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Preparation method of huperzine A

A technology of huperzine A and exchange resin, which is applied in nervous system diseases, organic chemistry, drug combination, etc., can solve the problems of high production cost, serious pollution, and low product yield

Inactive Publication Date: 2009-12-16
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, huperzine A mainly adopts the solvent method, a large amount of acid and alkali are used in the production process, the pollution is serious, and the production cycle is long, the production cost is high, the product yield is low, and the purity is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 10Kg of dry coarse powder of Melaleuca Tower, add 2 times the amount of 1% tartaric acid solution for ultrasonic extraction, power 100W, extract for 10 minutes, filter, pass through 201 × 2 type anion exchange resin, extract the medicinal solution with chloroform, combine the chloroform layers, reduce Chloroform was recovered under pressure and concentrated, added to AB-8 macroporous adsorption resin column, washed with water to remove impurities, eluted with 50% ethanol, collected eluate, recovered ethanol under reduced pressure, added acetone-chloroform (1:1) to crystallize , washed and dried to obtain 1.6 g of huperzine A, which was detected by HPLC with a purity of 95.2%.

Embodiment 2

[0018] Take 10Kg of dry coarse powder of Melaleuca Tower, add 30 times the amount of 1% hydrochloric acid solution for ultrasonic extraction, power 2000W, extract for 30 minutes, filter, pass through 201×4 type anion exchange resin, extract the medicinal solution with chloroform, combine the chloroform layers, and reduce Chloroform was recovered under pressure and concentrated, added to H-103 macroporous adsorption resin column, washed with water to remove impurities, eluted with 90% ethanol, collected eluate, recovered ethanol under reduced pressure, added acetone-chloroform (1:1) to crystallize , washed and dried to obtain 3.4 g of huperzine A, which was detected by HPLC with a purity of 94.4%.

Embodiment 3

[0020] Get 10Kg of dry coarse powder of Melaleuca Tower, add 20 times the amount of 1% tartaric acid solution for ultrasonic extraction, power 600W, extract for 20 minutes, filter, pass through 201×7 type anion exchange resin, extract the medicinal solution with chloroform, combine the chloroform layers, and reduce Chloroform was recovered under pressure and concentrated, added to D-101 macroporous adsorption resin column, washed with water to remove impurities, eluted with 70% ethanol, collected eluate, recovered ethanol under reduced pressure, added acetone-chloroform (1:1) to crystallize , washed and dried to obtain 2.4 g of huperzine A, which was detected by HPLC with a purity of 98.6%.

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Abstract

The invention relates to a preparation method of huperzine A, which is characterized by simple operation and little pollution and comprises the following processing steps: taking huperzine serrate dry coarse powder, adding 2-30 times amount of acid solution for ultrasonic extraction, with power of 100-2000W and extraction time of 10-30min, filtering extracts by anion exchange resins, extracting liquid medicines by chloroform, combining chloroform layers, recovering the chloroform at reduced pressure and concentrating the chloroform, adding the chloroform to a macroporous resin absorption column, using water for elution and impurity removal, using 50-90% of ethanol for elution, collecting eluent, recovering the ethanol at reduced pressure, adding acetone-chloroform for crystallization, washing and drying the crystal, thus obtaining the huperzine A. By adopting the invention to prepare the huperzine A, the product is high in purity and industrialization enlargement is easy to realize.

Description

technical field [0001] The invention relates to a preparation method of huperzine A, in particular to a method for extracting huperzine A from plants. Background technique [0002] Huperzine A (Huperzine A) is an alkaloid extracted from the unique Chinese plant Melaleuca serrata (Huperzine serrata). Currently, it is one of the safest and most effective drugs for the treatment of benign memory impairment and Alzheimer's disease. [0003] In the prior art, huperzine A mainly adopts the solvent method, a large amount of acid and alkali are used in the production process, the pollution is serious, and the production cycle is long, the production cost is high, the product yield is low, and the purity is low. Contents of the invention [0004] The technical problem to be solved by the present invention is to provide a method for preparing huperzine A which is beneficial to large-scale production operations and has high product purity. [0005] In order to solve the problems of...

Claims

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Application Information

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IPC IPC(8): C07D221/22A61P25/28
Inventor 王琳范淦彬
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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