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Medicinal composition for treating canker sore and local infection of body surface and reducing inflammation, product and application thereof

A technology for oral ulcers and local infection, which is applied in the directions of drug combinations, topical antibacterial agents, and medical preparations containing active ingredients, etc., can solve the problems of inability to relieve the pain of patients in time, inability to solve the pain of patients in time, and unsatisfactory effects, etc. The effect of promoting ulcer healing, reducing permeability and inhibiting metastasis

Inactive Publication Date: 2010-05-12
金日制药(中国)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The etiology of RAU is not yet fully understood, and it is difficult to cure it. Traditional treatment is often not effective. At present, drug treatment is still the first choice for clinical treatment of RAU. Therefore, it is very important to find a safer and more effective treatment.
In recent years, scholars at home and abroad believe that it is related to abnormal immune function, and advocate the use of levamisole, corticosteroids, placental globulin or gamma globulin, interstitial fluid, and vaccinia scratch vaccination for treatment. The above drugs have certain effects, but the course of treatment is relatively long. long, can not solve the patient's pain in time, and promote ulcer healing
There are also glucocorticoids that are used alone, such as dexamethasone acetate to make pastes, but they can only be used for non-infected oral mucosal ulcers. Generally, the use of glucocorticoids will aggravate the condition after infection, and cannot relieve the patient's pain in time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Gentamicin sulfate, tetracaine hydrochloride and dexamethasone acetate are mixed in a weight ratio of 2:4:0.5 and mixed with matrix carrier to make a film for clinical treatment, as shown in the following table:

[0015] Table 1 embodiment 1 treatment effect table

[0016] diagnosis

markedly effective

efficient

invalid

Efficient

total effective rate

recurrent mouth ulcers

30

40

5

93.33％

94.23％

traumatic ulcer

10

12

1

95.65％

herpetic stomatitis

1

1

0

/

Lichen planus (erosive type)

1

1

0

/

chemical ulcer

0

1

0

/

scald

1

0

0

/

[0017] Typical cases:

[0018] (1) The patient, Ms. Yang, 44 years old, a cadre, suffered from recurrent oral ulcers for five years. In the past two years, the attacks have been frequent, with almost no gap period, and the occasi...

Embodiment 2

[0025] Add sisomycin, lidocaine and cortisone in a ratio of 0.1:2:0.05 by weight to add film materials (polyvinylpyrrolidone, povidone, sodium carboxymethyl cellulose, polyvinyl alcohol, polyvinyl alcohol, etc.) Acetaldehyde, etc.), moisturizers, antioxidants, ethanol, water, etc. are made into film-coating agents for clinical treatment, as shown in the following table:

[0026] Table two embodiment two treatment effect tables

[0027] diagnosis

Embodiment 3

[0029] Add azithromycin, mepivacaine and hydrocortisone in a weight ratio of 4:5:1 plus propellant and excipient to make aerosol for clinical treatment, as shown in the following table:

[0030] Table three embodiment three treatment effect table

[0031] diagnosis

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PUM

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Abstract

The invention relates to a medicinal composition for treating canker sore and local infection of body surface and reducing inflammation, a product and application thereof. The medicinal composition comprises aminoglycoside antibiotics, local anaesthetics and glucocorticoids in weight ratio of (0.1-10):(1-10):(0.01-10). Compared with the prior art, the medicinal composition has the advantages that local anaesthetics can alleviate pains of patients in time; antibiotics has the antibiotic effect of treating infection caused by bacteria; and the glucocorticoids has the anti-inflammatory effect of reducing focus hyperemia, reducing permeability of capillary and inhibiting inflammatory cells from transferring to the inflammatory part; and the synergistic action of the three medicaments promotes the healing of canker sore so as to achieve good treatment effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating oral ulcer and local infection on the body surface and anti-inflammation, its preparation and application. Background technique [0002] Oral ulcer is one of the common complications of patients with blood diseases. Recurrent oral ulcer (RAU) is one of the most common oral mucosal diseases. The ulcer is round or oval, and can appear in any part of the mucosa. It can occur, has the characteristics of recurrent attacks and burning pain, and persists for a long time, seriously affecting the patient's diet and language ability. Although it is not life-threatening, it causes unspeakable suffering to the patient. The etiology of RAU is not yet fully understood, and it is difficult to cure it. Traditional treatments are often unsatisfactory. Currently, drug therapy is still the first choice for clinical treatment of RAU. Therefore, it is very important to find a safer and more effective treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P1/02A61P17/02A61P9/14A61P31/02
Inventor 张杰赖荣胜
Owner 金日制药(中国)有限公司
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