Bile preparations for colorectal disorders

A colonic, rectal technology in the field of bile preparations for colorectal conditions that addresses logistical and financial constraints, difficulty identifying high-risk populations, and high costs

Inactive Publication Date: 2009-09-30
柳署弘
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Prevention of cancerous lesions (cancerous lesions) in CRC through endoscopic screening is promising, but costs are high and identification of high-risk groups is difficult
Screening average-risk and high-risk populations for CRC may also have logistical and financial constraints

Method used

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  • Bile preparations for colorectal disorders
  • Bile preparations for colorectal disorders
  • Bile preparations for colorectal disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Example 1: Preparation of Bile Acid Solution - Formulation 60

[0120] Sodium hydroxide solution was prepared by dissolving 5.2 g of ultra-pure grade (EP) NaOH in 100 mL of USP pharmaceutical grade water. Next, 48 g of UDCA was added to prepare clear solution A.

[0121] Clear solution B was prepared by completely dissolving 320 g of food grade (NF) maltodextrin and 320 g of food grade (NF) soluble resistant starch in 300 mL of USP pharmaceutical grade water.

[0122] Solution A and solution B were combined under stirring, then an appropriate amount of food grade sodium bisulfite (0.3 g / kg) was added to the clear solution. Food grade dilute phosphoric acid was added to adjust the pH of the final solution (pH: 6-7.5). The final solution can be filtered and / or heated to sterilize at 80°C to 100°C, if desired.

Embodiment 2

[0123] Example 2: Preparation of Bile Acid Solution - Formulation 25

[0124] A sodium hydroxide solution was prepared by dissolving 2.7 g of EP NaOH in 100 mL of USP pharmaceutical grade water. Next, 25 g of UDCA was added to prepare clear solution A.

[0125] Clear solution B was prepared by completely dissolving 500 g of NF maltodextrin and 150 g of NF soluble resistant starch in 400 mL of USP pharmaceutical grade water.

[0126] Solution A and solution B were combined under stirring, then an appropriate amount of food grade sodium bisulfite (0.3 g / kg) was added to the clear solution. Food grade dilute phosphoric acid was added to adjust the pH of the final solution (pH: 6-7.5). The final solution can be filtered and / or heated to sterilize at 80°C to 100°C, if desired.

Embodiment 3

[0127] Example 3: Preparation of Bile Acid Solution - Formulation 20

[0128] A sodium hydroxide solution was prepared by dissolving 2.2 g of EP NaOH in 100 mL of USP pharmaceutical grade water. Next, 20 g of UDCA was added to prepare a clear solution A.

[0129] Clear solution B was prepared by completely dissolving 500 g of NF maltodextrin and 150 g of NF soluble resistant starch in 400 mL of USP pharmaceutical grade water.

[0130] Solution A and solution B were combined under stirring, then an appropriate amount of food grade sodium bisulfite (0.3 g / kg) was added to the clear solution.

[0131] Food grade dilute phosphoric acid was added to adjust the pH of the final solution (pH: 6-7.5). The final solution can be filtered and / or heated to sterilize at 80°C to 100°C, if desired.

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Abstract

The present disclosure relates to methods and compositions to ameliorate or treat at least one symptom of colorectal cancer and / or adenomatous polyposis coli (APC). For example, some embodiments of the methods and compositions may reduce recurrence of colorectal adenomas and / or extend the life of a subject having colorectal cancer and / or APC. Some embodiments of the disclosure include maintaining a the total body weight in a subject having colorectal cancer and / or APC. According to some embodiments, a method of the disclosure may include administering a bile acid composition to a subject. A bile acid composition may include, in some embodiments, an aqueous solution that is free or substantially free of precipitates or particles. A aqueous solution may include (1) a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and / or 7-ketolithocholic acid, (2) a carbohydrate, and (3) water. An aqueous composition may further include an alkali.

Description

technical field [0001] The present disclosure relates to methods and compositions of one or more bile acids that can be used to ameliorate one or more symptoms of a colorectal disorder. Background technique [0002] Colorectal cancer (CRC) is one of the most common forms of gastrointestinal cancer in the world today and is the leading cause of cancer-related death worldwide. In the Asia-Pacific region, it is the fastest-emerging gastrointestinal cancer. Colorectal cancer is the third most common cancer in the world and the second leading cause of cancer death among American men and women. Cancer of the colon and rectum is rare in developing countries but is the second most common malignancy in affluent societies. Worldwide more than 940,000 cases occur annually and almost 500,000 patients die from it each year. The American Cancer Society estimates that there were approximately 106,680 new cases of colon cancer and 41,930 new cases of rectal cancer in the United States in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61P1/00A61P35/00
CPCA61K35/413A61K31/575A61K9/08A61K31/718A61K45/06A61P1/00A61P35/00A61P43/00A61K2300/00
Inventor 柳署弘
Owner 柳署弘
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