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Traditional Chinese medicinal composition for treating cardiovascular diseases and preparation method thereof

A technology of composition and traditional Chinese medicine, applied in the direction of cardiovascular system diseases, drug combinations, metabolic diseases, etc., can solve problems such as severe toxicity and side effects, unsuitable for long-term medication, slow onset of active ingredients, etc.

Inactive Publication Date: 2011-05-18
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional western medicines used are nitrates, nitrites, β-receptor blockers, calcium antagonists, etc., which have a rapid onset of effect, but they all have relatively large toxic and side effects. No major effect on disease progression
In terms of traditional Chinese medicine, the active ingredients of traditional dosage forms such as tablets and capsules have a slow onset of action and low bioavailability; injections have a quick onset of action, but are not suitable for long-term medication; Suxiao Jiuxin pills, etc. have achieved certain clinical application effects, but their indications are relatively single and cannot meet the needs of clinical multi-diseases
Through the research on the drugs for the treatment of coronary heart disease and angina pectoris in the market, it is found that the main varieties such as capsules, tablets, injections, and drop pills involved in the market are mostly blood circulation promoting and blood stasis dispelling and analgesic drugs, which are mainly for blood stasis type coronary heart disease angina pectoris, while for phlegm There are few drugs for stasis-type diseases, so there is a need for a safe, quick-acting and reliable drug for angina pectoris of phlegm-stasis type to make up for the deficiency of existing drugs

Method used

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  • Traditional Chinese medicinal composition for treating cardiovascular diseases and preparation method thereof
  • Traditional Chinese medicinal composition for treating cardiovascular diseases and preparation method thereof
  • Traditional Chinese medicinal composition for treating cardiovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Prescription: Gualoupi 90g, Xiongbai 90g, Chuanxiong 80g, Panax notoginseng 30g, Salvia miltiorrhiza 80g, borneol 1g

[0095]Preparation method: take the above six flavors, take scallions, reflux twice with 4 times the amount of 95% ethanol, 1.5 hours each time, filter, recover ethanol under reduced pressure, concentrate to 60°C and measure the thick ointment with a relative density of 1.30-1.35; dregs Mix it with Trichosanthes rind, Chuanxiong, Panax notoginseng, Salvia miltiorrhiza, add 4 times the amount of 50% ethanol to reflux twice, each time for 1.5 hours, filter, recover ethanol under reduced pressure, add ethanol to 75% alcohol content, let it stand, Recover ethanol from the supernatant, concentrate to 60°C and measure a thick paste with a relative density of 1.35-1.40, add borneol and the above-mentioned Allium scallions thick paste, mix well, add 70°C molten matrix (PEG4000: PEG6000 = 1:1), stir well, keep warm, drop into simethicone at about 10°C, centrifuge...

Embodiment 2

[0097] Prescription: Gualou 60g, Xiongbai 60g, Chuanxiong 120g, Panax notoginseng 60g, Salvia miltiorrhiza 50g, natural borneol 5g

[0098] Preparation method: take the above six flavors, take scallions, reflux with 6 times the amount of 50% ethanol for 4 times, each time for 0.5 hours, filter, recover ethanol under reduced pressure, concentrate, and dry; mix the dregs with Trichosanthes melon, Chuanxiong, Panax notoginseng, and Salvia miltiorrhiza , add 4 times the amount of 30% ethanol to reflux 3 times, each time for 1 hour, filter, recover ethanol under reduced pressure, add ethanol to 70% alcohol content, let it stand, recover ethanol from the supernatant, concentrate, dry, add natural The borneol and the above-mentioned scallion dry powder are pulverized, an appropriate amount of starch is added, mixed evenly, and capsules are obtained.

Embodiment 3

[0100] Prescription: Gualou skin 120g, Xibai 120g, Chuanxiong 90g, Panax notoginseng 50g, Salvia miltiorrhiza 120g, natural borneol 1g

[0101] Preparation method: take the above six flavors, take scallion white, reflux twice with 5 times the amount of 95% ethanol, 1 hour each time, filter, recover ethanol under reduced pressure, concentrate, and dry; medicine dregs, Gualou skin, Chuanxiong, Panax notoginseng, Salvia miltiorrhiza Mix, add 5 times the amount of 50% ethanol to reflux twice, each time for 1 hour, filter, recover ethanol under reduced pressure, add ethanol until the alcohol content is 75%, let it stand, recover ethanol from the supernatant, concentrate, dry, add Natural borneol and the above dry powder of scallion, crushed, mixed, added to PEG6000 melted at 80°C in a weight ratio of 3:7, fully stirred, kept warm, dropped into simethicone oil at about 10°C, centrifuged, dried, and selected Pills, that is.

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating cardiovascular diseases and belongs to the field of traditional Chinese medicaments. The traditional Chinese medicinal composition is prepared by the following steps of: extracting active ingredients from raw material medicaments, such as pericarpium trichosanthis, longstamen onion bulb, szechuan lovage rhizome and the like, by adopting the methods of different-concentration ethanol extraction, water extraction and the like respectively according to different properties of the medicaments; and preparing dropping pills, soft capsules, capsules, tablets and pills. The traditional Chinese medicinal composition is clinically used for treating diseases such as a coronary heart disease, angina pectoris, hyperlipidaemia, atherosclerosis and the like. The invention also discloses a preparation method of the traditional Chinese medicinal composition.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, in particular to a traditional Chinese medicine composition for coronary heart disease, angina pectoris, hyperlipidemia and atherosclerotic diseases and a preparation method thereof. Background technique [0002] Coronary heart disease and angina pectoris are caused by insufficient coronary blood supply and sudden and temporary ischemia and hypoxia of the myocardium, which belong to the category of "chest pain" in traditional Chinese medicine. Since the 1950s, coronary heart disease and angina pectoris have become the third leading cause of death in humans besides cerebrovascular diseases and malignant tumors. Their prevention and in-depth research have always been the focus in the field of medicine. [0003] At present, the methods for treating coronary heart disease and angina pectoris mainly focus on dilating ...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P3/06A61P9/10A61K31/045
Inventor 孙志强代龙
Owner 北京凯瑞创新医药科技有限公司
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