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Medicine of effective fractions of compounded prescription of Huomai Tiaozhi capsule and preparation technology thereof

A technology of effective parts and preparation technology, which is applied in the field of drugs and preparation technology of effective parts of Huomaitiaozhi Capsules compound, can solve the problems of human toxic and side effects, liver and kidney damage, etc., achieve no toxic and side effects, high extraction efficiency, easy-to-operate effect

Inactive Publication Date: 2009-07-29
福建中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical practice, Western medicine is generally used for lipid-lowering treatment, mainly for lowering cholesterol or triglyceride. Long-term use will cause many toxic and side effects to the human body, such as damage to the liver and kidneys, etc.

Method used

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  • Medicine of effective fractions of compounded prescription of Huomai Tiaozhi capsule and preparation technology thereof
  • Medicine of effective fractions of compounded prescription of Huomai Tiaozhi capsule and preparation technology thereof
  • Medicine of effective fractions of compounded prescription of Huomai Tiaozhi capsule and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Mix Astragalus, Danshen, and Tribulus terrestris according to the above formula, and extract twice with 8 times the weight of the raw material for 1 hour each time. The extracts are combined and filtered. The filtrate is precipitated with ethanol with a concentration of 70%. Let it stand overnight, filter, recover the alcohol precipitation filtrate, concentrate the alcohol precipitation filtrate in a boiling water bath at 100°C and dilute to a concentrated solution with a total saponin concentration of 1g / ml, and apply the concentrated solution to an AB-S type macroporous adsorption resin column. Elute with distilled water 8 times the volume of the resin and 60% ethanol successively, with an elution flow rate of 1.5ml / min, collect the 60% ethanol eluate, and evaporate the eluate in a boiling water bath at 100℃ to obtain total saponin .

[0020] Mix Ligustrum and Rhubarb according to the above formula, and extract twice with 80% ethanol at a weight ratio of 8 times to the ra...

Embodiment 2

[0023] Mix Codonopsis, Salvia and Tribulus terrestris according to the above formula, and extract twice with water of 10 times the weight ratio of the raw materials for 1 hour each time. The extracts are combined and filtered. The filtrate is precipitated with ethanol with a concentration of 80%. Let it stand overnight, filter, recover the alcohol precipitation filtrate, concentrate the alcohol precipitation filtrate in a boiling water bath at 100°C and dilute to a concentrated solution with a total saponin concentration of 1g / ml, and apply the concentrated solution to an AB-S type macroporous adsorption resin column. Elute with distilled water 8 times the volume of the resin and 60% ethanol successively, with an elution flow rate of 1.5ml / min, collect the 60% ethanol eluate, and evaporate the eluate in a boiling water bath at 100℃ to obtain total saponin .

[0024] Mix Ligustrum and Rhubarb according to the above formula, and extract twice with 80% ethanol at a weight ratio of 8 ...

Embodiment 3

[0027] Mix the astragalus, hawthorn and tribulus according to the above formula, extract 3 times with 8 times the weight of the raw material, 1 hour each time, combine the extracts, filter, and settle the filtrate with ethanol with a concentration of 75%. Let it stand overnight, filter, recover the alcohol precipitation filtrate, concentrate the alcohol precipitation filtrate in a boiling water bath at 100°C and dilute to a concentrated solution with a total saponin concentration of 1g / ml, and apply the concentrated solution to an AB-S type macroporous adsorption resin column. Elute with distilled water 8 times the volume of the resin and 60% ethanol successively, with an elution flow rate of 1.5ml / min, collect the 60% ethanol eluate, and evaporate the eluate in a boiling water bath at 100℃ to obtain total saponin .

[0028] Mix Ligustrum and Rhubarb according to the above formula, and extract twice with 80% ethanol at a weight ratio of 8 times to the raw material for 2 times, 1h ...

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Abstract

The invention provides a drug for an effective fraction group of a pulse-activating and fat-regulating capsule compound and a process for preparing the same. The effective fraction group comprises total saponin and total organic acid; drugs for preparing the total saponin comprise astragalus root, radix codonopsis pilosulae or Wu Chia Pee, radix salivae miltiorrhizae, turmeric or hawkthorn and caltrop or radices puerarire; drugs for preparing the total organic acid comprise privet and rhubarb or semen cassiae torae; the drugs for preparing the total saponin are mixed, extracted with water, filtered and subjected to ethanol precipitation; a water bath concentrated solution of an ethanol precipitation filtrate is subjected to macroporous resin column and elution by distilled water and ethanol sequentially; an eluant is evaporated to prepare the total saponin; the drugs for preparing the total organic acid are mixed, extracted by ethanol and filtered; a filtrate is condensed in a water bath, is subjected to macroporous resin column and gradient elution by distilled water and ethanol sequentially; an eluant is evaporated to prepare the total organic acid; and the total saponin and the total organic acid are mixed to prepare the effective fraction group. A drug formula totally adopts pure natural Chinese medicine materials, reduces fat, protects liver and has no toxicity and no side effect on human body, simple preparation process, easy operation and high extraction efficiency.

Description

[0001] Application date of the original application: January 12, 2007 [0002] Application number: 200710008433.1 [0003] Invention name: Medicinal formula and preparation process of active part group of Huomai Tiaozhi capsule compound Technical field [0004] The invention relates to a medicine formula and a preparation process, and more specifically to a medicine and a preparation process of the effective part group of a Huomai Tiaozhi capsule compound. Background technique [0005] At present, with the improvement of people's living standards, the intake of high-fat and high-calorie foods is also increasing. The incidence of fatty liver, hyperlipidemia, obesity, arteriosclerosis, cerebral thrombosis, coronary heart disease and other diseases is increasing year by year, and is showing a younger trend. Clinically, western medicine is generally used for lipid-lowering treatment, mainly for lowering cholesterol or triglycerides. Long-term use will cause many toxic and side effects...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K36/9066A61P1/16A61P3/06A61P3/04A61P9/10A61P7/02
Inventor 张小如徐榕青李孝栋王英豪
Owner 福建中医学院
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