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Medicine composition, application and preparation thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its use and preparation, and can solve problems such as the influence of drug efficacy

Active Publication Date: 2011-06-01
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many kinds of chemical components in traditional Chinese medicine, which components have biological activity, which active components play the main role, how the various chemical components interact, and how they affect the efficacy of medicine, etc. Many problems have not yet been well resolved

Method used

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  • Medicine composition, application and preparation thereof
  • Medicine composition, application and preparation thereof
  • Medicine composition, application and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation of ancestral hemp extract

[0049] Extraction: Weigh 2Kg of Zushima medicinal material, decoct with 20L, 16L and 16L water respectively and filter 3 times, decoct for 1 hour each time, and combine the filtrates;

[0050] Concentration: Concentrate the extracted filtrate under reduced pressure to obtain a clear paste;

[0051] Alcohol precipitation: add absolute ethanol to the clear ointment to make the ethanol concentration reach 60% by weight, and filter to remove insoluble impurities after standing for 12 hours;

[0052] Drying: the filtrate was distilled under reduced pressure to recover ethanol, then vacuum-dried, and the solid obtained after drying was pulverized to obtain 185 grams of zulms extract, which was recorded as A1.

[0053] Content measurement

[0054] (1) HPLC determination of daphnetin, daphnetin, daphnetin-8-O-glucoside and 7-OH-coumarin:

[0055] The chromatographic column uses octadecylsilane bonded silica gel as a filler, and methano...

Embodiment 2

[0063] Preparation of ancestral hemp extract

[0064] Extraction: Weigh 2Kg of Zushima medicinal material, decoct with 20L, 16L and 16L water respectively and filter 3 times, decoct for 1 hour each time, and combine the filtrates;

[0065] Concentration: Concentrate the extracted filtrate under reduced pressure to obtain a clear paste;

[0066] Extraction: extract the clear paste with n-butanol (5×200ml), and combine the extracts;

[0067] Drying: Recover n-butanol by distillation under reduced pressure, then carry out vacuum drying, and pulverize the solid obtained after drying to obtain 208 grams of zulmae extract, which is recorded as A2.

[0068] Determination of content: measured according to the same method as in Example 1, the contents of Daphnetin, Zuma B, Daphnetin-8-O-glucoside and 7-OH-coumarin in A2 were measured to be 4.1% by weight, 15.2% by weight, 12.0% by weight and 1.9% by weight, the content of active ingredients of Zushi mocoumarins is 36.2% by weight, an...

Embodiment 3

[0070] Preparation of ancestral hemp extract

[0071] Extraction: Weigh 2Kg of zushima medicinal material, reflux and filter with 20L, 16L and 16L of 50% by weight ethanol respectively, reflux for 1 hour each time, and combine the filtrates;

[0072] Concentration: Concentrate the extracted filtrate under reduced pressure to obtain a clear paste;

[0073] Adsorption: Add 2L of water to the concentrated clear paste, pass through AB-8 macroporous resin, and then rinse with 2L of water;

[0074] Elution: elute the extract adsorbed on the resin with 4L of 50% by weight ethanol;

[0075] Drying: The eluent was distilled under reduced pressure to recover ethanol, and then vacuum-dried, and the solid obtained after drying was pulverized to obtain 120 grams of zushima extract, which was recorded as A3.

[0076] Determination of content: measured according to the same method as in Example 1, the contents of Daphnetin, Zuma B, Daphnetin-8-O-glucoside and 7-OH-coumarin in A3 were measu...

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Abstract

The invention provides a medicine composition, application and a preparation thereof. The composition contains a girald daphne bark extract, a white paeony root extract and / or a radix paeoniae rubra extract, wherein the ratio of the weight of the girald daphne bark extract to the total weight of the white paeony root extract and the radix paeoniae rubra extract is 1:20-20:1. According to a Chinese medicine theory and a prescription-formulating principle of Chinese medicine components, the girald daphne bark extract and the white paeony root extract are combined according to a certain proportion and generate a synergistic effect to prepare a medicine for treating diseases which take inflammatory response and pain as a main clinical symptom, i.e. rheumatism pain, rheumatoid arthritis pain, bone disease pain and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition, its anti-inflammatory and analgesic application, and a preparation containing the pharmaceutical composition. Background technique [0002] At present, most of the chemical research of traditional Chinese medicine is the research on the components of traditional Chinese medicine, including the extraction, separation, structure identification and pharmacological action of the components, and a large amount of data has been accumulated in these aspects. However, the research on the chemical components of traditional Chinese medicine is still relatively lagging behind, and the understanding of the material basis of traditional Chinese medicine and compound prescriptions and the relationship between them and their efficacy is still not very clear. There are many kinds of chemical components in traditional Chinese medicine, which components have biological activity, which active components play the main...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P29/00
Inventor 马莉韩峰高静申秀萍刘静
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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