Establishment and application of model for screening medicaments for resisting heterogeneous and multi-reason senile dementias
A technology for senile dementia and model building, applied in drug combinations, medical preparations containing active ingredients, medical science, etc., can solve the problems of ignoring the heterogeneity and multifactoriality of senile dementia
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[0007] 1 Establishment of senile dementia model
[0008] 1.1 Experimental grouping
[0009] 55 healthy Wistar rats were randomly divided into 3 groups: blank group, sham injury group and model group. There were 15 rats in the blank group and 20 rats in each experimental group.
[0010] 1.2 Modeling method
[0011] The blank group will not be treated. The model group was given intraperitoneal injection of D-gal (50 mg / kg d) respectively to cause subacute aging, and after 4 weeks, the bilateral common carotid arteries were ligated repeatedly to cause cerebral ischemic lesions (360 mg / kg intraperitoneal chloral hydrate in rats) Inject anesthesia, make an incision after routine disinfection in the middle of the neck, separate the bilateral common carotid arteries, and set the "4" silk thread buckle. Tighten the thread buckle, block the blood flow for 10 minutes, loosen the thread button to allow the blood to perfuse for 10 minutes, and then block again Blood flow was observed ...
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