Compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof

Abstract

The invention discloses a compound pharmaceutical composition for improving oral bioavailability of taxol and application thereof. The invention also discloses a pharmaceutical composition containing the compound pharmaceutical composition and a taxol monomeric compound. The compound pharmaceutical composition provided by the invention can be used for improving the oral bioavailability of the taxol and can improve the anticancer effect of the taxol when used for preparing anticancer drugs. In the compound pharmaceutical composition provided by the invention, the taxol is the main anticancer component, and the traditional Chinese medicine extract monomeric compound improves the oral bioavailability and the anticancer effect of the taxol by inhibiting the first-pass effect of the taxol. Shown by experimental study, the compound pharmaceutical composition provided by the invention can be prepared into an oral medicament to improve the blood concentration and the anticancer effect of the taxol after oral administration.

Description

A compound pharmaceutical composition for improving paclitaxel oral bioavailability and application thereof technical field The invention relates to the field of pharmaceutical compositions, in particular to a compound pharmaceutical composition for improving the oral bioavailability of paclitaxel and its application. Background technique Paclitaxel, as a chemotherapy and anticancer drug with a special mechanism, is clinically used to treat a variety of malignant tumors, such as ovarian cancer, cervical cancer, breast cancer, laryngeal cancer, and esophageal cancer. Currently, paclitaxel preparations used clinically are injections. Due to the low solubility of paclitaxel in water, most of the injections currently used use polyoxyethylene castor oil / absolute ethanol (1:1, v / v) as excipients to increase the solubility of paclitaxel. , diluted with glucose or normal saline solution before use (Yang Tao, Wu Zongqun. Progress in Experimental and Clinical Application of Antitumo...

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Problems solved by technology

The three major metabolites are not cytotoxic to tumor cells, but are cytotoxic to human bone marrow cells (HenningssonA, KarlssonMO, ViganoL, GianniL, VerweijJ, SparreboomA.Mechanism-basedpharmacokineticmodelforpaclitaxel.JClinOncol2001;19(20):4065-73)

However, there is no report on the compatibility of traditional Chinese medicine monomers and paclitaxel to make a compound preparation (pharmaceutical composition) with a clear mechanism

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