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Anti-coagulation composite ultrafiltration membrane and preparation method thereof

An ultrafiltration membrane and anti-coagulation technology, which is applied in the field of anti-coagulation composite ultrafiltration membrane and its preparation, can solve the problems of limited source of raw materials, high price, complex process, etc., and achieve stable physical and chemical properties, low cost, and preparation equipment simple effect

Inactive Publication Date: 2012-07-04
江苏朗生生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Heparin is mainly extracted and refined from the liver, lung, heart, spleen and other internal organs of mammals. Not only is it expensive, the process is complicated, and the source of raw materials is limited, but it also has side effects of bleeding tendency in animals.

Method used

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  • Anti-coagulation composite ultrafiltration membrane and preparation method thereof
  • Anti-coagulation composite ultrafiltration membrane and preparation method thereof
  • Anti-coagulation composite ultrafiltration membrane and preparation method thereof

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Embodiment Construction

[0021] See figure 1 As shown, the anticoagulant composite ultrafiltration membrane of the present invention comprises a support layer, a polysulfone-based membrane layer and a sulfonated chitosan membrane layer, the polysulfone-based membrane layer is attached to the support layer, and the sulfonated chitosan membrane layer The cross-linking is grafted on the polysulfone-based membrane layer, the thickness of the support layer, the polysulfone-based membrane layer and the sulfonated chitosan membrane layer is 30-100 microns, and the thickness of the sulfonated chitosan membrane layer is 0.01-0.5 Between microns, the viscosity-average molecular weight of this sulfonated chitosan film layer is 30000-300000, and the supporting layer of the present invention is non-woven fabric, or adopts 200-300 mesh screen, and this anticoagulant composite ultrafiltration membrane has good bioactivity, hemocompatibility and anticoagulant properties.

[0022] Sulfonated chitosan of the present i...

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Abstract

The invention relates to an anti-coagulation composite ultrafiltration membrane, which comprises a supporting layer, a polysulfone-based membrane layer and a sulfonated chitosan membrane layer, wherein the thicknesses of the supporting layer, the polysulfone-based membrane layer and the sulfonated chitosan membrane layer range from 30 to 100 micrometers; the thickness of the sulfonated chitosan membrane layer is between 0.01 and 0.5 micrometer, and the viscosity-average molecular weight of the sulfonated chitosan membrane layer is 30,000 to 300,000. The anti-coagulation composite ultrafiltration membrane of the invention is improved in membrane surface performance, hydrophily, mechanical strength and anti-coagulation performance, has high bioactivity, blood compatibility and anti-coagulation performance and uses a greatly reduced amount of or no heparin in a blood purification process. The membrane preparation process is simple and can realize industrial production.

Description

technical field [0001] The invention relates to an anticoagulant composite ultrafiltration membrane and a preparation method thereof, belonging to the technical field of polymer membranes. Background technique [0002] Polysulfone is an engineering material with superior performance that has been artificially synthesized in recent years. It has good biocompatibility, excellent mechanical properties, heat resistance, alkali resistance, corrosion resistance, etc., and is cheap. It is currently the most commonly used One of the membrane materials, the prepared membrane is widely used in blood purification treatment. However, since polysulfone is a strongly hydrophobic material, in order to improve the hydrophilic properties of polysulfone membranes, it is usually used to add hydrophilic properties such as polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), polyethylene glycol (PEG) at home and abroad. Material. The addition of hydrophilic materials such as polyvinylpyrrolido...

Claims

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Application Information

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IPC IPC(8): B01D71/68B01D69/10B01D69/12
Inventor 戈旭亚唐勇红
Owner 江苏朗生生命科技有限公司
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