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Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof

A technology for diagnostic reagents and nuclear medicine, applied in the field of preparation of stable isotope reagents, can solve the problems of low yield of product oxygen 18, reduced yield of oxygen 18 water, running loss of double-standard water raw materials, etc., so as to improve the utilization value and reduce the The effect of running loss and reducing production cost

Active Publication Date: 2009-11-11
SHANGHAI RES INST OF CHEM IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantages are: 1. The deuterium gas is directly emptied without utilization
In fact, deuterium gas can be used to prepare heavy water and deuterated reagents, which also has high economic value; second, the electrolysis process will cause serious loss of double-labeled water raw materials, and the yield of product oxygen 18 is low; third, the electrolysis process will have A small amount of deuterium leaks into the oxygen 18 gas, and enters the oxygen 18 water product in the subsequent catalytic reaction process, which ultimately affects the quality of the product; 4. The oxygen 18 gas produced by electrolysis will entrain a small amount of double-labeled water, which will eventually affect the quality of the product. 5. In order to be used as a diagnostic reagent in nuclear medicine, oxygen-18 water must go through refining and purification processes such as removing organic matter, removing inorganic matter, removing bacteria, and removing heat sources. These processes are relatively complicated and lengthy, and will reduce the abundance of oxygen-18, Further reduce the yield of oxygen 18 water, affect product quality, and increase the production cost of nuclear medicine diagnostic reagent-oxygen 18 water

Method used

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  • Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof
  • Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof
  • Method for preparing nuclear medicine diagnostic reagent oxygen-18 water and device thereof

Examples

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Effect test

Embodiment 1

[0022] Such as figure 2 Shown is a flow chart of the present invention for the preparation of nuclear medicine diagnostic reagent-oxygen 18 water. The present invention is used in the preparation method of nuclear medicine diagnostic reagent-oxygen 18 water. First, the raw material of deuterium oxygen 18 double-labeled water obtained by industrial water rectification is added to an electrolytic cell for electrolysis, and the deuterium gas obtained by electrolysis is prepared into heavy deuterium water through a catalytic reaction. Utilize deuterium gas; the oxygen 18 gas obtained by electrolysis first undergoes a catalytic purification process, and then uses a dry adsorption process to obtain high-purity oxygen 18 gas, which is directly catalytically reacted with platinum mesh and high-purity hydrogen at high temperature to directly obtain quality Qualified diagnostic reagent for nuclear medicine - oxygen 18 water.

[0023] Such as image 3 Shown is a schematic diagram of a...

Embodiment 2

[0029] see Figure 2~3 , a preparation method for nuclear medicine diagnostic reagent oxygen 18 water, the method is to use the deuterium oxygen 18 double-labeled water obtained by the oxygen isotope water rectification industrial separation device as a raw material, and first obtain high-purity deuterium by electrolysis, purification and purification High-purity deuterium gas and high-purity oxygen 18 gas, and then use high-temperature platinum mesh catalysis to make high-purity deuterium gas and high-purity oxygen react at high temperature to obtain heavy deuterium water, and use high-temperature platinum mesh catalysis to make high-purity oxygen 18 gas and high-purity hydrogen The reaction directly obtains a highly purified reagent-oxygen 18 water that can be used for nuclear medicine diagnosis.

[0030] The above method is implemented with the following device, which includes deuterium oxygen 18 double-labeled water electrolyzer 1, raw material storage tank 2, raw material...

Embodiment 3

[0033] see Figure 2~3 , a preparation method for nuclear medicine diagnostic reagent oxygen 18 water, the method is to use the deuterium oxygen 18 double-labeled water obtained by the oxygen isotope water rectification industrial separation device as a raw material, and first obtain high-purity deuterium by electrolysis, purification and purification High-purity deuterium gas and high-purity oxygen 18 gas, and then use high-temperature platinum mesh catalysis to make high-purity deuterium gas and high-purity oxygen react at high temperature to obtain heavy deuterium water, and use high-temperature platinum mesh catalysis to make high-purity oxygen 18 gas and high-purity hydrogen The reaction directly obtains a highly purified reagent-oxygen 18 water that can be used for nuclear medicine diagnosis.

[0034] The above method is implemented with the following device, which includes deuterium oxygen 18 double-labeled water electrolyzer 1, raw material storage tank 2, raw material...

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Abstract

The invention relates to a method for preparing nuclear medicine diagnostic reagent oxygen-18 water and a device thereof. The method comprises the steps of: utilizing an oxygen isotope water industrial rectifying separation device to obtain deuterium oxygen 18 doubly-labelled water as material; carrying out steps of electrolysis, purification and filtering to obtain high-purity deuterium and high-purity oxygen-18 gas; adopting a high-temperature platinum mesh to carry out catalyzing so as to lead the high-purity deuterium to react with the high-purity oxygen-18 gas at high temperature to generate deuterium water; and adopting the high-temperature platinum mesh to carry out catalyzing to lead the high-purity oxygen-18 gas to directly react with high-purity hydrogen to obtain the highly-purified oxygen-18 water adopted as the diagnostic reagent of nuclear medicine. Compared with the prior art, the invention which not only can make full use of the deuterium oxygen 18 doubly-labelled water to prepare the nuclear medicine diagnostic reagent oxygen-18 water and utilize by-product deuterium to prepare deuterium water but also can reduce process steps, enhance quality and yielding of oxygen-18 water of nuclear medicine and reduce product cost really has simple process and better effect.

Description

technical field [0001] The invention belongs to the technical field of preparation of stable isotope reagents, and in particular relates to a preparation method and device for oxygen 18 water, a nuclear medicine diagnostic reagent. Background technique [0002] Oxygen in nature has three stable isotopes, their mass numbers are 16, 17, and 18, and their abundances in natural water are 99.76%, 0.04%, and 0.2% atoms respectively. Among them, 16O is common oxygen element, and 18O and 17O are heavy oxygen elements. Oxygen 18 water is a hydride of the oxygen 18 isotope, which has the same properties as ordinary water (H 2 16 O) The same physicochemical properties. [0003] Oxygen 18 isotopes can be bombarded by medical cyclotrons to obtain fluorine 18 ions, and its labeled positron imaging drug 18F-FDG is mainly used in nuclear medicine positron emission computed tomography (Positron Emission Computed Tomography, PET), so oxygen 18 Water is widely demanded as a nuclear medicin...

Claims

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Application Information

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IPC IPC(8): C01B5/00C25B1/04
CPCY02E70/10Y02E60/366Y02E60/36
Inventor 肖斌李猷周建跃姜永悦刘严秦川江
Owner SHANGHAI RES INST OF CHEM IND
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