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Lentinan granule as well as preparation method and use of lentinan granule

A technology of lentinan and granules, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of affecting growth and quality, inconvenient operation, and large irritation of animal organisms, etc. Stable content, reduced stress response, less hygroscopic effect

Active Publication Date: 2011-06-29
JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain limitations when the above-mentioned lentinan dosage forms are used in veterinary clinics. For example, the injection dosage forms are highly irritating to the animal body, and the animals are prone to stress, which affects growth and quality; the oral liquid dosage form is cumbersome to administer and inconvenient to operate; and There are also limitations in the application of dropping pills and enteric-coated capsules

Method used

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  • Lentinan granule as well as preparation method and use of lentinan granule
  • Lentinan granule as well as preparation method and use of lentinan granule
  • Lentinan granule as well as preparation method and use of lentinan granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 lentinan granules

[0024] Prepare as follows:

[0025] (1), Lentinan (purchased from Fuzhou Meifeng Pharmaceutical Factory of Jinling Pharmaceutical Co., Ltd., the specification is 10g / bottle (plastic bottle), and the approval number is Z1092011, the same below), powdered sugar (purchased from Shandong Xiangrui Pharmaceutical Co., Ltd., the specification is 25kg / bag, and the approval number is Guoyao Zhunzi H20013420, the same below), hypromellose (purchased from Anhui Shanhe Pharmaceutical Excipients Co., Ltd., the specification is 25kg / bag, approved Document number is Wanyao Zhunzi (2002) No. F0003), etc., and then dried and pulverized; lentinan was passed through a 100-mesh sieve, and sugar powder and hypromellose were passed through a 80-mesh sieve for later use.

[0026] (2) Put 50g of lentinan and 600g of powdered sugar in a mixer, then gradually add 300g of hydroxypropyl methylcellulose and 50g of water, and mix well to make a so...

Embodiment 2

[0027] The preparation of embodiment 2 lentinan granules

[0028] Prepare as follows:

[0029] (1), Lentinan, mannitol (purchased from Jiangsu Huanghai Pharmaceutical Co., Ltd., the specification is 25kg / bag, and the approval number is Guoyao Zhunzi H32022586), dextrin (purchased from Anhui Shanhe Pharmaceutical Excipients Co., Ltd., specification It is 25kg / bag, and the approval number is Wanyao Zhunzi (2002) No. F0001), etc., are dried separately, and pulverized; Lentinan is passed through a 100-mesh sieve, and mannitol and dextrin are passed through a 80-mesh sieve for later use;

[0030] (2) Put 30g of lentinan and 750g of mannitol in a mixer, gradually add 200g of dextrin and 20g of water, mix well to make a soft material; pass the soft material through a 16-mesh sieve to make wet granules, and then drum at 40°C After air-drying, use 20-mesh whole grains to obtain lentinan granules.

Embodiment 3

[0031] The preparation of embodiment 3 lentinan granules

[0032] Prepare as follows:

[0033] (1), Lentinan, powdered sugar, povidone K30 (purchased from Zhejiang Maoyuan Pharmaceutical Co., Ltd., the specification is 25kg / barrel, approval number Wenzhe Yao Zhun Zi (2004) No. 224602, the same below) Dried and crushed separately; lentinan was passed through a 100-mesh sieve, sugar powder and povidone K30 were passed through a 80-mesh sieve for later use;

[0034] (2) Put 50g of lentinan and 700g of powdered sugar in a mixer, gradually add 200g of povidone K30 and 50g of water, and mix well to make a soft material; pass the soft material through a 16-mesh sieve to make wet granules, and then 40°C After blast drying, use 20-mesh whole grains to obtain lentinan granules.

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Abstract

The invention discloses a lentinan granule comprising the following raw materials in percentage by weight: 0.5-5% of lentinan, 60-80% of filler, 10-30% of adhesive and 0.5-5% of water. The invention further discloses a preparation method of the lentinan granule and use of the lentinan granules in preparation of veterinary immune enhancing medicaments. The lentinan granule disclosed by the invention is conveniently used, can be swallowed directly and can also be dissolved in water for drinking, and further can be used as a feed additive; secondly, the lentinan granule disclosed by the invention can reduce the stress reactions of animal bodies caused by medicament administration; in addition, the lentinan granule disclosed by the invention has the advantages of small dispersion, adhesiveness, aggregation and hygroscopicity; and the content of medicament is stable.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a lentinan granule, a preparation method thereof and an application as a veterinary immune enhancer. Background technique [0002] Lentinan (LNT) is a homogeneous polysaccharide obtained by extracting, separating and purifying from the fruiting body of the fungus Lentinus edodes (Lentinus edodes), which has a variety of biological and immunological activities. Insects have universal resistance. Lentinan stimulates the maturation, differentiation and proliferation of immune cells, improves the balance of the host body, restores and improves the responsiveness of the host cells to lymphokines, hormones and other physiologically active factors, thereby enhancing the body's immunity. Lentinan has been widely used in human clinical treatment as an adjuvant therapy for anti-tumor, anti-virus, anti-radiation, anti-diabetes, and hypolipidemic (Lv Guoying et al. Zh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/715A61P37/04
Inventor 彭麟江善祥蔡冬万荣峰季辉张军忍施宗傲
Owner JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD
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