Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit

A detection tool and technology for premature rupture of membranes, applied in measuring devices, instruments, disease diagnosis, etc., can solve problems such as detection tools for premature rupture of membranes that have not yet been found, and achieve industrial production, improved detection speed, and easy processing and production Effect

Inactive Publication Date: 2010-10-27
ORIGISSAY BIOLOGICS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although in the third trimester of pregnancy (gestational weeks 28-40), ICAM-1 levels in amniotic fluid of pregnant women increase due to the expression of ICAM-1 on monocytes in the fetal membranes and amniotic fluid and the activation of neutrophils, but currently There are no reports of premature rupture of membranes detection tool using ICAM-1 as the detection index

Method used

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  • Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit
  • Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit
  • Premature rupture of membrane fast examination tool using ICAM-1 as examination index and examination kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] In this embodiment, the rapid detection tool for premature rupture of membranes with ICAM-1 as the detection index is as follows: figure 1 , figure 2 As shown, its shape is a rectangular strip, and its structure includes a liner 1, an absorbent pad 2, a nitrocellulose membrane 5, a gold standard pad 6, and a sample pad 7, and the absorbent pad, nitrocellulose membrane, gold standard pad, and sample The pads are pasted on the liner sequentially from top to bottom, and the gold standard pad is partially covered by the sample pad. Liner 1 is made of medical plastic high-whiteness PVC sheet, coated with pressure-sensitive adhesive, which is inert to biologically active molecules; water-absorbing pad 2 is made of water-absorbing paper; 1 The detection line 4 formed by polyclonal antibody coating and the control line 3 formed by the goat anti-mouse IgG polyclonal antibody coating, the detection line 4 is located below the control line 3, and their width is 1mm (or 0.8mm or ...

Embodiment 2

[0053] In this embodiment, the shape and structure of the premature rupture of membranes rapid detection box with ICAM-1 as the detection index are as follows: Figure 6 As shown, it is composed of a box body 8 and a detection tool 12 loaded into the box body. The detection tool 12 is the detection tool with the shape and structure described in Embodiment 1. Described box body 8 is made of medical plastics, as image 3 , Figure 4 , Figure 5 As shown, the shape is a cuboid, and the inner cavity matches the shape and size of the detection tool. Its top wall is provided with a detection tool insertion hole 11, and its side wall is provided with a sample injection hole 10 and an observation hole 9. The sample injection hole 10 The setting position of the detection tool corresponds to the position of the sample pad 7 after the detection tool is loaded into the box body, and the setting position of the observation hole 9 corresponds to the position of the detection line 4 and t...

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Abstract

The invention discloses a premature rupture of membrane (PROM) fast examination tool using an intercellular adhesion molecular (ICAM)-1 as an examination index. The tool comprises a gasket, an absorbent pad, a nitrocellulose membrane, a conjugate pad and a sample pad, wherein the absorbent pad, the nitrocellulose membrane, the conjugate pad and the sample pad are connected from top to bottom and adhered to the gasket; the conjugate pad is covered by the sample pad part; the nitrocellulose membrane is provided with a goat-anti-human ICAM-1 polyclonal antibody coated examination line and a goat-anti-mouse immunoglobulin G polyclonal antibody coated control line; the examination line is below and away from the control line at intervals; and the conjugate pad is a water absorbing fibber coated with conjugated mouse-anti-human ICAM-1 monoclonal antibody conjugate. A PROM fast examination kit using the ICAM-1 as the examination index consists of a kit body and the examination tool arranged in the kit body.

Description

technical field [0001] The invention belongs to medical detection tools, in particular to a detection tool for detecting premature rupture of membranes (Premature Rupture of Fetal Membrane, PROM for short) in pregnant women. Background technique [0002] Rupture of Fetal Membrane (ROM) may occur at any time during pregnancy, and rupture of fetal membranes before labor is called premature rupture of membranes (PROM). The incidence of PROM after term (37 weeks of pregnancy) is about 10%; the incidence of PROM before term (before 37 weeks of pregnancy) is 2-3.5%. Premature rupture of membranes is the main factor causing prenatal and postpartum complications in obstetric patients, and the main reason for premature birth and neonatal admission to the intensive care unit. Because medical personnel have to balance the prolongation of gestational weeks with the risk of intrauterine and maternal infection and fetal lung development problems, the management of patients with premature...

Claims

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Application Information

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IPC IPC(8): G01N33/577G01N33/558G01N33/531
CPCG01N2333/70525G01N2800/368G01N33/689
Inventor 胡怀忠关祥乾向洪发周容
Owner ORIGISSAY BIOLOGICS TECH
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