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Nutritional composition for infants delivered via caesarean section

A nutritional composition, the technology of the composition, applied in the direction of drug combination, application, food science, etc., can solve the problems of non-optimal response to different, delayed colonization, etc.

Inactive Publication Date: 2011-07-20
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a small cohort of cesarean infants will respond differently due to delayed colonization and suboptimal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1: Molecules of the Gut Microbiota of Vaginally Birthed Infants and Caesarean Section Infants characterize

[0083] In the present study, the effect of mode of delivery (cesarean versus vaginal delivery) on the composition of the gut microbiome at day 3 was investigated by PCR amplification using species-specific primers for Bacteroides and Escherichia coli.

[0084] Microbial DNA was extracted and analyzed according to Favier et al, Environ Microbiol 2002; 68: 219-226; Satokari et al, Appl Environ Microbiol 2001; 67: 504-513; Satorkari et al System Appl Microbiol 2003; 26: 572-584.

[0085] The bacterial species detected in stool samples obtained on day 3 of birth from 23 neonates delivered by cesarean section and from 23 neonates delivered vaginally on day 3 were as follows:

[0086] Escherichia coli was found in 9 of 23 vaginal delivery neonates (39.1%), while only 2 of 23 cesarean delivery neonates were found to have E. coli (8.7%).

[0087] Bacteroides...

Embodiment 2

[0090] Example 2: Composition for caesarean section babies

[0091] An infant formula was prepared comprising 21 g / l protein, 24 g / l fat, 83 g / l carbohydrates, 8 g / l non-digestible oligosaccharides, 5 g / l minerals and 0.45 g / l vitamins.

[0092] Fat was added to UHT sterilized milk at 70°C and the mixture was homogenized in two stages, the first stage at 200kg / cm 2 , the second stage at 50kg / cm 2 . The mixture was prepared at 37°C at 1.5% containing 1 to 5×10 9 Bacteria / ml culture of Bifidobacterium breve 1-2219 was inoculated and incubated at 37°C for 8h. Then, the mixture was cooled to 5 °C. Dissolve the remaining ingredients in water and add to the resulting product. The composition comprises 0.72 g of β-galacto-oligosaccharides and 0.08 g of long-chain and / or short-chain inulin per 100 ml of ready-to-drink formula.

[0093] Add another 250ml of heat killed B. fragilis. The heat-killed Bacteroides fragilis is obtained by culturing Bacteroides fragilis to a cell den...

Embodiment 3

[0095] Example 3: Composition for caesarean section babies

[0096] An infant formula was prepared containing, per 100 g of dry matter: protein (80% casein and 20% whey) 13 g; vegetable fat 25.5 g; lactose 42.25 g; maltodextrin 16 g; minerals 3 g; vitamins 0.25 g .

[0097] Vegetable fat was added to milk heated at 75°C. Homogenize the mixture in two stages, the first stage at 200kg.s / cm 2 , the second stage at 50kg.s / cm 2 . Aqueous solutions of lactose, maltodextrin, vitamins and minerals are added. The composition was pasteurized at 115°C and concentrated by evaporation to 48% dry matter. The concentrate was cooled to 37 ° C, with 5% containing 10 9 Bacteria / ml B. breve 1-2219 culture was inoculated and incubated at 37°C for 8h.

[0098] Add another 250ml of heat killed B. fragilis. The heat-killed Bacteroides fragilis is obtained by culturing Bacteroides fragilis to a cell density of 7×10 in the chemically defined medium of 250 ml Varel & Bryant, 1974, Appl Microb...

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PUM

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Abstract

The present invention relates to compositions to be administered to infants delivered via caesarean section and in particular to a product comprising inactivated cells and / or bacterial cell fragments of Gram-negative bacteria and of optionally inactivated Gram-positive bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.

Description

technical field [0001] The present invention relates to methods of feeding cesarean infants and compositions for administering cesarean infants. Background technique [0002] A baby's gut is generally sterile before birth. During vaginal delivery, the infant's gut is inoculated with the mother's vaginal and / or fecal bacteria, resulting in colonization of the infant's gastrointestinal tract with bacteria from the mother. A healthy gut microbiome from the mother has several positive effects on the baby, such as reducing the incidence of infections and strengthening the immune system. Negele et al, 2004, Pediatr. Allergy Immunol. 15: 48-54 disclose an increased risk of wheezing and allergic sensitization in infants delivered by cesarean section. [0003] In infants delivered by caesarean section, colonization by gut bacteria is delayed and occurs by microbes present in the hospital environment, leading to the formation of a different, suboptimal gut microbiome. The gut micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/12A61P17/00A23C9/123A23C9/13A23L1/30A23L1/308A61K31/702A61K35/74A61P1/12A61P11/06A23L33/00A61K35/744A61K35/745A61K35/747
CPCA61K35/745A23V2002/00A23C9/1234A61K35/747A23L1/3014A23L1/308A23L1/296A61K35/744A23L1/09A23C21/026A23C9/1236A23L29/30A23L33/40A23L33/135A23L33/21A61P1/12A61P11/06A61P17/00A61P31/04A23V2200/3204A23V2200/3202A23V2250/28A23V2200/32
Inventor J·施密特F·里克罗伊斯P·杰瑟尼B·斯塔尔G·贝姆E·佩林
Owner NV NUTRICIA
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