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Combined medicine containing metformin hydrochloride and vitamin B12

A technology of metformin hydrochloride and metformin acid, applied in the field of medicine, can solve the problems affecting the quality of life of patients, the long-term survival rate of aplastic anemia is less than 30%, etc., and achieve the effects of preventing diabetic macrovascular disease, reducing medical expenses, and being cheap.

Active Publication Date: 2010-06-02
北京博为高科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term survival of stem cell transplantation from unrelated donors for aplastic anemia is less than 30%
Androgen drugs have severe liver toxicity, drug-induced liver damage occurs in almost every patient, and female patients will appear masculine characteristics, seriously affecting the quality of life of patients

Method used

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Embodiment Construction

[0037] The present invention will be further clarified through the detailed description of specific embodiments below, but it is not intended to limit the present invention, but only for illustration.

[0038] In the present embodiment, for patients with aplastic anemia, 250 mg of metformin hydrochloride and 250 μg of vitamin B12 (calculated as adenosylcobalamin or methylcobalamin or cyanocobalamin) in each tablet of the combination medicine of the present invention are taken orally, 3 times / day. Adjust the dose and medication time according to the condition. For diabetic patients, the composition that can be used is a standard dose of metformin hydrochloride (250 mg) + lower than therapeutic dose of vitamin B12 (<250 ug) for treatment. The following is the clinical data:

[0039] Thirty-three patients with aplastic anemia were treated with metformin hydrochloride combined with vitamin B12, all of them were patients with chronic aplastic anemia, including 19 males and 14 fe...

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PUM

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Abstract

The invention provides a combined medicine containing metformin hydrochloride and vitamin B12, which can prevent and treat diabetic peripheral neuropathy to the maximal extent, prevent metformin hydrochloride from inducing hyperhomocysteinemia, malabsorption of vitamin B12 to cause megaloblastic anemia, and treat aplastic anemia and the like.

Description

technical field [0001] The invention relates to a combination medicine containing metformin hydrochloride and vitamin B12, which belongs to the field of medicine. Background technique [0002] Metformin is mainly known for its anti-hyperglycemic activity. Metformin hydrochloride is widely used in non-insulin-dependent diabetes mellitus. It is widely used in clinical practice and has a clear hypoglycemic effect. By reducing absorption, promoting peripheral tissue to increase sugar utilization and reducing insulin resistance and other ways to play a role in lowering blood sugar. Compared with insulin and other kinds of hypoglycemic drugs, metformin hydrochloride is cheap and can be produced by many domestic pharmaceutical units without patent restrictions. It is currently the most widely used hypoglycemic drug in clinical practice. [0003] Metformin hydrochloride has a wide range of clinical applications. Compared with other types of hypoglycemic drugs, the adverse reaction...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K31/155A61P3/10A61P7/06
Inventor 卢学春迟小华
Owner 北京博为高科生物科技有限公司
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