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Method for preparing senkyunolide I from extract of Chinese angelica

A technology of angelica extract and ligusticolactone, which is applied in the field of preparation of lisanthemum lactone I, can solve the problems of cumbersome preparation methods and low yield, and achieve the effect of simplifying the preparation process and increasing the yield

Inactive Publication Date: 2013-05-01
SHANGHAI ZHANGJIANG ENG RES CENT OF MODERN PREPARATION TECH OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved in the present invention is to provide a method for preparing chuanxiong lactone I from the extract of Angelica sinensis, so as to solve the technical problems of cumbersome preparation means and extremely low yield in the prior art

Method used

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  • Method for preparing senkyunolide I from extract of Chinese angelica

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Experimental program
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Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Ligustilide I

[0021] Angelica decoction pieces 1kg, after removing impurities, pulverized into powder, the volume concentration is 95% ethanol 10L reflux extraction 2 times, each time 2 hours, combined extracts, recovered solvent to obtain about 200g of extract A.

[0022] Dilute the extract A to about 2000mL with deionized water (the concentration of the aqueous solution is equivalent to 0.5g·ml crude drug -1 ) and then put on HPD-100 macroporous resin column [the weight ratio of macroporous resin to raw medicinal material (danggui decoction pieces) is 0.3:1, the size of macroporous resin column is Φ150*1500mm], and the adsorption flow rate is 2BV h -1 , discard the eluent after eluting 6BV with deionized water, then elute 4BV with 50% ethanol with a volume concentration, collect the 50% ethanol eluate, and recover the solvent under reduced pressure to obtain about 30 g of extract B.

[0023] Disperse extract B with 100mL deionized wa...

Embodiment 2

[0026] The preparation of embodiment 2 Ligustilide I

[0027] Angelica decoction pieces 1kg, after removing impurities, pulverized into powder, the volume concentration is 95% ethanol 10L reflux extraction 2 times, each time 2 hours, combined extracts, recovered solvent to obtain about 200g of extract A.

[0028] Dilute the extract A to about 2000mL with deionized water (the concentration of the aqueous solution is equivalent to 0.5g·ml crude drug -1 ) on the HPD-100 macroporous resin column (the weight ratio of the macroporous resin to the original medicinal material is 0.3:1, the macroporous resin column specification Φ150*1500mm), and the adsorption flow rate is 1BV h -1 , discard the eluent after eluting 4BV with 10% ethanol, then elute 6BV with 40% ethanol with a volume concentration, collect the 40% ethanol eluate, reclaim the solvent under reduced pressure to obtain about 30 g of extract B.

[0029] Disperse extract B with 100mL deionized water (the concentration of th...

Embodiment 3

[0032] The preparation of embodiment 3 Ligustilide I

[0033] Angelica decoction pieces 1kg, after removing impurities, pulverized into powder, the volume concentration is 50% ethanol 10L reflux extraction 2 times, each time 2 hours, the extracts were combined, and the solvent was recovered to obtain about 200g of extract A.

[0034] Dilute extract A to about 1250mL with deionized water (the concentration of this aqueous solution is equivalent to crude drug 0.8g·ml-1 ) on the HPD-100 macroporous resin column (the weight ratio of the macroporous resin to the original medicinal material is 0.4:1, the macroporous resin column specification Φ150*1500mm), and the adsorption flow rate is 1.5BV h -1 , with a volume concentration of 5% ethanol to elute 5BV and then discard the eluent, then use a volume concentration of 45% ethanol to elute 5BV, collect the 45% ethanol eluate, reclaim the solvent under reduced pressure to obtain about 30g of extract B.

[0035] Disperse the extract B w...

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Abstract

The invention discloses a method for preparing senkyunolide I from extract of Chinese angelica, which comprises the following steps: (1) purifying by using macroporous resin; (2) purifying by extraction; and (3) purifying by chromatography. In the invention, the preparation process of the senkyunolide I is simplified, and the yield is increased to a great extent. In addition, the method prepares the senkyunolide I by using the extract of Chinese angelica which is a traditional Chinese medicine instead of Szechuan lovage rhizome which is an original source plant. Therefore, the method can be used in the industrial preparation of senkyunolide I.

Description

technical field [0001] The present invention relates to a method for preparing senkyunolide I (senkyunolide I), in particular to a method for preparing senkyunolide I from angelica sinensis (Oliv.) Diel extract. Background technique [0002] Angelica sinensis (Oliv.) Diel is a Umbelliferae plant, and its medicinal parts are rhizomes. Angelica is a traditional Chinese medicine in my country, which has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and relaxing bowels. Clinically, it is often used for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, abdominal pain due to deficiency and cold, constipation due to dryness of the intestine, arthralgia due to rheumatism, traumatic injuries, etc. [0003] Phthalides are a class of compounds present in Angelica sinensis, which have been proven to be active in cardiovascular, blood and smooth muscle, and can be considered as one of the ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/88
Inventor 阮克锋冯怡徐德生梁爽
Owner SHANGHAI ZHANGJIANG ENG RES CENT OF MODERN PREPARATION TECH OF TRADITIONAL CHINESE MEDICINE
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