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Preparation method of methyl anthranilate

A technology of methyl anthranilate and methyl anthranilate, which is applied in the field of synthesis of organic compounds, can solve the problems of low content of methyl anthranilate, environmental pollution, waste water generation, etc., and achieve high yield and high content High, good appearance effect

Active Publication Date: 2014-06-18
濮阳市佳华化工有限公司
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Problems solved by technology

At present, the methods for industrial synthesis of methyl anthranilate include o-nitrobenzoic acid reductive esterification and using o-nitrobenzoic acid as a raw material to synthesize methyl o-nitrobenzoate through esterification, and then in Raney nickel Catalytic hydrogenation in the presence of methyl anthranilate, the content of methyl anthranilate obtained by these two methods is low, the yield is low, and waste water is generated in the production process, polluting the environment

Method used

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Embodiment Construction

[0015] The preparation method of methyl anthranilate comprises the following steps:

[0016] (1) 25% ammoniacal liquor of 937kg10 ℃ is put into amidation reactor, 1000kg phthalic anhydride is dropped in the amidation reactor, and ammoniacal liquor and phthalic anhydride react in the environment below 30 ℃ to generate o-formamide benzoic acid ammonium, react Time 2.5h. The 25% ammoniacal liquor that actually participates in the amidation reaction is 892.3kg, and 937kg of 25% ammoniacal liquor is added for the amidation reaction to be more complete.

[0017] (2) After the amidation reaction, put into the sodium hydroxide solution of 879kg30% in the amidation reactor, o-formamide benzoic acid ammonium and sodium hydroxide generation displacement reaction generate sodium o-formamide benzoate, then the amidation reactor The temperature inside rises to 50°C, and the ammonia molecules in the mixed solution are evaporated, and the evaporated ammonia gas is led by the induced draft fa...

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Abstract

The invention relates to the synthesis method of an organic compound, in particular to a preparation method of methyl anthranilate. The preparation method comprises the following steps: firstly using phthalic anhydride and ammonia water as raw materials to perform an amidation reaction and generate ammonium phthalamate; secondly adding sodium hydroxide solution to perform a displacement reaction and generate sodium phthalamate, removing ammonia molecules in the reaction solution, then adding methanol solution and sodium hypochlorite solution in the reaction solution to react and obtain paste methyl anthranilate, heating the paste methyl anthranilate to dissolve in water; and finally distilling the mixed liquid of methyl anthranilate and water to obtain methyl anthranilate. The methyl anthranilate prepared by the method of the invention has high content which is up to 98.4%; the appearance is good, the light transmittance of the product is 58.6%; the yield is high, which is increased by 0.4%-0.5% compared with the original technology; and the technology is advanced, the secondary recovery of ammonia water and methanol can be performed, and three wastes are not discharged in the production process.

Description

technical field [0001] The invention relates to a method for synthesizing organic compounds, in particular to a method for preparing methyl anthranilate. Background technique [0002] Methyl anthranilate is one of edible spices. It is mostly used as a raw material for flavoring. It is widely found in natural spice plants, especially in jasmine oil, orange leaf oil, and grapes planted in cold regions. With the increase of human demand for edible flavors, seeking industrial synthetic flavors has become one of the main development directions of modern fine chemical industry. At present, the methods for industrial synthesis of methyl anthranilate include o-nitrobenzoic acid reductive esterification and using o-nitrobenzoic acid as a raw material to synthesize methyl o-nitrobenzoate through esterification, and then in Raney nickel Methyl anthranilate is obtained by catalytic hydrogenation in the presence of the two methods. The content of methyl anthranilate obtained by these tw...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/56C07C227/18C07C227/20C07C227/40
Inventor 王传明游建岭高连甲
Owner 濮阳市佳华化工有限公司
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