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Nitrogen-containing heterocyclic thienopyridine compounds and preparation method and application thereof

A compound, pyridine technology, applied in the field of medicine, can solve the problems of low specificity, toxic side effects, poor selectivity, etc.

Inactive Publication Date: 2010-09-29
TIANJIN INSTITUTE OF PHARMA RESEARCH
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Problems solved by technology

Traditional chemotherapeutic drugs have obvious clinical therapeutic effects, but their disadvantages are: low specificity and poor selectivity, leading to obvious toxic and side effects, and prone to serious tumor multi-drug resistance, which limits clinical application. Looking for safe and effective anti-tumor drugs Drugs have always been the pursuit of the pharmaceutical industry

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  • Nitrogen-containing heterocyclic thienopyridine compounds and preparation method and application thereof
  • Nitrogen-containing heterocyclic thienopyridine compounds and preparation method and application thereof
  • Nitrogen-containing heterocyclic thienopyridine compounds and preparation method and application thereof

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Abstract

The invention belongs to the technical field of drugs for resisting malignant tumor and provides nitrogen-containing heterocyclic thienopyridine compounds with the structure shown as a general formula I and salts thereof, wherein R1 is hydrogen, and C1-C4 are alkanoyloxy substituted by alkyl; and R2 is nitrogen-containing six-membered heterocycle, i.e. benzoazo six-membered heterocycle. The invention further relates to a method for preparing the compounds, and also discloses drug compositions taking the compounds or the salts thereof as the active effective components and application thereof as drugs for resisting malignant tumor.

Description

technical field The invention belongs to the technical field of medicine, more specifically, relates to a class of compounds with anti-malignant tumor effects and a preparation method thereof. Background technique Tumor is a common disease that threatens human life. According to statistics, the total number of cancer deaths in the world reaches 7 million people every year. In my country, more than 1 million people die from cancer every year, and gradually increase. It has become the first cause of death in urban population. Traditional chemotherapeutic drugs have obvious clinical therapeutic effects, but their disadvantages are: low specificity and poor selectivity, leading to obvious toxic and side effects, and prone to serious tumor multi-drug resistance, which limits clinical application. Looking for safe and effective anti-tumor drugs Drugs have always been the pursuit of the pharmaceutical industry. Contents of the invention One object of the present invention is to...

Claims

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Application Information

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IPC IPC(8): C07D495/04A61K31/4709A61K31/444A61P35/00A61P35/02
Inventor 刘登科刘颖刘默刘冰妮周云松祁浩飞侯佳佳王平保
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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