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Formula of compound medicine preparation for relieving cough and preventing asthma and preparation method thereof

A technology of solid pharmaceutical preparations and compound prescriptions, which is applied in the fields of drug combinations, active ingredients of heterocyclic compounds, respiratory diseases, etc.

Inactive Publication Date: 2011-03-02
岳阳新华达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its effect on alleviating airway hyperresponsiveness is much lower than that of ketotifen fumarate. Therefore, when treating cough and asthma, clinicians often use ketotifen fumarate preparations together with compound methoxyphenamine capsules. Combination medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Weigh 12.5 g of methoxyphenamine hydrochloride, 7 g of narcotine, 25 g of aminophylline, and 1 g of ketotifen fumarate to prepare a powder according to the following method.

[0115] Take by weighing auxiliary materials micropowder silica gel 7g, dextrin 100g, aspartame 2g auxiliary materials. The raw and auxiliary materials are respectively crushed through a 100-mesh sieve, and set aside. Mix 1 g of ketotifen fumarate and 7 g of micropowder silica gel in equal increments, add 7 g of narcotin and mix evenly, add 12.5 g of methoxyphenamine hydrochloride and mix evenly, then add 25 g of aminophylline and mix evenly to obtain Compound oral solid preparation intermediate. Mix the intermediate with 100g of dextrin and 2g of aspartame, and fill it into 1000 bags (bags).

Embodiment 2

[0117] Weigh 12.5 g of methoxyphenamine hydrochloride, 7 g of narcotine, 25 g of aminophylline, and 1 g of ketotifen fumarate to prepare tablets according to the following method.

[0118] Weigh 7 g of auxiliary materials microcrystalline cellulose, 200 g of calcium hydrogen phosphate, 150 g of sodium carboxymethyl starch, 8 g of micropowder silica gel, 1 g of magnesium stearate, and an appropriate amount of coating auxiliary materials. The raw and auxiliary materials are respectively crushed through a 100-mesh sieve, and set aside. Mix 1 g of ketotifen fumarate and 7 g of microcrystalline cellulose in equal increments, add 7 g of narcotin and mix evenly, add 12.5 g of methoxyphenamine hydrochloride and mix evenly, then add 25 g of aminophylline and mix evenly, The compound oral solid preparation intermediate is obtained. Mix the intermediate with 150g sodium methyl starch and 8g micropowder silica gel, add 80% ethanol to make soft material, granulate with 24 mesh sieve, bake...

Embodiment 3

[0120] Weigh 12.5g of methoxyphenamine hydrochloride, 7g of narcotine, 25g of aminophylline, and 1g of ketotifen fumarate to prepare capsules according to the following method.

[0121] Take by weighing auxiliary materials dry starch 7g, medicinal calcium carbonate 50g, microcrystalline cellulose 190g, micropowder silica gel 10g, carboxymethyl starch sodium 60g auxiliary materials. The raw and auxiliary materials are respectively crushed through a 100-mesh sieve, and set aside. Mix 1 g of ketotifen fumarate and 7 g of dry starch in equal increments, add 7 g of narcotin and mix evenly, add 12.5 g of methoxyphenamine hydrochloride and mix evenly, then add 25 g of aminophylline and mix evenly to obtain Compound oral solid preparation intermediate. Mix the intermediate with 50g of calcium carbonate, 190g of microcrystalline cellulose, and 60g of sodium carboxymethyl starch, add 80% ethanol to make a soft material, granulate with a 30-mesh sieve, bake at 60-65°C for 2 hours, until...

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PUM

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Abstract

The invention relates to a formula of a compound medicine preparation for relieving cough and preventing asthma and a preparation method thereof. The formula mainly comprises the following components in parts by weight: 5-25 parts of methoxyphenamine hydrochloride, 3-15 parts of narcotine, 10-50 parts of aminophylline, 0.1-2 parts of ketotifen fumarate, and an appropriate amount of pharmaceutically acceptable auxiliary materials. In the invention, the methoxyphenamine hydrochloride, the narcotine, the aminophylline and the ketotifen fumarate are prepared into the compound medicine preparation for the first time; and the obtained compound medicine preparation has more obvious treatment effect on diseases such as cough, asthma, bronchial asthma, asthmatic bronchitis and the like; combination of the ketotifen fumarate and the aminophylline in the formula can enhance the bronchiectasis action of the aminophylline; and the mild sedation of the ketotifen fumarate can simultaneously counteract the central nervous system stimulation action caused by the aminophylline.

Description

technical field [0001] The invention relates to a compound pharmaceutical preparation with methoxyphenamine hydrochloride, narcotine, aminophylline and ketotifen fumarate as main active ingredients and a preparation method thereof. Specifically, a new compound pharmaceutical preparation and a preparation method thereof are prepared by using methoxyphenamine hydrochloride, narcotine, aminophylline, and ketotifen fumarate as main raw materials and pharmaceutically acceptable auxiliary materials. The compound medicine is mainly used for the treatment of cough, asthma, bronchial asthma and asthmatic bronchitis, and belongs to the technical field of new drug compound preparation medicine. Background technique [0002] As we all know, coughing is a protective respiratory reflex action of the human body. Cough occurs because when foreign bodies, irritating gases, respiratory secretions, etc. stimulate the receptors in the respiratory mucosa, the impulse is transmitted to the medul...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/4741A61K31/4535A61K31/137A61P11/14A61P11/06
Inventor 朱斌随裕敏郭凌云涂泽求时小燕
Owner 岳阳新华达制药有限公司
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