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Degradable artificial trachea stent and production method thereof

An artificial trachea and a manufacturing method technology, applied in the field of biomedicine, can solve the problems of stenosis of the lumen, difficulty in breathing, and inability to climb and stretch the tracheal epithelium, and achieve the effects of less irritation, strong anti-infection ability, and beneficial to crawling repair.

Inactive Publication Date: 2009-07-15
唐华 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Stainless steel wire, titanium mesh, Marlex mesh, etc. have been used in the research of perforated artificial trachea, but because they cannot be degraded, they exist in the body for a long time, leading to inevitable infection, chronic ulceration of the tracheal bed, leakage and granulation tissue hyperplasia, and finally stenosis of the lumen , causing difficulty breathing
Therefore, tissue-engineered artificial trachea has become a hotspot in the research of artificial trachea at present. It uses degradable biomaterials, combined with cell separation and culture technology, to regenerate the trachea. It can only ensure the patency of the trachea, but the length of the repair is limited, which can only reach 2.5cm. In addition, its inner surface cannot climb and stretch the tracheal epithelium, and it cannot achieve the reconstruction of the anatomical structure.

Method used

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  • Degradable artificial trachea stent and production method thereof
  • Degradable artificial trachea stent and production method thereof
  • Degradable artificial trachea stent and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] ① The warp and weft raw materials are polyglycolide monofilaments with a diameter of 0.15mm; the width of A (E) part is 2cm, and the density of warp and weft is 40×40 / cm; the width of part B (F) is 1.5cm, and the density of warp and weft is 40×45 / cm ; Fabric composition is ABABABA;

[0030] ② Loosely insert the anti-blocking mold into the small tubular ring composed of double-layer pipe walls surrounding the longitudinal axis of the pipe wall;

[0031] ③Soak in 2% collagen solution for 3 minutes, take it out, and dry;

[0032] ④Apply 2% chitosan solution evenly and tightly on the inner layer to close the mesh and maintain air tightness;

[0033] ⑤ After disinfection, vacuum dry and seal and store at 4°C.

Embodiment 2

[0035] ① The warp and weft yarn raw material is polydioxanone monofilament with a diameter of 0.27mm, the width of part A (E) is 1.5cm, and the density of warp and weft is 20×20 / cm; the width of part B (F) is 1cm, and the density of warp and weft is 20×22 Roots / cm; fabric composition is ABABA;

[0036] ② Loosely insert the anti-blocking mold into the small tubular ring composed of double-layer pipe walls surrounding the longitudinal axis of the pipe wall;

[0037] ③Soak in 2% collagen solution for 3 minutes, take it out, and dry;

[0038] ④Apply 2% chitosan solution evenly and tightly on the inner layer to close the mesh and maintain air tightness;

[0039] ⑤ After disinfection, vacuum dry and seal and store at 4°C.

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Abstract

The invention relates to a degradable artificial trachea support frame and a manufacturing method thereof, which belong to the technical field of biological medicine. The support frame is characterized by being weaved into a circular pipe shape by polyp-dioxygen cyclohexanone monofilaments or polyglycolic acid monofilaments; the longitudinal axles of a tracheal wall transversely surround a pipe-shaped annulet formed by weaving the double-layered monofilaments at intervals; the monofilaments on the inner layer of the tracheal wall are bond uniformly; collagen is uniformly covered on the surfaces of the monofilaments; and chitosan is covered on the collagen in sequence. The manufacturing method comprises the following steps: weaving the circular pipe-shaped annular support frame; dipping the support frame into 2 percent of collage solution and drying; coating chitosan solution on the surface of the inner layer; and drying for standby. After the invention is executed, the stimulation of patches to human tissues is reduced and the anti-infectious capacity is strong, so as to be beneficial to reconstruct tracheas; a double-layer structure can accommodate the support frame for rehabilitating tracheal rings and achieve double rehabilitations in aspects of physiological anatomy and function of the defective tracheas; and the coating layer of the chitosan is arranged on the inner layer, so as to be beneficial to the creeping rehabilitation of tracheal endothelium.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a degradable artificial trachea stent and its manufacturing method. Background technique [0002] Due to tumor or trauma, partial resection of the trachea is often required. When the resection length of the trachea is greater than 6cm, which is equivalent to 10-12 cartilage rings, direct anastomosis cannot be performed because the tension of the anastomosis is too large. At this time, an artificial trachea is required. to fix. The use of artificial materials to replace trachea has been studied for more than half a century. Before 1990, the materials of artificial trachea were mostly silicone rubber tube and stainless steel. At present, the artificial tracheal prosthesis is divided into two categories according to whether the tube wall has holes or not. The non-porous artificial trachea is represented by a silicone tube (Neville tube). Its advantages are flexibility, elastic...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/06A61L31/10A61F2/04
Inventor 唐华徐志飞王文祖秦雄
Owner 唐华
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