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Application of jade lady variant decoction in preparing medicament for treating hyperthyrea symptom

A technique for thyroid function, addition and subtraction of Yunu decoction, which is applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of preventing and treating hyperthyroidism by adding and subtracting Yunu decoction.

Inactive Publication Date: 2010-01-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] There is no report in the literature that modified Yunu decoction can prevent and treat hyperthyroidism

Method used

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  • Application of jade lady variant decoction in preparing medicament for treating hyperthyrea symptom
  • Application of jade lady variant decoction in preparing medicament for treating hyperthyrea symptom
  • Application of jade lady variant decoction in preparing medicament for treating hyperthyrea symptom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Experimental study on anti-hyperthyroidism effect of modified Yunv decoction

[0021] 1.1 Preparation of experimental drugs

[0022] The composition and adult daily dosage of modified Yunujian: raw gypsum 30g, Anemarrhena 12g, Scrophulariae 12g, rehmannia 18g, Ophiopogon japonicus 18g. Chinese herbal decoction pieces were purchased from Shanghai Yanghetang Pharmaceutical Co., Ltd.

[0023] The drug used in the experiment of this example is the granule obtained by adding and subtracting the water decoction of Yunv Jian after concentration and vacuum drying. The granule is prepared and provided by the Science and Technology Experiment Center of Shanghai University of Traditional Chinese Medicine. 1 g of the granule contains about 2.7 g of the crude drug.

[0024] 1.2 Other medicines

[0025] Methimazole tablets, Beijing Taiyang Pharmaceutical Co., Ltd., batch number: 060501. Levothyroxine sodium (L-Thyroxine Sodium salt), American Sigma Company, batch number: WA1338...

Embodiment 2

[0113] Experimental study on the effect of timosaponins on hyperthyroidism model mice.

[0114] 1. Drugs and reagents

[0115] 1.1 Drugs

[0116] Anemarrhena total saponins, purity > 50%, provided by the Pharmacology Department of Shanghai Second Military Medical University. Methimazole tablets, Beijing Taiyang Pharmaceutical Co., Ltd., batch number: 060501. Levothyroxine Sodium (L-Thyroxine Sodiumsalt), American Sigma Company, batch number: WA13381.

[0117] 1.2 Reagents

[0118] T 4 Radioimmunoassay Kit, Science and Technology Development Center, PLA General Hospital, batch number: 20070330.

[0119] 2. Experimental instruments and equipment

[0120] ECG-92C electrocardiogram machine, Shanghai Optoelectronic Medical Electronic Instrument Co., Ltd. SN-682 radioimmunity gamma counter, Rihuan Instrument Factory, Shanghai Institute of Nuclear Science, Chinese Academy of Sciences. YLS-1A multifunctional mouse autonomic activity recorder, equipment station of Shandong Acad...

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Abstract

The invention discloses application of jade lady variant decoction in preparing a medicament for treating hyperthyrea symptom. The invention also discloses application of the jade lady variant decoction in preparing a medicament for treating hyperthyroid heart disease relevant to the hyperthyrea symptom. The jade lady variant decoction can be complementary with the prior chemical medicament in a hyperthyrea treatment mechanism, can be synergized with the chemical medicament in clinical application so as to reduce the consumption of the chemical medicament and possibly becomes a valuable substituent treatment means for patients who cannot tolerate the adverse reaction of the chemical medicament. The application provides new valuable experimental evidence for developing new Chinese medicament for treating the hyperthyrea symptom and the hyperthyroid heart disease relevant to the hyperthyrea symptom.

Description

technical field [0001] The invention relates to a new medical application of the traditional Chinese medicine classic compound prescription plus-minus Yunujian. Background technique [0002] Hyperthyroidism, referred to as "hyperthyroidism", generally refers to a series of syndromes such as increased basal metabolic rate (BMR) and autonomic nervous system disorders caused by thyroid disease itself. Hyperthyroidism is a clinical syndrome in which the secretion of thyroid hormone increases due to various reasons, resulting in increased excitability of multiple systems of the body and hypermetabolism. , goiter or exophthalmos. [0003] Hyperthyroidism is one of the frequently-occurring and difficult-to-treat diseases in modern society, which seriously endangers the health of modern people. At present, the antithyroid drugs used in clinical practice are mainly thiourea compounds, and their mechanism of action is to inhibit the synthesis of thyroid hormones. , the onset of clin...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K36/8964A61P5/16A61P9/00A61K33/06
Inventor 陈长勋金若敏郭娟李欣
Owner SHANGHAI UNIV OF T C M
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