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Application of nordihydroguaiaretic acid in preparing drug capable of resisting tumour stem cells

A technology of dihydroguaiaretic acid and glioma stem cells, which is applied in the directions of anti-tumor drugs, drug combinations, active ingredients of hydroxyl compounds, etc., to achieve the effect of improving the effect of tumor treatment and improving the quality of life

Inactive Publication Date: 2010-10-27
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, whether NDGA has an anti-CSC effect has not been reported

Method used

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  • Application of nordihydroguaiaretic acid in preparing drug capable of resisting tumour stem cells
  • Application of nordihydroguaiaretic acid in preparing drug capable of resisting tumour stem cells
  • Application of nordihydroguaiaretic acid in preparing drug capable of resisting tumour stem cells

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Experimental program
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Embodiment Construction

[0036] The anti-CSC effect of NDGA will be described in detail below with reference to the accompanying drawings.

[0037] Experimental materials and instruments: For the preparation method of Nordy, refer to the literature (Bian XW, et al. Proteomics, 2008, 8(3): 484-494) and the Chinese patent application with application number 02133700.4; gastric cancer cell SGC7901, liver cancer cell Hu-7, Colon cancer cell HCT116, breast cancer cell MCF-7, lung cancer cell A549 and glioma cell U87 were purchased from American Type Culture Collection (ATCC); rabbit anti-human ALOX-5 polyclonal antibody was purchased from Santa Cruz Company, rabbit Anti-human GFAP polyclonal antibody was purchased from Zymed Company, mouse anti-human nestin polyclonal antibody was purchased from Chemicon Company, mouse anti-human CD133 polyclonal antibody was purchased from Abcom Company, and PE-labeled mouse anti-human CD133 antibody was purchased from Miltenyi Biotec Company , the mouse anti-human Ki-67 ...

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Abstract

The invention relates to a new application of compound, in particular to the application of nordihydroguaiaretic acid in preparing drug capable of resisting tumour stem cells. The nordihydroguaiaretic acid inhibits the activity of arachidonic acid-5-lipoxidase to prevent glioma stem cells from breeding and induce the glioma stem cells to differentiate to astrocyte phenotype; the nordihydroguaiaretic acid has better in vivo curative effect on glioma than the classical glioma chemotherapeutics, i.e. carmustine; meanwhile, the nordihydroguaiaretic acid can obviously inhibit tumour stem cells of gastric cancer, liver cancer, lung cancer, colon cancer, breast cancer and the like from breeding.

Description

technical field [0001] The present invention relates to a new application of compounds, in particular to the application of nordihydroguaiaretic acid (abbreviated as NDGA) in the preparation of drugs against tumor stem cells (abbreviated as CSC). Background technique [0002] In recent years, studies have found that the occurrence and progression of malignant tumors depend on a small group of tumor cells with self-renewal and multidirectional differentiation capabilities, that is, the CSC subset, and most other tumor cells are differentiated from this small group of cells and are It leads to the heterogeneity of tumor tissue in morphology and function, and CSC is the source and initiator of tumorigenesis. This finding has important implications for the development of new and more effective anti-tumor treatments. Although the anti-tumor treatment scheme lacking CSC targeting can kill a large number of differentiated tumor cells (non-CSC for short) in a short period of time a...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P35/00
Inventor 王斌卞修武平轶芳余时沧
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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