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Method for preparing HCV (Hepatitis C Virus) inhibitor

A technology of inhibitor and reduction method, which is used in pharmaceutical formulations, antiviral agents, and medical preparations containing active ingredients, etc., can solve the problems of complex process, long operation time, unsuitable for industrial production, etc., and achieves simple and easy operation. to obtain the effect of price, mild reaction conditions

Inactive Publication Date: 2010-12-22
中国中化股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, its preparation method has the disadvantages of complex process, long operation time and unsuitability for industrial production.

Method used

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  • Method for preparing HCV (Hepatitis C Virus) inhibitor
  • Method for preparing HCV (Hepatitis C Virus) inhibitor
  • Method for preparing HCV (Hepatitis C Virus) inhibitor

Examples

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Abstract

The invention discloses a method for preparing an HCV (Hepatitis C Virus) inhibitor. The method comprises the following steps of: (1) obtaining a compound of a formula (6) through diazotizing, hydrolyzing, etherifying, reducing and acylating by using a 3-nitroaniline compound as a raw material; (2) providing a compound of a formula (10); (3) condensing and cyclizing the compound of the formula (10) and the compound of the formula (6) to prepare a compound of a formula (12); and etherifying and cyclizing the compound of the formula (12) and a compound of a formula (13) to obtain an HCV inhibitor of a formula A. The method has the advantages of easy raw material obtaining, low price, moderate reaction condition, simple operation and easy industrialization.

Description

technical field The invention relates to the field of medicine, in particular, the invention relates to a method for preparing HCV inhibitors. Background technique Hepatitis C virus (HCV) is the major etiological agent of posttransfusion and socially acquired non-A non-B hepatitis worldwide. It is estimated that there are currently 170 million virus carriers or patients in the world. Patent documents WO00 / 059929, WO2007 / 014919, WO2007 / 014926, WO2008 / 092954, WO2008 / 092955, WO2008 / 096002, WO2009 / 005676, WO2009 / 014730 disclose various types of NS3 serine protease inhibitors as hepatitis C virus Peptides and / or other compounds and methods for their preparation. Wherein described has the macrocyclic peptide compound that can inhibit hepatitis C virus activity, this class compound can specifically inhibit the NS3 protease of hepatitis C virus, and to other serine proteases (such as human leukocyte elastase (HLE), The fact that porcine pancreatic elastase (PPE) or bovine pancrea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D417/14A61K31/4709A61P31/14
Inventor 林邦平李斌赵海杜晓栋杨建军
Owner 中国中化股份有限公司
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