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Adhesive patch

A patch and adhesive layer technology, which is applied in viscous dressings, medical science, dressings, etc., can solve the problem of low adhesive patch and drop, and achieve the effect of reducing the frequency of friction

Active Publication Date: 2010-03-03
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Detrimental effects of cold flow include, for example, decreased performance of the adhesive patch when it is removed from the package - this is caused by the protruding adhesive layer components sticking to the inside of the package, and the adhesive patch during adhesion to the skin Edge lifting and coloring, lower effects of adhesive patches with medical effects, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

(1) Preparation of composition for hard adhesive layer formation

High molecular weight polyisobutylene (viscosity average molecular weight 4x10 6 ), medium molecular weight polyisobutylene (viscosity average molecular weight 5x10 4 ), tackifier (alicyclic saturated hydrocarbon resin, softening point 141°C (ring and ball method)) and organic liquid component (isopropyl myristate) in a weight ratio of 17:25:28:30 (total weight 7.5 kg) was mixed in the presence of a toluene / hexane mixed solution (weight ratio 1:1, 17.5 kg) to obtain a composition for forming a hard adhesive layer (total weight 25 kg).

[0090]

(2) Preparation of composition for soft adhesive layer formation

A composition for soft adhesive layer formation was obtained in the same manner as preparing the composition for hard adhesive layer formation, except that the above weight ratio was set to 14:28:28:30.

[0091]

The composition for forming a hard adhesive layer or the composition for forming a so...

Embodiment 8

Adhesive patches were produced in the same manner as in Examples 1-7 to obtain adhesive patch packages, except that by adjusting the size difference in the male type and female type of the pressure cutter module, the adhesive was die-cut out separately. The patch main part and the release liner are then die-cut to form outside the extension of the release liner in the entire edge portion of the adhesive patch main part.

[0094]

experiment example 1

Experimental Example 1 (Evaluation of Adhesive Patch Shape)

The adhesive patch was stained with an aqueous solution of ruthenic acid, and cut with a cryostat (LR-85 produced by YAMATOKOHKI INDUSTRIAL CO., LTD.). PET film and PET nonwoven fabric were measured by FE-SEM (Hitachi, S-4800) at a magnification of 50-1000 times to obtain a cross-sectional view, and read out the scales of the edge part, middle part and center part thickness, and the thickness of the main part of the adhesive patch (the sum of the thickness of the adhesive layer and the thickness of the support). In this case, there were depressions and protrusions on the surface of the PET nonwoven fabric. 10 protrusions were randomly selected in the cross-sectional image, and the average value of the thickness of the PET nonwoven fabric at the protrusions was calculated and taken as the thickness of the PET nonwoven fabric. Then, the thickness of the PET film and the thickness of the above-mentioned PET nonwoven fa...

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PUM

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Abstract

An adhesive patch containing an adhesive patch main part containing a support and an adhesive layer laminated on the support, wherein the adhesive patch main part comprises a peripheral part, a central part, and an intermediate part between the peripheral part and the central part, the intermediate part of the adhesive patch main part has a thickness greater than that of the central part of the adhesive patch main part, and the central part of the adhesive patch main part has a thickness greater than that of the peripheral part of the adhesive patch main part, and a production method thereof.

Description

technical field [0001] The present invention relates to an adhesive patch including a support and an adhesive layer formed on the support, and a manufacturing method thereof. Background technique [0002] In recent years, various adhesive patches and adhesive preparations have been developed. Adhesive patches and adhesive formulations are excellent from the viewpoint of wound protection and / or continuous transdermal administration. [0003] In general, an adhesive patch includes a support made of fabric, plastic film, etc. and an adhesive layer laminated on the support, and usually has a release liner (release) laminated on the adhesive layer. liner) and in a package made of resin film, etc. [0004] In this type of adhesive patch, when the adhesive layer becomes thick, the edge of the adhesive patch is easily rubbed by clothes etc. and rolled up, and the components of the adhesive layer protrude from the edge of the adhesive patch, that is, cold Cold flow, thereb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61F13/02
CPCA61F13/0276A61F2013/00587A61F13/0203
Inventor 播摩润今野昌克桥野亮沼田晃
Owner NITTO DENKO CORP
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