Traditional Chinese medicine composition for treating acute myeloblastic leukemia (AML) M1

Abstract

The invention provides a traditional Chinese medicine composition for treating acute myeloblastic leukemia (AML) M1. The composition is prepared from the following components: 15-25g of radix rehmanniae, 8-16g of cortex moutan, 4-8g of honey-fried liquorice, 18-32g of oldenlandia diffusa, 14-20g of lalang grass rhizome, 18-28g of glossy privet fruit, 14-28g of herba cistanche, 4-8g of cordyceps sinensis, 15-25g of folium isatidis, 8-16g of wild radix ophiopogonis and 8-16g of honeysuckle. The medicine provided by the invention has the following functions: pertinently treating specific AML-M1, selectively inhibiting and killing immature cells, inducing leukemia cell apoptosis and having stronger pertinence and higher treatment effect; promoting differentiation and maturity of leukemia cells; regulating qi and blood and enhancing immunity; promoting recovery of normal hematopoietic function of marrows; and reducing reversion and preventing medicine resistance.

Description

[0001] The invention relates to a medicine for treating leukemia, in particular to a traditional Chinese medicine composition for treating acute granulocytic AML-M1 leukemia. Background technique [0002] Leukemia is A malignant clonal disease of hematopoietic stem cells, characterized by the diffuse proliferation of abnormal white blood cells (leukemic cells) in the bone marrow to replace normal bone marrow tissue and invade the surrounding blood, resulting in quantitative and qualitative changes in the white blood cells in the peripheral blood. The number of white blood cells in the blood is often significantly increased, but sometimes it can be normal or even decreased. Leukemic cells can extensively infiltrate various tissues and organs throughout the body, such as the liver, spleen, and lymph nodes, and often cause anemia and hemorrhage. [0003] According to the statistics of the Ministry of Health, in 2009, the annual incidence rate of leukemia in my country was 3.99 / ...

AI Technical Summary

Problems solved by technology

However, this method has great side effects, such as killing and inhibiting normal hematopoietic stem cells, leading to anemia and bleeding, suppressing normal immune function, reducing body immunity, and easily merging with various infections, damaging the gastrointestinal mucosa, leading to anorexia, nausea, and vomiting. Affects heart, liver and kidney functions. No matter how high the dose is, it is impossible to completely kill leukemia cells in the body, and the residual leukemia cells are the root cause of disease recurrence.

This not only brings great pain to the patients themselves, but also causes heavy mental burden and economic losses to their families and society.