Silica gel particle surface artemisinin molecularly imprinted polymer and preparation and application method thereof

Abstract

The invention relates to a silica gel particle surface artemisinin molecularly imprinted polymer which is obtained by taking artemisinin as template molecules, adopting functional silica gel particles which are as shown in the formula (1) and the silica gel particles (CABS) with the surface modified by calix (4) arene, monomeric compounds as shown in the formula (2) and the monomeric compounds as shown in the formula (3) for carrying out random copolymerization, obtaining the polymer, and then removing the artemisinin in the polymer. The invention further provides a preparation method and an application method of the silica gel particle surface artemisinin molecularly imprinted polymer, the silica gel particle surface artemisinin molecularly imprinted polymer can separate the artemisinin from structural analogues of artemether and the like under the conditions of normal temperature and normal pressure and the supercritical conditions, thereby being particularly applicable to the supercritical conditions and having specific absorption, selectivity and good mechanical stability; and the preparation method is simple and convenient, and applicable to large-scale popularization.

Description

technical field The invention relates to the technical field of molecularly imprinted polymers, in particular to the technical field of artemisinin molecularly imprinted polymers, in particular to an artemisinin molecularly imprinted polymer on the surface of silica gel particles and its preparation and application method, especially suitable for supercritical conditions Separation and purification of artemisinin. Background technique Artemisinin (artemisinin, AR) is a colorless needle-like crystal. It is an active antimalarial ingredient extracted from the plant Artemisia annua. drug. However, since the content of artemisinin in the original plant Artemisia annua is very low, generally only about 0.7%, it is difficult to meet the needs of clinical research and use. Therefore, it is of great economic and social significance to find effective ways to produce artemisinin. Generally speaking, the current sources of artemisinin are: (1) direct extraction from the plant Artemi...

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Problems solved by technology

Molecularly imprinted polymers have problems such as slow mass transfer rate, difficulty for imprinted molecules to reach th...

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