the treatment of asthma. However, there is no recognized traditional Chinese medicine preparation that can quickly control the acute attack of asthma and significantly prevent asthma recurrence; most drugs are limited to clinical efficacy observations, and animal experiments are less. The mechanism of the disease is not clear; the etiology and pathogenesis have different understandings, so it is difficult to unify the treatment methods and determine the curative effect

Method used

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  • Pharmaceutical composition for treating bronchial asthma and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating bronchial asthma and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating bronchial asthma and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Honey ephedra 380g, fried bitter almond 380g, shegan 350g, asarum 110g.

[0017] 1. Take Shegan, add 6 times the amount of 60% ethanol, soak for 20 minutes, reflux extraction for 2 hours, filter, and use the filtrate for later use, then use 60% ethanol to reflux extract twice, add 5 times the amount of alcohol each time, and reflux extraction After 2 hours, filter, combine the three ethanol extracts, recover ethanol under reduced pressure, and concentrate to 80°C when the measured relative density is 1.20;

[0018] 2. Take another asarum, add 15 times the amount of water, and extract the volatile oil by steam distillation. The obtained volatile oil is clathrated with β-cyclodextrin, and the liquid is filtered and stored separately;

[0019] 3. Take asarum medicinal residues, honey ephedra, and fried bitter almonds, add 1.0 times the amount of water, soak for 1 hour, and decoct twice, each time adding water is 8 times the amount of decocted herbs, decoct for 30 minutes, ...

Embodiment 2

[0021] Honey ephedra 400g, fried bitter almond 400g, shegan 360g, Asarum 120g.

[0022] 1. Take Shegan, add 7 times the amount of 70% ethanol, soak for 30 minutes, reflux extraction for 2 hours, filter, and use the filtrate for later use, then use 70% ethanol to reflux extract twice, add 6 times the amount of alcohol each time, and reflux extraction After 2 hours, filter, combine the three ethanol extracts, recover ethanol under reduced pressure, and concentrate to 80°C when the measured relative density is 1.22;

[0023] 2. Take another asarum, add 20 times the amount of water, extract the volatile oil by steam distillation, the obtained volatile oil is clathrated with β-cyclodextrin, and the liquid is filtered and stored separately;

[0024] 3. Take Asarum medicinal residues, honey ephedra, and fried bitter almonds, add 1.2 times the amount of water, soak for 2 hours, and decoct twice, each time adding water is 9 times the amount of decocted medicinal materials, decoct for 4...

Embodiment 3

[0026] Honey ephedra 420g, fried bitter almond 420g, shegan 370g, Asarum 130g.

[0027] 1. Take Shegan, add 8 times the amount of 80% ethanol, soak for 40 minutes, reflux extraction for 2 hours, filter, and use the filtrate for later use, then use 80% ethanol to reflux extract twice, add 7 times the amount of alcohol each time, and reflux extraction After 2 hours, filter, combine the three ethanol extracts, recover ethanol under reduced pressure, and concentrate to 80°C when the measured relative density is 1.25;

[0028] 2. Take another asarum, add 25 times the amount of water, and extract the volatile oil by steam distillation. The obtained volatile oil is clathrated with β-cyclodextrin, and the liquid is filtered and stored separately;

[0029] 3. Take Asarum medicinal residues, honey ephedra, and fried bitter almonds, add 1.5 times the amount of water, soak for 3 hours, and decoct 3 times, each time adding water is 10 times the amount of decocted medicinal materials, decoc...

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Abstract

The invention relates to a pharmaceutical composition for treating bronchial asthma and a preparation method of the pharmaceutical composition, belonging to the field of the traditional Chinese medicine. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 380-420 parts of Chinese ephedra, 380-420 parts of fried bitter apricot kernel, 350-370 parts of blackberry lily and 110-130 parts of asarum. The composition in the invention is capable of warming lung and dispelling cold, resolving sputum and relieving asthma; and the composition is used for treating the asthma, and the symptoms such as tachypnea, wheezing with sound in throat and choking sensation in chest and the like; and the composition is mainly used for treating the asthma caused by coldness.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating bronchial asthma. Background technique [0002] Bronchial asthma refers to an idiopathic, recurrent, dyspnea disease, and is a chronic airway inflammatory disease with complex immune mechanism mediated by various cellular inflammatory mediators and cytokines. The main manifestations are recurrent wheezing, dyspnea, chest tightness or coughing, etc., which are often induced by inhalation of pollen, dust, cold air or viral infection, exercise and drugs. Bronchial asthma has a high incidence rate, often recurrent attacks, and is extremely difficult to cure. The prevalence rate in the population reported abroad is 5% to 10%, and the domestic prevalence rate accounts for about 1% to 2% of the population. Therefore, the research on the pathogenesis and prevention of bronchial asthma has always been one of the hot spots of medical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P11/06
Inventor 王玉王晓岩王胜圣
Owner 王晓岩
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