Full-automatic double-ccd photosensitive element digital microscope

Abstract

The invention discloses a full-automatic double-ccd (charge-coupled device) photosensitive element digital microscope, which is used for acquiring specimen image information by synchronously using a colored ccd photosensitive element and a black-and-white ccd photosensitive element so as to obtain a multifocal plane holographic three-dimensional image, synchronously outputting a specimen reading result according to nucleus integral optical density acquired by the black-and-white ccd photosensitive element, and finally outputting a specimen picture and text report. Additionally, the full-automatic double-ccd photosensitive element digital microscope comprises a slide uploading and unloading device and a horizontal migration clamping device for automatically changing the specimen slide, and then, the slide is located in three dimensions through a three-dimensional frame, so that the colored ccd photosensitive element and the black-and-white ccd photosensitive element can conveniently acquire the image information of the specimen. Thus, the full-automatic double-ccd photosensitive element digital microscope can be used for not only performing morphological observation on the specimen, but also taking digital images for a dyed tissue section so as to form the multi-focal plane holographic three-dimensional image, so that all the information of the cell can be observed in multiple layers and multiple focal planes, and accuracy of early diagnosis is greatly improved.

Description

technical field [0001] The invention relates to a microscope, in particular to a digital microscope with dual ccd photosensitive cameras fully automatically controlled, which is mainly used in the technical fields of medical and biological microdiagnosis, and is also suitable for other fields requiring microscopic inspection. Background technique [0002] The development of medicine, especially the development of pathology, mainly relies on the magnification of optical microscopes to provide a hardware basis for doctors and researchers to observe tissue samples in detail. In the field of pathology research as well as in everyday medical practice, there is a growing need for the processing of complex data, the application of record-keeping or archiving systems, and the possibility of interactive consultation of examination results. [0003] In order to improve the speed of pathological research and the accuracy of pathological diagnosis, a microscope with digitized glass slid...

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Problems solved by technology

[0003] In order to improve the speed of pathological research and the accuracy of pathological diagnosis, a microscope with digitized glass slides has appeared, which can automatically supply glass slides, such as the slide supply equipment described in Chinese patent 200480017398.4, which respectively use worm gear mechanisms The vertical height of the slide box loaded with slides is lifted, and the rack and pinion mechanism moves the slide box laterally, so that the slide box can reach a suitable position, which is convenient for the manipulator driven by the lead screw to carry Clamping and supplying of glass slides. It can be seen from this that the equipment firstly uses a slide box to transport the slides collectively, and then uses a manipulator to supply the slides one by one. Therefore, its structure is relatively complicated and the transmission efficiency Low, and at the same time, the complex mechanical structure is prone to accumulative precision errors. When using a manipulator to clamp and supply glass slides, when the screw drives the forearm of the manipulator to move to clamp the glass slides, the clamping force is not suitable for control, which is very easy As a result, when the slide glass is clamped and released, the slide glass is broken, which affects the normal operation of the microscopy work; moreover, when the slide box is moved horizontally and vertically, the mechanism may be out of control, causing the glass slide Pieces broken

Another example is the microscopic automatic searcher disc changer disclosed in Chinese patent 200420018021.8, which is to contain the slides in the slide box, and then use the slide box movement mechanism to drive the slide box to move vertically to the place where the slides are placed. position, and then the slide movement mechanism moves horizontally to drive the end plate to take the slide out of the slide box, and at the same time, the three-dimensional stage quickly moves the slide holder to the corresponding position along the X direction to hold the slide Finally, the slide holder moves reversely with the stage to bring the slide under the microscope for microscopic inspection. It can be seen that the slide changer has the following disadvantages: the drive end plate directly puts the slide It comes out of the slide box, and the slide movement mechanism is used to drive the end plate horizontally. Therefore, the slide is not clamped during transportation, which will easily cause the slide to fall and be damaged, which will affect the normal microscope inspection. In addition, the mechanism is complex and cumbersome, and multiple drive motors are used, which wastes energy, increases the volume of the equipment, and is inconvenient to install

At the same time, since pathological diagnosis is based on the experience of doctors, the so-called gold standard of pathological diagnosis is also based on the premise of individual experience, which is not objective and standardized.

Also working under the microscope for long hours is tiring and inefficient

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