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High purity scutellarin salt bulk drug and preparation method thereof

A high-purity technology of scutellarin, which is applied in the field of raw materials to achieve cost-saving and environmental-friendly effects

Active Publication Date: 2010-03-31
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The bulk drug of scutellarin salt directly used in the preparation of injection preparations has not been reported yet

Method used

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  • High purity scutellarin salt bulk drug and preparation method thereof

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Embodiment 1

[0018] Weigh 500 g of commercially available scutellarin crude drug, add 5 times the weight of water, heat to 70° C., adjust the pH to 7.5 with 20% sodium bicarbonate solution to completely dissolve. The solution is centrifuged and precipitated at 16000r.p.m, and the obtained centrifugate is placed on an AB-8 macroporous resin column and eluted with water at a flow rate of 200-300ml / min. Add hydrochloric acid to 2ml of the eluate to acidify without turbidity), the collected eluate is concentrated at 70°C and the pressure is 0.05MPa to 4500ml under reduced pressure, add 5 times the volume of acetone, stir, precipitate, stand for 10 hours, and filter with suction , washed with acetone for 6 times, and dried at 65°C to obtain the bulk drug of scutellarin sodium with a purity as high as 99.75%.

[0019] Gained scutellarin sodium crude drug was analyzed and determined by high-performance liquid chromatography, and the data are as follows:

[0020] Instrument Type: Liquid Chromatog...

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Abstract

The invention relates to a new bulk drug in pharmaceuticals industry, and preparation process thereof. The bulk drug of the invention wherein has a weight percentage of more than 98% scutellarin salt.The preparation method is composed of following steps: first, using breviscapinun saled in market as raw materials, adding 5 to 10 times of water by weight, being heated to 60 to 80 DEG, adding 10 to20 weight percentage of aqueous slkali until the pH value is 5 to 8; second, centrifugating the solution obtained in the step one and discarding the deposition, then the obtained solution going through macroporous resin column, washing and removing, discarding the deep brown part of the first eluant, and then collecting the yellow eluant part; third, the collected eluant is disposed in vacuum concentrator, concentrating until concentration of the scutellarin salt solution is 100 to 200 mg / ml; fourth, adding organic solvent to the concentrated solution obtained in the step three and stirring,depositing, standing and filtering; fifth, washing by using the same organic solvent of the step four for 3 to 6 times, drain, and drying at a temperature of 60 to 80 DEG, then the bulk drug is obtained.

Description

technical field [0001] The invention relates to a new raw material drug in the pharmaceutical industry and a preparation process. Background technique: [0002] Erigeron breviscapus (Vant) H-M is an active ingredient of flavonoids isolated from the whole plant of Erigeron breviscapus (Vant) H-M. For 4',5,6-trihydroxyflavone-7-0-gluconoside. The commercially available scutellarin crude drug B content is about 85-90%. Its various preparations have been widely used clinically to treat cardiovascular and cerebrovascular diseases, and the curative effect is remarkable, but the stability of the injection is poor, and the storage time is short. , the occurrence of these phenomena is mainly due to the fact that some impurities are not removed during the production process of the raw material medicine. This problem has not been resolved since the advent of the scutellaria product for more than 30 years. [0003] The applicant has researched the refining process of high-purity scut...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P9/00C07D311/36
Inventor 樊献俄张人伟樊献乔赵尔跃
Owner KUNMING LONGJIN PHARMA
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