Rapamycin microemulsion injection for eyes and preparation method and application thereof
A technology of rapamycin and injection, applied in the field of rapamycin ophthalmic microemulsion injection and preparation thereof, can solve the problem of lack of theoretical knowledge of age-related macular degeneration and other types of retinal degeneration diseases, etc.
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Embodiment 1
[0048] Rapamycin original drug provided by Tianjin Xinmei Technology Co., Ltd.
[0049] Prescription: Rapamycin (rapamycin) 1.00g;
[0050] 10.0ml soybean oil;
[0051] Tween-80 80.0ml;
[0052] Polyethylene glycol-400 64.0ml;
[0053] Appropriate amount of sterile water for injection;
[0054] The total amount prepared: 1000ml, the measured pH value is 7, the osmotic pressure: the osmotic pressure of 0.9% sodium chloride solution.
[0055] Process:
[0056] Precisely weigh Rapamycin, put it in a mortar, add soybean oil and Tween-80, grind it thoroughly until the powder is dissolved, and mix well; take another amount of PEG-400 and add it to 800ml sterile water for injection, boil to dissolve, stir to mix After uniformity, pour it into the above mixed solution, stir rapidly, adjust the volume to 1000ml with sterilized water for injection, filter through a 0.45 μm microporous membrane after mixing, and pack aseptically to obtain the product.
Embodiment 2
[0058] Rapamycin original drug provided by Tianjin Xinmei Technology Co., Ltd.
[0059] Prescription: Rapamycin (rapamycin) 1.15g;
[0060] 8.0ml soybean oil;
[0061] Tween-80 90.0ml;
[0062] Polyethylene glycol-400 70.0ml;
[0063] Appropriate amount of sterile water for injection;
[0064] The total amount prepared: 1000ml, the measured pH value is 6.5, the osmotic pressure: the osmotic pressure of 0.8% sodium chloride solution.
[0065] Process:
[0066] Precisely weigh Rapamycin, put it in a mortar, add soybean oil and Tween-80, grind it thoroughly until the powder is dissolved, and mix well; take another amount of PEG-400 and add it to 700ml sterile water for injection, boil to dissolve, stir to mix After uniformity, pour it into the above mixed solution, stir rapidly, adjust the volume to 1000ml with sterilized water for injection, filter through a 0.45 μm microporous membrane after mixing, and pack aseptically to obtain the product.
Embodiment 3
[0068] Rapamycin original drug provided by Tianjin Xinmei Technology Co., Ltd.
[0069] Prescription: Rapamycin (rapamycin) 0.85g;
[0070] 12.0ml soybean oil;
[0071] Tween-80 70.0ml;
[0072] Polyethylene glycol-400 58.0ml;
[0073] Appropriate amount of sterile water for injection;
[0074] Preparation volume: 1000ml, measured pH value is 7.5, osmotic pressure: 1.0% sodium chloride solution osmotic pressure.
[0075] Process:
[0076] Precisely weigh Rapamycin, put it in a mortar, add soybean oil and Tween-80, grind it thoroughly until the powder is dissolved, and mix well; take another amount of PEG-400 and add it to 800ml sterile water for injection, boil to dissolve, stir to mix After uniformity, pour it into the above mixed solution, stir rapidly, adjust the volume to 1000ml with sterilized water for injection, filter through a 0.45 μm microporous membrane after mixing, and pack aseptically to obtain the product.
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