Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Artocarpus heterophyllus extract for treating cerebrovascular disease and preparation method thereof

A technique for cardiovascular and cerebrovascular diseases and extracts, applied in the field of pharmaceutical preparations, can solve problems such as cardiovascular diseases that have not yet been discovered, and achieve the effects of inhibiting platelet aggregation, reducing blood viscosity, and protecting cardiomyocytes.

Inactive Publication Date: 2012-10-03
ZHEJIANG UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the available literature, no reports on the treatment of cardiovascular diseases with mbolo bioactive compounds have been found.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Artocarpus heterophyllus extract for treating cerebrovascular disease and preparation method thereof
  • Artocarpus heterophyllus extract for treating cerebrovascular disease and preparation method thereof
  • Artocarpus heterophyllus extract for treating cerebrovascular disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0016] The preparation method of the present invention comprises the following steps:

[0017] 1. Ethanol extracts the leaves of Muboro to obtain the total ethanol extract of Muboro.

[0018] Get the leaves of Muboluo and dry them in the shade; then use 75% by volume ethanol solution (the remaining 25% is water) to heat and reflux extract 3 to 5 times, each time the amount of ethanol solution is 10 to 15 liters per kilogram of leaves; combined extraction liquid, and evaporated to dryness under reduced pressure to obtain the total ethanol extract of Muporo, with a yield of 10-15%. The extract is yellow-brown powder with complex components.

[0019] 2. Roughly separate the total ethanol extract of Muboro to obtain petroleum ether extraction parts and ethyl acetate extraction parts.

[0020] Such as figure 2 As shown, take the total ethanol extract of Muporo and suspend it in water (10-12 liters of water per 100 grams of extract), and then use petroleum ether and ethyl acetat...

Embodiment

[0031] Take 3 kilograms of dried leaves of Muboluo, heat and reflux with 75% ethanol aqueous solution to extract 3 times, and the solvent consumption is 30 liters each time. The extracts were combined and evaporated to dryness to obtain 335 g of the total ethanol extract.

[0032] The ethanol extract was added to 33 liters of water to suspend, and then extracted with petroleum ether, ethyl acetate, and n-butanol respectively to obtain 62 g of petroleum ether extraction fractions, 131 g of ethyl acetate extraction fractions and 38 g of n-butanol extraction fractions.

[0033] The extraction process of the total flavonoids is to use the 200-300 mesh silica gel column to perform chromatography on the ethyl acetate extraction part (131 grams) of Muboluo. A mixed solution of petroleum ether and ethyl acetate was used for elution, and petroleum ether:ethyl acetate=3:1 was used for elution, and the sample was about 20 grams, which was the effective fraction of total flavonoids.

[0...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a wood pineapple extract for treating cardiovascular and cerebrovascular diseases and preparation method thereof. In which, the wood pineapple extract is beta-sitosterol and flavones extracted from wood pineapple leaves by the process of: extracting the wood pineapple leaves by ethanol to obtain wood pineapple ethanol total extract; separating the wood pineapple ethanol total extract roughly to obtain petroleum ether extracting extraction position and ethyl acetate extraction position; and purifying and separating the petroleum ether extracting extraction position and ethyl acetate extraction position to obtain the wood pineapple extract for treating cardiovascular and cerebrovascular diseases: beta-sitosterol and flavones. The obtained extract has the functions ofantithrombotic, platelet aggregation inhibition, blood viscosity reduction and cardiac muscle cell protection.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a Mupolo extract for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Moraceae, the genus of Moraceae, commonly known as jackfruit, grows in tropical regions, including Indonesia, Thailand, Vietnam and Cambodia, and is often used as a source of carbohydrates. Muporo contains essential amino acids, such as histidine, isoleucine, betaine, methionine, tryptophan and valine, which have special effects on health. [0003] Although not scientifically proven, Indonesia has traditionally used Muporo leaves to treat diseases such as hepatitis, heart disease, nephritis, dental disease and itching. Taiwan has also been reported to use the roots and stems of wood polo to treat liver disease, cirrhosis, and high blood pressure. Most of the research on mbolo shows that this plant is very beneficial to health. Kan ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00C07D311/30A61K36/60A61P9/00A61K127/00
Inventor 郑筱祥严伟民邓同乐孙永红潘远江何山乌玛尔·安卡拉·杰尼来昂那多·布偌托·苏根·卡多罗陈嘉瓦蒂·莫扎芙
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com