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Antiseptic fixing liquid composition for cadaver sample and preparation method thereof

A technology of composition and fixative, applied in the preservation, application, animal husbandry and other directions of human or animal body, can solve the problems of inconvenient anatomical operation and exploration, poor penetration of fixative, hard and brittle tissue, etc. The effect of promotion and application, natural color, tissue flexibility

Inactive Publication Date: 2009-07-08
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, practice has proved that its most obvious disadvantage is that after fixing the gross specimen, the tissue becomes hard and brittle, and it is not easy to pull, which brings inconvenience to anatomical operation and exploration.
However, it is mainly used for the diagnosis and fixation of small organ tissue pathological sections in the hospital pathology department and surgical operating room, and the preparation of immunohistochemical sections. It is also only suitable for the fixation of small organ tissues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An embalming liquid composition specially used for animal or human corpse specimens, which consists of edetate disodium salt, glyoxal, potassium nitrate, sodium chloride, and sodium dehydroacetate.

[0025] Prepare 100 kilograms of this composition, take each component by following weight:

[0026] EDTA disodium salt: 0.3kg,

[0027] Glyoxal: 0.5kg,

[0028] Potassium nitrate: 0.2kg,

[0029] Sodium chloride: 0.5kg,

[0030] Sodium dehydroacetate: 0.5kg,

[0031] Add tap water to 100 kg.

[0032] The preparation process of the antiseptic fixative composition of this corpse specimen is:

[0033] First add the disodium salt of ethylenediaminetetraacetic acid and glyoxal of the above weight to 10 kg of tap water and stir evenly at normal temperature and pressure, then add potassium nitrate, sodium chloride, and sodium dehydroacetate, and add to 100 kg with tap water, Stirring for 1 hour, the finished product is obtained after standing still.

Embodiment 2

[0035] An antiseptic fixative composition for corpse specimens, which is composed of ethylene glycol diethyl ether diamine tetraacetic acid, succinaldehyde, potassium nitrate, sodium nitrate and sodium diacetate.

[0036] Prepare 100 kilograms of this composition, take each component by following weight:

[0037] Ethylene glycol diethyl ether diamine tetraacetic acid: 0.4kg,

[0038] Succinic dialdehyde: 0.4kg,

[0039] Potassium nitrate: 0.5kg,

[0040] Sodium nitrate: 0.6kg,

[0041] Sodium diacetate: 0.3kg,

[0042] Add tap water to 100 kg.

[0043] The preparation process of the antiseptic fixative composition of this corpse specimen is:

[0044] First, add about 10 kg of tap water to ethylene glycol diethyl ether diamine tetraacetic acid and succinic aldehyde in the above weight and stir evenly at normal temperature and pressure, then add sodium nitrate, sodium nitrate, and sodium diacetate, add to 100 kg with tap water, and stir After 2.0 hours, it is the finished ...

Embodiment 3

[0046] An antiseptic fixative composition for corpse specimens, which consists of disodium edetate, glutaraldehyde, potassium nitrate, sodium nitrate, potassium chloride and sodium dehydroacetate.

[0047] Prepare 100 kilograms of this composition, take each component by following weight:

[0048] EDTA disodium salt: 0.5kg,

[0049] Glutaraldehyde: 0.8kg,

[0050] Potassium nitrate: 0.4kg,

[0051] Sodium nitrate: 0.3kg,

[0052] Potassium chloride: 0.6kg,

[0053] Sodium dehydroacetate: 0.8kg,

[0054] Add tap water to 100 kg.

[0055] The preparation process of this dead body specimen embalming liquid fixing composition is:

[0056] Add about 10 kg of tap water to the disodium salt of ethylenediaminetetraacetic acid and glutaraldehyde in the above weight and stir evenly at room temperature and pressure, then add potassium nitrate, sodium nitrate, potassium chloride, and sodium dehydroacetate, and add tap water to 100 kg, stirred for 1.0 hour, and finished product afte...

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Abstract

The invention discloses an antiseptic stationary liquid composition for corpse specimen, mainly comprising a metal complexing agent, a protein corsslinking agent, an osmoregulation agent and a food-grade antiseptic / mildew inhibitor and water; the metal complexing agent is ethylenediamine tetracetic acid disodium salt or ethylene glycol diethyl ether ethylenediamine tetracetic acid, the protein corsslinking agent is glyoxal, malonaldehyde, succinaldehyde or glutaraldehyde, the osmoregulation agent is a mixture, according to any proportion, of more than two substances selected from potassium nitrate, sodium nitrate, potassium chloride and sodium chloride, the food-grade antiseptic / mildew inhibitor is sodium dehydroacetate, sodium diacetate or potassium sorbate. The inventive composition is dedicated to antisepsis and fixing perfusion for animal or human corpses and has the advantages of strong antiseptic performance, good fixing performance and excellent safety without formaldehyde and toxicity. The invention also provides a method for preparing the antiseptic stationary liquid composition for corpse specimen.

Description

technical field [0001] The invention relates to the fixed perfusion, anti-corrosion and mildew-proof of corpse specimens in medical teaching and scientific research. Background technique [0002] After the death of a person or animal, if the body is not embalmed and fixed, the tissue will autolyze, rot, and gradually disintegrate. Specimen preservation is generally carried out in two steps: first, the corpse is fixed with a fixative solution, and then the corpse treated with anticorrosion and fixation is preserved with a preservation solution. If the corpse is not fixed well, it will be difficult to keep moisture, keep the shape, and preserve the body during the preservation process. [0003] Since Blum used formaldehyde-containing aqueous solution (formalin) for embalming and fixing cadaver specimens in 1893, it is still the main component of most embalming fixatives. Eerden's survey of 420 units shows that formaldehyde solution accounts for 97% of the main components of ...

Claims

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Application Information

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IPC IPC(8): A01N1/00
Inventor 曹建明刘佳明周铁丽杨新东楼新法吴新华周茹
Owner WENZHOU MEDICAL UNIV
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