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Gentamycin sulfate capsule and preparation method thereof

A technology of gentamicin sulfate and capsules, which is applied in the fields of capsule transportation, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problems of difficult filling of capsules and unstable quality, and achieve fast dissolution rate and good stability , fast disintegration effect

Active Publication Date: 2011-05-11
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The gentamicin sulfate capsules on the market have always been widely used in many pharmaceutical manufacturers due to the technical problems of capsule filling and unstable quality. The production method of gentamicin capsule

Method used

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  • Gentamycin sulfate capsule and preparation method thereof
  • Gentamycin sulfate capsule and preparation method thereof
  • Gentamycin sulfate capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Composition:

[0034] composition

Weight (g)

percentage(%)

Gentamicin Sulfate

750

30.61

starch

700

28.57

microcrystalline methyl cellulose

200

8.16

Calcium sulfate

500

20.44

Hypromellose

100

4.08

Magnesium stearate

200

8.16

total

2450

100

[0035] 2. Preparation method:

[0036] 1) Weigh gentamicin sulfate, microcrystalline cellulose, starch, and calcium sulfate according to the prescription, then pulverize them respectively, dry them for 2 hours at a temperature of 55° C., and pass through a 100-mesh sieve;

[0037] 2) Mix gentamicin sulfate, microcrystalline methyl cellulose, starch, and calcium sulfate powder uniformly according to the method of equal addition, and the powder after mixing is white or off-white powder;

[0038] 3) Hypromellose is prepared into a concentration of 5% as an adhesive to make a soft material, ...

Embodiment 2

[0041] 1. Composition:

[0042] composition

Weight (g)

percentage(%)

Gentamicin Sulfate

750

27.27

pregelatinized starch

1100

40

microcrystalline methyl cellulose

200

7.27

Calcium sulfate

400

14.55

Hypromellose

100

3.64

[0043] silica

200

7.27

total

2750

100

[0044] 2. Preparation method:

[0045] 1) Weigh gentamicin sulfate, microcrystalline cellulose, pregelatinized starch, and calcium sulfate according to the composition, then pulverize them respectively, dry them for 2 hours at a temperature of 60° C., and pass through a 100-mesh sieve;

[0046] 2) Mix gentamicin sulfate, microcrystalline methyl cellulose, pregelatinized starch, and calcium sulfate powder evenly according to the method of equal addition, and the powder after mixing is white or off-white powder;

[0047] 3) Hypromellose is prepared into a concentration of...

Embodiment 3

[0050] 1. Composition:

[0051] composition

Weight (g)

percentage(%)

Gentamicin Sulfate

750

27.27

starch

1400

50.91

microcrystalline methyl cellulose

20

0.73

Calcium sulfate

200

7.27

Hypromellose

20

0.73

talcum powder

360

13.09

total

2750

100

[0052] 2. Preparation method:

[0053] 1) Weigh gentamicin sulfate, microcrystalline cellulose, starch, and calcium sulfate according to the composition, then pulverize them respectively, dry them at 60°C for 2 hours, and pass through a 100-mesh sieve;

[0054] 2) Mix the mixed powder of gentamicin sulfate and microcrystalline methyl cellulose with the mixed powder of starch and calcium sulfate according to the method of equal increase, and the mixed powder is white or off-white powder;

[0055] 3) Hypromellose is prepared into a concentration of 5% as an adhesive to make a soft material, and th...

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Abstract

The invention relates to a gentamycin sulfate capsule which is prepared by the following raw materials in percent by weight: 20-40 percent of gentamycin sulfate, 20-65 percent of starch, 5-25 percent of calcium sulfate, 0.5-10 percent of microcrystalline cellulose, 0.5-5 percent of hydroxy propyl methyl cellulose and 5-20 percent of lubricating agent. The capsule adds the stability of gentamycin sulfate, also avoids the bitterness of gentamycin sulfate, and increases the compliance of patients.

Description

technical field [0001] The invention relates to a capsule preparation of medicines, in particular to a gentamicin sulfate capsule and a preparation method thereof. Background technique [0002] Gentamicin sulfate is an aminoglycoside broad-spectrum antibiotic produced by Micromonospora. It is a multi-component antibiotic, and its sulfate is commonly used. [0003] Gentamicin hinders the initiation of protein synthesis by inhibiting the formation of the 70S synthesis initiation complex and causing the dissociation of N-methionyl-tRNA from the 70S synthesis initiation complex, so it has antibacterial and bactericidal effects on All kinds of Gram-negative bacteria and Gram-positive bacteria have good antibacterial effect, and have good antibacterial effect on various Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacteriaceae Bacillus, Serratia and Pseudomonas aeruginosa have good antibacterial effect. Neisseria and Haem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/7036A61K47/38A61P31/04
Inventor 杜明松张勇
Owner 蚌埠丰原涂山制药有限公司
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