Novel preparation method of selenated polysaccharide

Abstract

The invention discloses a novel preparation method of selenated polysaccharide,specifically comprising the steps of: dissolving the polysaccharide into selenate-containing solution; freezing and drying after adjusting pH value; heating up the frozen and dried selenate-polysaccharid mixture for 1-3 days under drying condition to have a selenation reaction; and obtaining the selenated polysaccharide after dialyzing, freezing and drying, etc. The invention has the advantages that: organic solvent is not completely used in the whole preparation process and selenated products can completely avoid environment pollution; process flow is simple, condition is controllable, production cost is low, and the selenated polysaccharide is convenient to industrially produce; and the selenated polysaccharide can be taken as organic selenium supplying agent to be applied to foods, health products or fodders so as to provide selenium which is necessary for human or animal. Furthermore, the selenated polysaccharide has an immunity regulating effect and good oxidation resistance and anticancer capability, and plays an important role in developing anti-cancer drugs or cosmetics, etc.

Description

technical field [0001] The present invention relates to a new method for preparing selenated polysaccharide without using organic solvent. Background technique [0002] Selenium has been recognized by the United Nations Health Organization as an important trace element necessary for the human body. Studies have shown that a variety of diseases, such as Keshan disease, diabetes, cardiovascular disease, cataract, aging, etc., are related to selenium deficiency in the body. Over the years, a lot of research has been done on the biological function of selenium at home and abroad, especially the relationship between selenium and tumors. Relationship, so that the study of selenium from nutritional function to drug therapy has become a very active field in selenium chemistry today. In addition, selenium is an effective antioxidant, which can scavenge free radicals and reduce serum total cholesterol, triglycerides and lipid peroxides. At the same time, selenium can also regulate th...

AI Technical Summary

Problems solved by technology

Gong Xiaozhong of Shenzhen University et al. (Research and Development of Natural Products, 1997, 10, 26) used selenium oxychloride-pyridine to synthesize selenated Huang's polysaccharide, but the disadvantage of this selenated polysaccharide preparation method is that pyridine was used in the preparation process. , and residual organic solvents such as pyridine will have an adverse effect on its application in food or medicine. In addition, the selenium content of the selenated product prepared by this method is only 1.68%; Homemade selenium oxychloride (SeOCl 2 ) to selenate dextran to obtain selenated dextran with a selenium content of 0.60%; in 2008, Guo Yong from the Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, etc. invented the synthesis of selenated polysaccharides in dioxane or toluene medium The method (Chinese patent, application number: 200610104992.8), according to the different types of polysaccharides, obtains selenated polysaccharides with a selenium content of only 0.08-1.10%, and this preparation method uses toxic organic compounds such as dioxane, toluene or amines. Solvents, such residual reagents may affect the food safety of selenated polysaccharides, while the use of organic solvents may pollute the environment

However, this preparation method requires the use of chemical reagents such as barium salts, nitric acid, and ethanol, and a high-shear mixer is required during the preparation process, which may increase production costs

[0005] In conclusion, in the current preparation process of selenated polysaccharides, toxic organic solvents such as pyridine and benzene are commonly used, and one of the uses of selenated polysaccharides is to use them in food, so the residual reagents may affect its application

Secondly, the selenium content of selenated polysaccharides prepared by these methods is generally not high

In addition, the use of strong acid as a catalyst makes the reaction violent, difficult to control, and has potential environmental impact

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