Process for extracting astragaloside IV

An extraction process, astragaloside IV technology, applied in the directions of steroids, organic chemistry, etc., can solve problems such as unfavorable popularization of production, low product yield, need special equipment and technology, etc., and achieves improved yield, good effect, pollution, etc. small effect

Inactive Publication Date: 2010-06-02
张守力
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] An object of the present invention is to provide a simple and effective product with high product yield and the ability to realize large-scale and industrialized production in order to so...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Select 1 kg of Astragalus rhizome slices, add 2 times of water, add enzymes, and carry out enzymatic hydrolysis. The extraction process is divided into 2 times. The first time is extracted with 12 times the quality of Astragalus with deionized water for 4 days; the second time, the amount of water added is 10 Times, Extract 3d. The water extract was filtered and concentrated with filter paper, 3 times the volume of the concentrated solution was added with 95% ethanol, allowed to stand for 24 hours, the precipitate was removed by filtration, the filtrate was concentrated, and the ethanol was recovered.

[0020] Extraction: extract and degrease the obtained astragalus total saponins concentrated solution with 1 / 3 volume of petroleum ether for 3 times, extract for 3 hours each time, combine the lower layer solution, and repeat the extraction with 1 / 3 of the volume of the degreased concentrated solution with water-saturated n-butanol for 3 times times, each extraction was 2...

Embodiment 2

[0025] Select 1 kg of Astragalus rhizome slices, add 5 times of water, add enzymes, and carry out enzymatic hydrolysis. The extraction process is divided into 3 times. The first time is extracted with deionized water with 8 times the quality of Astragalus for 4 days; times, extract 3d, and extract 4h with 6 times water for the third time. The water extract was filtered and concentrated with filter paper, 98% ethanol was added with 2 times the volume of the concentrated solution, allowed to stand for 20 hours, the precipitate was removed by filtration, the filtrate was concentrated, and the ethanol was recovered.

[0026] Extraction: extract and degrease the obtained astragalus total saponins concentrated solution with 1 / 2 volume of petroleum ether for 3 times, extract 3 hours each time, combine the lower layer solution, and then repeat the extraction with 1 / 2 volume of the degreased concentrated solution with water-saturated n-butanol for 3 times times, each extraction was 2h,...

Embodiment 3-11

[0030] Based on 10kg raw material, the consumption and composition of enzyme, and enzymolysis time and temperature are shown in the table below, and all the other are with embodiment 1:

[0031]

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PUM

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Abstract

The invention relates to the field of medicament extraction and refining, which is a process for extracting astragaloside IV and solves the problems that the products of the prior art has low yield or needs special devices and technology, is not beneficial to generalization and production and the like. The invention provides a simple, effective, high-yield and new extracting process capable of realizing the industrial large-scale production. The process is operated by the following steps of: cutting raw materials in to pieces or coarse grains, adding enzyme for enzymolysis, and after the enzymolysis, extracting the raw materials by water; extracting and refilling the astragaloside IV. The invention combines the enzymolysis method with a water extraction method and an ethanol extraction method, such that the astragaloside IV in the raw materials can be extracted in maximum; the waste of the raw materials is avoided, the production rate of the astragaloside IV is improved, and the yieldof the astragaloside IV is high. In addition, a solution mixing butyl acetate and tert-butyle alcohol is used for refilling, such that the finally obtained product has good quality, stable formation and high yield; and the raw materials are repeatedly and fully utilized in the whole production process, thus the economic efficiency is improved, the environment is protected, and the invention is suitable for the industrial production.

Description

technical field [0001] The invention relates to the field of medicine extraction, and relates to an extraction process of astragaloside IV. Background technique [0002] Astragalus It has the functions of invigorating the middle qi, nourishing blood and promoting blood circulation, diuresis and detumescence, solidifying the surface and antiperspirant, etc. It mainly contains triterpenoid saponins, flavonoids and polysaccharides. Among the triterpenoid saponins, astragaloside I (also known as astragaloside IV) and II are the main ingredients. The main components, especially astragaloside IV, are often used as the main indicators for quality control. The extraction methods of astragaloside IV mainly include water decoction, ethanol reflux extraction, ultrasonic extraction, CO 2 Supercritical extraction method. The ethanol reflux extraction method consumes a lot of alcohol and requires a complete set of reflux equipment. Although the medicinal material of Astragalus membra...

Claims

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Application Information

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IPC IPC(8): C07J53/00
Inventor 张守力
Owner 张守力
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