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Application of amlodipine to preparation of medicaments for curing phoproliferative diseases

A proliferative disease, amlodipine pharmacy technology, applied in the field of the use of amlodipine in the preparation of a drug for the treatment of cell proliferative diseases, and can solve the problems such as the lack of research on the effect of tumor

Inactive Publication Date: 2009-11-04
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above research reports only use racemic amlodipine to conduct a small amount of research on 3 kinds of tumors, and there is no research on the effect on other tumors, and there is no research report on the effect of levoamlodipine on various tumors

Method used

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  • Application of amlodipine to preparation of medicaments for curing phoproliferative diseases
  • Application of amlodipine to preparation of medicaments for curing phoproliferative diseases
  • Application of amlodipine to preparation of medicaments for curing phoproliferative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Inhibitory effect of amlodipine and levamlodipine on the growth of gastric cancer cell line SGC-7901

[0012] Experimental materials: amlodipine tartrate, amlodipine maleate, amlodipine besylate and levamlodipine tartrate, levamlodipine maleate, and levamlodipine besylate were supplied by CSPC Zhongqi Pharmaceutical Co., Ltd. Technology (Shijiazhuang) Co., Ltd., gastric cancer cell SGC-7901 was cryopreserved by CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Pharmacology Center, thiazolyl blue (MTT), RPMI1640 medium and trypsin were purchased from Sigma Company, for injection Fluorouracil deoxynucleosides were purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., and other chemical reagents were of domestic analytical grade.

[0013] Experimental method: SGC-7901 cells in the logarithmic growth phase were taken, washed with phosphate buffer, digested with trypsin, and adjusted to a cell density of 6×10 with fresh RPMI1640 culture medium. 4 c...

Embodiment 2

[0020] Example 2 The Growth Inhibition Effect of Amlodipine and Levoamlodipine on Leukemia Cell HL60

[0021] Experimental materials: amlodipine tartrate, amlodipine maleate, amlodipine besylate and levamlodipine tartrate, levamlodipine maleate, and levamlodipine besylate were supplied by CSPC Zhongqi Pharmaceutical Co., Ltd. Technology (Shijiazhuang) Co., Ltd., leukemia HL60 cells were cryopreserved by CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Pharmacology Center, thiazolyl blue (MTT) and RPMI1640 medium were purchased from Sigma Company, fluorouracil deoxynuclear for injection Glycosides were purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., and other chemical reagents were of domestic analytical grade.

[0022] Experimental method: Take the leukemia HL60 cells in the logarithmic growth phase, adjust the cell density to 5×10 with fresh RPMI1640 culture medium 4 cell / ml, seeded in a 96-well plate at 200 μl / well. Set 5% CO 2 After incubating in t...

Embodiment 3

[0029] Embodiment 3 Amlodipine and levamlodipine inhibit the growth of liver cancer cells HepG2

[0030] Experimental materials: amlodipine tartrate, amlodipine maleate, amlodipine besylate and levamlodipine tartrate, levamlodipine maleate, and levamlodipine besylate were supplied by CSPC Zhongqi Pharmaceutical Co., Ltd. Technology (Shijiazhuang) Co., Ltd., liver cancer cells HepG2 were cryopreserved by CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Pharmacology Center, thiazolyl blue (MTT), RPMI1640 medium and trypsin were purchased from Sigma Company, and fluorourea for injection Pyrimidine deoxynucleosides were purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., and other chemical reagents were of domestic analytical grade.

[0031] Experimental method is the same as embodiment 1.

[0032] Experimental results:

[0033] Table 3. Growth inhibitory IC of amlodipine and levamlodipine on liver cancer cells HepG2 50 value

[0034]

[0035] As can be s...

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Abstract

The invention relates to an application of amlodipine to the preparation of medicaments for curing phoproliferative diseases. The amlodipine is selected from racemic amlodipine, levorotatory amlodipine and pharmaceutically acceptable salts, and the phoproliferative diseases particularly refer to various malignant tumors, such as leukemia, lung cancer, gastric cancer, liver cancer, ovarian cancer, prostatic cancer, cervical cancer, breast cancer and squamous carcinoma.

Description

technical field [0001] The present invention relates to the use of amlodipine in the preparation of medicines for treating cell proliferative diseases. Refers to various malignant tumors. Background technique [0002] Tumor is a major disease that endangers people's health and life. According to the statistics of the World Health Organization, among the 6 billion people in the world, an average of 6.9 million patients die of malignant tumors every year, and 8.7 million new cases occur. At present, there are about 2.2 million cancer patients in my country. cancer patients, and the number is increasing year by year. Therefore, governments, institutions and pharmaceutical companies of various countries have long attached great importance to tumor research and anti-tumor drugs. In the research of anti-tumor drugs, although significant progress has been made, there are hundreds of anti-tumor drugs clinically, and the survival time of cancer patients is significantly prolonged, b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61P35/00
Inventor 张宏武张福军孙京国陈欣然杨汉煜肖乔
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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