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Preparation method and applications of sugar-reducing effective part of chicory

A technology for use and medicinal salt is applied to the preparation of the effective hypoglycemic part of chicory and the field of use thereof, which can solve the problems of reducing the blood uric acid level of model animals, and the pharmacological action mechanism is not mentioned.

Active Publication Date: 2011-06-01
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liu Xiaoqing and others used a quail hyperuricemia model similar to human metabolism to prove that a small dose of chicory extract can significantly reduce the blood uric acid level of model animals. Chicory extract has a significant effect of lowering uric acid, but the pharmacological mechanism is not mentioned.

Method used

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  • Preparation method and applications of sugar-reducing effective part of chicory
  • Preparation method and applications of sugar-reducing effective part of chicory
  • Preparation method and applications of sugar-reducing effective part of chicory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 10Kg of the above-ground part of chicory, pulverize it, put it in a 50L extraction tank, and extract it by cold soaking at room temperature with 70% ethanol aqueous solution for 6 times, each time is 24 hours, the solid-liquid ratio is 1:2, and the extracts are combined;

[0027] Place the extract in a rotary evaporator to concentrate under reduced pressure, add 1% ethanol aqueous solution to dissolve and disperse, add the pre-treated macroporous resin AB-8 column for adsorption, and then use water at a concentration of 10%, 30%, and 95%. Gradient elution with methanol solution, 30-95% of the effluent was collected and concentrated to obtain 110 g of effective fractions with hypoglycemic activity.

Embodiment 2

[0029] Take 4Kg of the aboveground part of chicory, pulverize it, put it in a 50L extraction tank, and extract it by cold soaking with 95% ethanol aqueous solution at a temperature of 20°C for 3 times, each time is 24 hours, and the solid-to-liquid ratio is 1:10, and the extracts are combined;

[0030]Place the extract in a rotary evaporator to concentrate under reduced pressure, add an aqueous solution to dissolve and disperse, add it to a pre-treated macroporous resin HPD600 column for adsorption, and then elute with water, ethanol solution with a concentration of 10%, 30%, and 95%, and collect 30-95% of the effluent can be concentrated to obtain 35g of effective fractions with hypoglycemic activity.

Embodiment 3

[0032] Take 10Kg of the aboveground part of chicory, crush it, put it in a 50L extraction tank, extract it with absolute ethanol, heat it to the boiling point of the solvent and extract it 3 times, each time for 4 hours, the solid-liquid ratio is 1:4, and combine the extracts;

[0033] Place the extract in a rotary evaporator to concentrate under reduced pressure, add 10% ethanol aqueous solution to dissolve and disperse, add pre-treated macroporous resin D301 column for adsorption, water, 10%, 30%, 95% ethanol solution Gradient elution, 30-95% of the effluent is collected, and after concentration, 130 g of effective fractions with hypoglycemic activity can be obtained.

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Abstract

The invention relates to a preparation method and applications of a sugar-reducing effective part of chicory. In the method, organic solvent extraction and macroporous resin separation and purification are adopted in crude chicory to obtain the sugar-reducing effective part, and the medical applications of the sugar-reducing effective part are illuminated. The preliminary activity screening test proves that the effective part obtained by the method provided by the invention has protein tyrosine phosphatase (PTP1B) inhibitor action, and the animal experiment proves that the effective part has the activity of reducing sugar and fat. The effective part can be used for preparing medicines or health products for treating diabetes, and can be used as a pharmaceutical composition.

Description

technical field [0001] The present invention relates to the preparation and application of a hypoglycemic effective fraction in chicory, in particular to the use of active ingredients extracted from chicory as medicine for treating diabetes and functional food. Background technique [0002] Chicory According to the Chinese Pharmacopoeia, "Chicory" specifically refers to Cichorium glandulosum Bioss. et Huet. and Chicory (Cichorium intybus L.). Chicory is a plant with a wide range of uses. Italian residents use chicory leaves to make vegetable salads, which are delicious. In addition, chicory has a lot of medicinal value. [0003] Chicory is a commonly used medicinal material of the Uygur nationality. It has the effects of clearing the liver and gallbladder, invigorating the stomach and eliminating food, diuresis and swelling. It is used for damp-heat jaundice, stomach pain, lack of food, edema and oliguria. [0004] Type II diabetes is a common chronic disease among middle-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A23L1/29A61P3/10A23L33/00
Inventor 阿吉艾克拜尔·艾萨信学雷赵海清吴涛杨伟俊张尧
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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