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Medical pressure-sensitive adhesive composition

A technology of composition and adhesive, which is applied in the direction of medical preparations of non-active ingredients, medical science, pharmaceutical formula, etc., can solve problems such as detachment, and achieve the effect of denaturation inhibition

Active Publication Date: 2014-07-23
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the patch may be detached from the skin when it is attached to the skin surface for a long time or when it is attached to a skin surface that moves greatly, the adhesive properties of the carboxyl- and sulfo-group-free adhesives disclosed in this document needs additional improvement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] [Example 1] Adhesive composition

[0071] First, 70 parts of 2-ethylhexyl acrylate (hereinafter referred to as "2-EHA") as monomer (a), 10 parts of N-hydroxyethylacrylamide as monomer (b) (hereinafter referred to as is "HEAA"), 20 parts of N-vinyl-2-pyrrolidone (hereinafter may be referred to as "N-VP") as a monomer (c), and 333.3 parts of ethyl acetate as a solvent are charged into a cooling tube, nitrogen guide tube, thermometer, dropping funnel, and stirrer, then the contents were stirred at room temperature for 1 h while nitrogen sparging (100 mL / min). After that, the contents in the reaction vessel were heated, and when the temperature of the contents reached 60°C, 0.2 parts of 2,2'-azobisisobutyronitrile (AIBN) was added as a polymerization initiator. The temperature of the contents was controlled so as to be kept at 60° C., and then polymerization was performed in a nitrogen stream for 6 hours. Next, the temperature was maintained at 76°C for 15 hours. Based o...

Embodiment 2

[0072] [Example 2] Adhesive composition

[0073] Using 85 parts of 2-ethylhexyl acrylate as monomer (a), 10 parts of N-hydroxyethylacrylamide as monomer (b) and 5 parts of N-vinyl-2 as monomer (c) - An adhesive composition (2-EHA / HEAA / N-VP=85 / 10 / 5) was prepared as an acrylic copolymer solution in the same manner as in Example 1 except that pyrrolidone was used as a monomer component. .

Embodiment 3

[0074] [Example 3] Adhesive composition

[0075] Using 50 parts of 2-ethylhexyl acrylate as monomer (a), 10 parts of N-hydroxyethylacrylamide as monomer (b) and 40 parts of N-vinyl-2 as monomer (c) - Pyrrolidone was used as a monomer component, and an adhesive composition as an acrylic copolymer solution (2-EHA / HEAA / N-VP=50 / 10 / 40 ).

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Abstract

The present invention provides a medical adhesive composition, which contains an acrylic copolymer, the acrylic copolymer containing (a) at least one alkyl (meth)acrylate monomer and (b) at least one A monomer component of N-hydroxyalkyl (meth)acrylamide monomer is obtained by copolymerization, wherein: the content of the above-mentioned alkyl (meth)acrylate monomer (a) is relative to the total amount of the above-mentioned monomer component is 50% by weight to 99.9% by weight, and the content of the above-mentioned N-hydroxyalkyl (meth)acrylamide monomer (b) is 0.1% by weight to 20% by weight relative to the above-mentioned total amount; and the above-mentioned monomer component is substantially Does not contain monomers with carboxyl groups. The medical adhesive composition of the present invention is particularly suitable for applications such as medical patches and patch preparations.

Description

[0001] This application claims priority under 35 U.S.C. Chapter 119 to Japanese Patent Application No. 2009-265718 filed on November 20, 2009, which is incorporated herein by reference. technical field [0002] The present invention relates to a medical adhesive composition which can be suitably used for medical patches or patch preparations. Background technique [0003] Both patches and patch preparations are required to have the following characteristics. The above-mentioned patches and patch preparations are all attached to the skin to achieve purposes such as protecting the skin, fixing various medical devices, and transdermally administering drugs. That is, patches and patch preparations exhibit sufficient adhesiveness when attached to the skin, and can be peeled off and removed without contaminating the skin surface (causing, for example, adhesive residue or stickiness) after its use . In addition, there is a need for both the patch and the patch preparation to be le...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K9/70A61L15/58
CPCA61L15/58C08L33/26
Inventor 石仓准舟山赖人立川悠关谷纯一笠原刚冈本昌之丹羽理仁
Owner NITTO DENKO CORP
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