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Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat

A composition and drug technology, applied in the field of medicine, can solve the problems of undiscovered prevention and treatment, undiscovered, etc., and achieve the effects of high development and utilization value, short production cycle, and strong operability

Active Publication Date: 2012-05-30
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Before the completion of the present invention, there was no literature report on the pharmaceutical composition composed of peltaside, syringin, and syringic acid, which can prevent and treat alcoholic liver damage, alcoholic fatty liver, non-alcoholic fatty liver and There are no reports of hyperlipidemia, and no clinical application of this composition for the prevention and treatment of alcoholic liver injury, alcoholic fatty liver, non-alcoholic fatty liver and hyperlipidemia has been found
At the same time, no composition consisting of glucoside, syringin, and syringic acid extracted from other natural Chinese medicinal materials has been found.

Method used

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  • Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat
  • Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat
  • Application of medicinal composition to preparation of medicament for preventing and treating alcoholic liver damage and fatty liver and lowering blood fat

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0059] Crushed 2kg of the medicinal materials of Jubingying into coarse powder, extracted 3 times with 70% ethanol of 8 times the weight of the medicinal materials, 2 hours each time, filtered, combined the filtrates, recovered the ethanol to 2500ml, filtered, and took the filter cake Extract I was obtained; the filtrate was evaporated to no alcohol smell, passed through the treated D101 macroporous resin column, washed with water until colorless, then eluted 4BV with 50% ethanol, collected the ethanol eluent, recovered ethanol, concentrated, The extract II was obtained; the extract I and the extract II were combined and dried to obtain 158.6 g of the Salvation Bing pharmaceutical composition. Measured by high performance liquid chromatography and calculated, syringin accounted for 23.8%, holothin accounted for 59.1%, and salvage acid accounted for 2.9%.

example 2

[0061] Crushed 2kg of the medicinal materials of Jubiying into coarse powder, extracted 3 times with 50% ethanol of 6 times the weight of the medicinal materials, each time for 3 hours, filtered, combined the filtrates, recovered the ethanol to 2500ml, filtered, and took the filter cake Extract I was obtained; the filtrate was evaporated to no alcohol smell, passed through the treated D101 macroporous resin column, washed with water until colorless, then eluted 4BV with 60% ethanol, collected the ethanol eluent, recovered ethanol, concentrated, The extract II was obtained; the extract I and the extract II were combined and dried to obtain 168.4 g of the Salvage Bing pharmaceutical composition. Measured by high performance liquid chromatography and calculated, syringin accounted for 19.7%, holothin accounted for 55.3%, and salvage acid accounted for 2.2%.

example 3

[0063] Crushed 2 kg of the medicinal materials of Jubiying into coarse powder, extracted twice with 80% ethanol of 8 times the weight of the medicinal materials, 3 hours each time, filtered, combined the filtrates, recovered the ethanol to 2500 ml, filtered, and took the filter cake Extract I was obtained; the filtrate was evaporated to no alcohol smell, passed through the treated AB-8 macroporous resin column, washed with water until colorless, then eluted 4BV with 40% ethanol, collected the ethanol eluent, and recovered ethanol, Concentrate to obtain extract II; combine extract I and extract II, and dry to obtain 148.6 g of Salvation Bing pharmaceutical composition. Measured by high performance liquid chromatography, it was calculated that syringin accounted for 23.4%, holothin accounted for 60.1%, and salvage acid accounted for 3.4%. Example 4

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PUM

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Abstract

The invention discloses an ilicis routundae cortex medicinal composition for preventing and treating alcoholic liver damage, alcoholic fatty liver, non-alcoholic fatty liver and hyperlipidemia. The composition is extracted and refined from natural ilicis routundae cortex and is not chemically modified, and is characterized by comprising substances such as pedunculoside, syringin, rotundicacid andthe like. The invention also discloses a preparation method of the ilicis routundae cortex composition and application to preparation of a medicament for preventing and treating the alcoholic liver damage, the alcoholic fatty liver and the non-alcoholic fatty liver and lowering blood fat.

Description

technical field [0001] The invention relates to a new method and medical application of a pharmaceutical composition extracted from Ilicis routundae cortex, in particular to a new method for preventing and treating alcoholic liver damage, alcoholic fatty liver, non-alcoholic A pharmaceutical composition for fatty liver and hyperlipidemia. It also relates to the pharmaceutical preparation of the medicine, and the invention belongs to the technical field of medicine. Background technique [0002] Fatty liver is not an independent disease, it is liver steatosis caused by a variety of diseases and etiologies. The most common causes are obesity and alcoholism, followed by nutritional disorders, diabetes, drug poisoning, pregnancy, and genetics. Liver steatosis can affect liver function, and some patients may further develop hepatitis, liver fibrosis and cirrhosis. The incidence of fatty liver in my country is gradually increasing. Although there is no disease name for fatty l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P1/16A61K31/56A61K31/7034A61K31/7042
Inventor 赵全成南敏伦赫玉芳赵昱玮王莲萍李刚
Owner 吉林修正药业新药开发有限公司
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