Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal preparation for treating phthisis

A drug preparation and tuberculosis technology, applied in the field of medicine, can solve problems such as multi-drug resistance and tuberculosis resistance

Inactive Publication Date: 2010-12-01
北京卓越同舟药物研究院有限公司
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, causing tuberculosis drug resistance or even multidrug resistance, making patients refractory cases is one of the important reasons for the resurgence of tuberculosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal preparation for treating phthisis
  • Medicinal preparation for treating phthisis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 is to the effect of Mycobacterium tuberculosis in vivo

[0015] Effects on Mycobacterium tuberculosis in the body Take Kunming mice, divide them into groups, and take the human Mycobacterium tuberculosis H37RV culture grown on the modified Roche medium for two weeks to make a uniform bacterial suspension of 5 mg / ml, and give each mouse Rats were injected with 0.2ml into the tail vein, and the administration was started on the next day after infection, and administered once a day, until half of the blank control group died, and the death time of the mice was recorded. The survival time of half of the animals (STS.) was Indicators, the results are shown in Table 1.

[0016] Table 1 The median survival time of animals in each group

[0017]

Embodiment 2

[0018] Example 2 The effect of phytohemagglutinin on lymphocyte transformation. Male mice were randomly divided into groups, control group, positive drug group, and drug group of the present invention, and were administered by intragastric administration for 10 days. From the 6th day of administration, each mouse had Phytohemagglutinin 10mg / kg was injected intramuscularly every day for a total of 4 days. On the 10th day of administration, the tail was cut to take blood and push the slices, stained with Giemsa, counted 100 lymphocytes, lymphoblasts and transition cells under the oil microscope, and calculated them The respective percentages are shown in Table 2.

[0019] Table 2 Effects on the transformed reaction of mouse lymphocytes

[0020]

[0021] Note: Compared with the control group, **P<0.01.

Embodiment 3

[0022] Example 3 Effects on Delayed Hypersensitivity

[0023] Get the mice, divide them into at random, and continuously gavage the medicine for 10 days. On the 4th day of administration, 1% 2,4-dinitrochlorobenzene 50ml is evenly applied to the abdominal hair removal site. On the 9th day of administration, the 10ml of 1% 2,4-dinitrochlorobenzene was evenly applied to the right ear of the mice for challenge. After 24 hours after the challenge, they were killed.

[0024] group

Weight difference between two ears (mg)

control group

4.1±1.7

gecko treatment tuberculosis pill

3.5±1.3*

Pharmaceutical preparation of the present invention

1.6±0.4**

[0025] Note: Compared with the control group, **P<0.01; *P<0.05.

[0026] Preparation Example

[0027] Example 1

[0028] Psoralen B 1g, Danshensu sodium 1g.

[0029] The above-mentioned crude drug is prepared into 1000 tablets or 1000 capsules.

[0030] Example 2

[0031]...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a medicinal preparation for treating phthisis, which is characterized by comprising the following raw material medicaments in part by weight: 1 to 100 parts of corylifolinin and 1 to 100 parts of salvianic acid A sodium. Pharmacological tests show that the medicinal preparation has good effect of treating phthisis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation containing psoralen B and danshensu sodium. technical background [0002] Tuberculosis, also known as tuberculosis, is an infectious disease since ancient times, and has become the number one infectious disease in the world in recent years. In history, it was widely popular all over the world and was once the main killer against human beings, taking hundreds of millions of lives. Tuberculosis is also the main disease that causes poverty due to illness and returns to poverty due to illness. Tuberculosis is also a zoonotic infectious disease. Tuberculosis is not only a public health problem, but also a socioeconomic one. Control is a long way to go. As long as the government pays attention to it, increases investment, implements modern and scientific control strategies, and fights against it continuously for a long time, tuberculosis is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K31/12A61K9/20A61P31/06A61P11/00
Inventor 王爱民安晓雪
Owner 北京卓越同舟药物研究院有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com