Composition for curing gastrointestinal functional disorders, preparation method thereof and application thereof in preparing drugs for curing gastrointestinal functional disorders
A technology for gastrointestinal dysfunction and composition, which is applied in the field of compositions for treating gastrointestinal dysfunction, and can solve unseen problems and the like
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experiment example 1
[0054] Experimental Example 1. Effects of Drugs on Mice with Spleen Deficiency
[0055] 1. Animals and grouping: 70 male Kunming mice, weighing 18-22 g, were randomly divided into 7 groups, and each group was fed with 10 mice.
[0056] 2. Administration and experimental methods: Except for the normal control group, all other groups were given 200% rhubarb water decoction, 0.25ml·10g~1, for 10 consecutive days to replicate the mouse model of spleen deficiency. Since the 5th day after administration of rhubarb water decoction, each group was administered by intragastric administration for 6 days. The mice were fasted for 18 hours before the experiment, and 30 minutes after the last administration, the mice were gavaged with 5% Evans blue solution, and the gastrointestinal tract was taken out after the mice were killed, and the distance from the front of the Evans blue to the pylorus was recorded, and its percentage of the small intestine was calculated. long percentage. The th...
experiment example 2
[0064] Experimental Example 2. Regulatory Effects of Drugs on Gastrointestinal Disorders in Rats Induced by Reserpine
[0065] 1. Animals and grouping: 60 healthy adult male SD rats were randomly divided into 6 groups, and 10 rats were raised in each group.
[0066] 2. Administration and experimental methods: (1) normal control group was injected with normal saline intraperitoneally, and distilled water was fed at the same time; (2) gastrointestinal dysfunction model group: reserpine was injected intraperitoneally at 0.5 mg·kg~1, and at the same time fed with Distilled water; (3) Positive group: intraperitoneal injection of reserpine, and at the same time, gavage of Suliqineng; (4) active ingredient group extract group: intraperitoneal injection of reserpine 0.5mg kg~1, and gavage of active ingredient group extract High and low doses. Each group was administered continuously for 14 days. The feces and signs of the rats were observed at any time, and the body weight and food ...
experiment example 3
[0071] The regulation effect of Experimental Example 3 on intestinal flora disorder
[0072] 1. Animals and grouping: 50 Kunming mice, weighing 18-22 g, were randomly divided into 5 groups, and 10 mice were raised in each group.
[0073] 2. Dosing and experimental methods: (1) The normal control group was given intragastric administration of equal volume of distilled water; (2) Model group: daily oral administration of rhubarb liquid 1g / piece; (3) Compound decoction group: daily oral administration of rhubarb Drug solution 1g / carp intraperitoneally, at the same time gavage compound decoction; (4) active ingredient group extract group: daily gavage rhubarb liquid 1g / carp, and simultaneously gavage high and low doses of active ingredient group extract. After 5 consecutive days, the abdominal cavity was opened under aseptic conditions, and the formed feces in the intestine were collected. Dilute the feces with Bifidobacterium and Lactobacillus liquid culture medium to a concentr...
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