Method for granulating medicament for treating osteoporosis

Abstract

The invention relates to a method for granulating a medicament for treating osteoporosis, which comprises the following steps of: firstly uniformly mixing the medicament and auxiliary materials; adding a polymer blend, and stirring the mixture to obtain a soft material; preparing wet granules from obtained soft material with a granulator; placing the prepared wet granules into a boiling drier to dry; discharging the granules after drying the granules; passing the granules through a 25-mesh screen; mixing the granules; and encapsulating 0.45g of granules into each number 1 capsule to obtain a capsule preparation. The polymer blend has the functions of adhesion and coating, and ensure that the medicament fine powder is tightly prepared into balls and each ball is coated with a layer of film coating, so that powder granule gaps are reduced, the requirements of encapsulating materials into the number 1 empty capsule is met, the medicament only encapsulated by a large number 0 empty capsule can be successfully encapsulated by the small number 1 empty capsule, the volume of the finished capsule is decreased which is convenient for administration, the compliance of medication is increased, sale and use of the medicament are promoted, and good benefits for society and enterprises can be created.

Description

technical field [0001] The invention relates to capsule medicine, in particular to a granulation method of medicine for treating osteoporosis. Background technique [0002] Capsules are preparations that are filled with drugs in a hollow capsule shell that is tightly fitted by the capsule body and capsule cap. According to the capsule drug standard, hollow capsules have 8 sizes and specifications code-named No. 000, No. 00, No. 0, and No. 1 to No. 5, all of which are cylindrical. Among them, the specifications of No. 00 to No. 2 and the value of the capsule body volume are: No. 00, the volume is 0.95ml; No. 0, the volume is 0.68ml; No. 1, the volume is 0.50ml; No. 2, the volume is 0.37ml. That is, the larger the number of specifications, the smaller the volume of the bag body, that is, the less weight of the contents. [0003] The appropriate filling volume of No. 0 capsule is generally between 0.4 and 0.6 g, and the filling volume of No. 1 capsule is between 0.3 and 0.4 g...

AI Technical Summary

Problems solved by technology

[0007] The original capsule adopts the conventional granulation method, the prepared granules are irregular, the particle size distribution is uneven, the thickness ratio is uncontrollable, the granule fluidity is not good, the granule gap is large, and the bulk density is small. The maximum bulk density can only reach about 0.80g / ml, and the weight of the particles filled into the No. 1 capsule shell is less than 0.40g

Therefore, it is very difficult to change No. 0 empty capsules into No. 1 fillings for the osteoporosis drug Zhuangguzhitong capsules

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