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Senescence inhibitor

An inhibitor and aging technology, applied in the field of motor function improver and muscle aging inhibitor, can solve the problem of not knowing the role of catechins

Active Publication Date: 2009-07-15
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of catechins in combination with amino acids or both in suppressing aging-associated declines in muscle mass and muscle strength is largely unknown

Method used

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Examples

Experimental program
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Effect test

preparation example 1

[0235] Preparation example 1 (container-packed beverage for anti-aging)

[0236] According to the formulation and conditions shown in Table 11, the aging-suppressing container-packed beverage was prepared. In addition, the composition of the tea extract (tea catechin) in this container-packed drink is shown in Table 12. Both the preservation stability and flavor of this drink were favorable.

[0237] Table 11

[0238] Composition of tea beverages (g / 100mL)

[0239] green tea drink oolong tea drink Green Tea Extract (g)

Oolong Tea Extract (g)

Tea extract (g)

Purified water (g)

Sodium Ascorbate (g) 17.5

0

0.37

balance

0.05 0

8

0.48

balance

0.05 pH (after sterilization) 5.98 5.87 Sterilization temperature (℃) 133 134 Sterilization heating time (seconds) 30 30 container PET container PET container

[0240] Table 12

[0241] Catechin composition in beverages (mg / 500mL)

[0...

preparation example 3

[0248] Preparation example 3 Jelly food for anti-aging

[0249] Mixed gelling agent of carrageenan and locust bean gum 0.65%, grapefruit 50% concentrated fruit juice 5.0%, citric acid 0.05%, vitamin C 0.05%, tea catechin (TEAVIGO (DSM Nutritional·Products)) 0.54 % mixed, adjusted to 100% by adding water, and dissolved at 65°C. Add a small amount of grapefruit essence, keep at 85°C for 5 minutes for sterilization, and then pour into a 100mL container. Leave it to stand for 8 hours and slowly cool to 5° C. to obtain a jelly food containing catechins.

preparation example 4

[0250] Preparation Example 4 Vitamin Oral Liquid for Antiaging

[0251] 800mg taurine, 2000mg sucrose, 50mg caramel, 30mg sodium benzoate, 5mg vitamin B 1 Nitrates, B vitamins 20mg 2 , 20mg vitamin B 6 , 2000mg vitamin C, 100mg vitamin E, 2000IU vitamin D 3 , 20 mg of nicotinic acid amide and 100 mg of tea catechin (Polyphenon 70S (Mitsui Norin)) were added to an appropriate amount of purified water for dissolution, adjusted to pH 3 with phosphoric acid aqueous solution, and then added with purified water to make the total amount reach 50 mL. This was sterilized at 80° C. for 30 minutes to obtain a catechin-containing vitamin oral liquid.

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Abstract

Provision of a drug, a quasi-drug, and a food or beverage, which are effective for senescence inhibition, mitochondrial function improvement, muscle dysfunction inhibition, muscular atrophy inhibition, prevention of a bedridden state, muscle senescence inhibition, or motor function improvement. A senescence inhibitor, a mitochondrial function-improving agent, a muscle dysfunction inhibitor, a muscular atrophy inhibitor, and an agent for preventing a bedridden state, containing a catechin as an effective ingredient. A muscle senescence inhibitor and a motor function-improving agent, containing a catechin and an amino acid as effective ingredients.

Description

technical field [0001] The present invention relates to an aging inhibitor, an agent for improving mitochondrial function, an inhibitor for muscle function decline, an inhibitor for muscle atrophy, a preventive agent for bedridden, an inhibitor for muscle aging, and an agent for improving motor function. Background technique [0002] Aging is roughly divided into physiological aging and pathological aging. Physiological aging is the aging that will inevitably occur with the increase of age. There will be changes in hair, skin, eyes, bones, brain, etc., and the decline of motor function and energy metabolism. In recent years, it has been reported that the variation and damage of mitochondrial DNA, that is, the decline of mitochondrial function, is related to the decline of energy metabolism caused by aging (refer to Non-Patent Document 1). [0003] On the other hand, the decline in muscle strength and endurance caused by aging reduces the ability to perform daily activities....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A23L1/30A61K36/00A61K36/18A61P21/00A61P43/00
Inventor 太田宣康原水聪史村瀬孝利
Owner KAO CORP
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