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Biocompatibility pre-gelatinized modified starch and preparation thereof

A technology of biocompatibility and modified starch, applied in application, medical science, absorbent pads, etc., can solve the problems of poor water absorption, difficult to achieve hemostasis, small starch, etc., achieve non-toxic side effects, avoid residues, and be safe to use Effect

Inactive Publication Date: 2012-04-25
纪欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] Natural starch is difficult to achieve the purpose of hemostasis due to its small and light granules and poor water absorption at room temperature

Method used

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  • Biocompatibility pre-gelatinized modified starch and preparation thereof
  • Biocompatibility pre-gelatinized modified starch and preparation thereof
  • Biocompatibility pre-gelatinized modified starch and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] A biocompatible pregelatinized modified starch is pregelatinized hydroxypropyl distarch phosphate, and the original starch (tapioca starch) is etherified, crosslinked, and esterified with chemical reagents such as propylene oxide and phosphoric acid. After multiple times of denaturation, it is made into hydroxypropyl distarch phosphate, and then pregelatinized and denatured by spray drying method to make pregelatinized hydroxypropyl distarch phosphate. Then put the pre-gelatinized hydroxypropyl distarch phosphate raw material in the boiling machine at 40-50°C, add distilled water, undergo coagulation, pelletizing, and sieve to make modified starch 51# (manufacturer Starch Medical Inc. batch number 071025), the molecular weight is 10,000-2,000,000 Daltons, the particle size is 10-1000 μm, and the starch granules with a particle size of 30-500 μm account for not less than 95% of the total starch granules, and the particle size is preferably 50-500 μm.

[0097] The viscosi...

Embodiment 2

[0106]A biocompatible pregelatinized modified starch is pregelatinized hydroxyethyl starch. After the original starch (tapioca starch) is etherified and denatured to make hydroxyethyl starch, the hydroxyethyl starch is processed by roller drying method. Starch pre-gelatinization and denaturation to make pre-gelatinized hydroxyethyl starch, and then put the pre-gelatinized hydroxyethyl starch raw material in a boiling machine at 40-50°C, add distilled water, and undergo coagulation, pelleting, and sieving. Pregelatinized hydroxyethyl starch 88#*, molecular weight 10,000-500,000, particle size 10-1000 μm, and starch granules with a particle size of 30-500 μm account for not less than 95% of the total starch granules, particle size Preferably, it is 50 to 500 μm.

Embodiment 3

[0108] A biocompatible pregelatinized modified starch, which is pregelatinized carboxyethyl starch. After the original starch (potato starch) is etherified and denatured to make carboxyethyl starch, it is pregelatinized and denatured by roller drying method Pre-gelatinized carboxyethyl starch is made, and then the pre-gelatinized carboxyethyl starch raw material is placed in a boiling machine at 40-50°C, distilled water is added, and pre-gelatinized starch is made through coagulation, pelletizing and sieving. Carboxyethyl starch, the molecular weight is 15,000-2,000,000, the particle size is 10-1000 μm, and the starch granules with a particle size of 30-500 μm account for not less than 95% of the total starch granules, and the particle size is preferably 50-500 μm.

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Abstract

The invention relates to a biocompatible pre-gelatinized modified starch. The water absorbency is not less than one time, and the biocompatible pre-gelatinized modified starch is taken as biocompatible hemostatic material, biocompatible anti-blocking material, biocompatible tissue-healing promoting material, biocompatible surgical sealant or biocompatible wound closure tissue glue. The invention has the advantages that the biocompatible pre-gelatinized modified starch is directly acted on the wounded area with blood for immediately stopping bleeding, has obviously increased water absorbency and speed of water absorption and greater viscosity and stickiness and further plays the role in preventing the tissue and the blood vessel from being damaged during the process of stopping bleeding; the modified starch is easy to swell or dissolve in water, and is washed by normal saline after the bleeding stopping so as to reduce the residual in the body, to be favorable for wound healing and to avoid the pain due to tearing the gauze and the bandage out; the pre-gelatinized modified starch has the actions of bacterial resistance and anti-inflammatory; and the pre-gelatinized modified starch is stable, not easy to decompose, long in guarantee period, convenient for storage, resistant at high pressure and low pressure, resistant at high temperature and low temperature and not easy to change the physicochemical characteristics.

Description

technical field [0001] The present invention relates to a biocompatible modified starch material, especially a kind of directly acting on the wounds of humans, mammals, etc., including wounds with blood or exudate, as a hemostatic material, or further used in the human body Body surface, tissues and organs, and tissues or organs in body cavities, as anti-adhesion materials, materials for promoting tissue healing, surgical sealants, wound-free tissue glue, and biocompatible pregelatinized denaturation that can be absorbed by humans and animals Starch and its preparation method. Background technique [0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will be lost, and it is necessary to use hemostatic means in time. The use of biocompatible absorbable hemostatic materials to stop bleeding on bleeding wounds is a common means of hemostasis, and there is an urgent need for hemostasis in surgical hemostasis, trauma, first aid, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B31/00C08J3/12D06M15/11A61L24/08A61L15/28A61L31/04
Inventor 纪欣
Owner 纪欣
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